Siddhartha Roy , Ph.D.

Senior Principal Scientist
Structural Biology & Bioinformatics
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Research Focus

We seek to understand the role of certain macromolecules in the regulation of transcription and chromatin dynamics which crucially impact many fundamental biological processes including development and disease. The ongoing research of the laboratory is focused on dissecting the molecular basis of chromatin organization by means of mediating histone modifications by writer enzymes and histone assembly by histone chaperones - with a combined approach of structural biology, biochemistry, and biophysical approaches.

Research Interest

Our laboratory focuses on advancing our understanding of chromatin biology and epigenetic mechanisms, with particular emphasis on their roles in human disease. Our key research interests include:

  1. Elucidating the structural and functional aspects of histone chaperones in DNA damage repair pathways and investigating their implications in rare genetic disorders.
  2. Small molecule inhibitors that target epigenetic regulatory enzymes implicated in human metabolic disease pathways.
  3. Characterizing the structural features and functional mechanisms of histone ubiquitin ligases across various disease contexts.
  4. Integrating biochemical, cell biology, and structural biology approaches to target human epigenetic reader domain-containing proteins in cancer disease.

Credentials

  • Post-doctoral Research Fellow (2010-2012) MD Anderson Cancer Center, Houston, USA
  • Post-doctoral Research Fellow (2008-2010) University of Colorado Denver, Aurora, USA
  • Ph.D (2007) Indian Institute of Science, Bangalore, India 

Patents & Publications

Selected Publications:

  1. Srivastava DK, Nandi S, Karmakar A, Das C, Roy S*. The chromatin reader ZMYND8 recruits the NuRD component GATAD2A through its MYND domain to regulate MAPT213 long noncoding RNA transcription. J Biol Chem. 2026 Apr 16;:111463.
  2. Dhang S, Mondal A, Das C, Roy S*. Metformin inhibits the histone methyltransferase CARM1 and attenuates H3 histone methylation during gluconeogenesis. J Biol Chem. 2025 Mar;301(3):108271 (Cover Page).
  3. Dalui S, Dasgupta A, Adhikari S, Das C, Roy S*. Human testis-specific Y-encoded protein-like protein 5 is a histone H3/H4-specific chaperone that facilitates histone deposition in vitro. J Biol Chem. 2022 Aug;298(8):102200. 
  4. Dasgupta A, Mondal P, Dalui S, Das C, Roy S*. Molecular characterization of substrate-induced ubiquitin transfer by UBR7-PHD finger, a newly identified histone H2BK120 ubiquitin ligase. FEBS J. 2022 Apr;289(7):1842-1857. (Editor’s Choice)
  5. Srivastava DK, Gunjan S, Das C, Seshadri V, Roy S*. Structural insights into histone chaperone Asf1 and its characterization from Plasmodium falciparum. Biochem J. 2021 Mar 12;478(5):1117-1136. (Cover Page).
  6. Adhikary S, Chakravarti D, Terranova C, Sengupta I, Maitituoheti M, Dasgupta A, Srivastava DK, Ma J, Raman AT, Tarco E, Sahin AA, Bassett R, Yang F, Tapia C, Roy S*, Rai K*, Das C*. Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor. Nat Commun. 2019 Mar 28;10(1):1398. (equal corresponding author)
  7. Adhikary S, Sanyal S, Basu M, Sengupta I, Sen S, Srivastava DK, Roy S*, Das C*. Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8. J Biol Chem. 2016 Feb 5;291(6):2664-81. (equal corresponding author)

 

For a complete list of publications:

https://www.ncbi.nlm.nih.gov/myncbi/siddhartha.roy.7/bibliography/public/

 

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