Md. Jahangir Alam, PhD

Scientist
Cell Biology & Physiology
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Research Interest

Cardio-metabolic diseases (CMDs) such as cardiovascular disease, stroke and diabetes have been a major concern worldwide due to their increasing prevalence in Low middle-income countries, especially in India. CMDs arise primarily due to various factors such as sedentary lifestyle, intake of high-energy food, obesity, smoking and air pollution. Due to its steady increase globally and particularly in India, the epidemiology and management of CMDs have received detailed attention and roadmaps to address specific diseases are essential.

In view of this scenario, my research interest is to identify the key early molecular events contributing to the development of chronic diseases such as cardiovascular (e.g., coronary artery disease) and metabolic diseases (e.g., non-alcoholic fatty liver disease). More specifically, my research goal is to use interdisciplinary approaches for addressing crucial questions such as the impact of metabolic alteration, lipid metabolism, oxidative stress, mitochondrial dynamics and inflammation on cardiovascular disorders. To solve such biological questions, I use high throughput technologies, e.g., proteomics, next-generation sequencing and metabolomics, which will help to understand the mechanisms of disease onset and the development of new therapeutic strategies.

Currently, we are working on the following aspects in the domain of Cardio-metabolic Diseases:

  • Finding the link between metabolic alteration and CVDs.
  • Understanding the roles of extracellular vesicles in CVDs.
  • Identification and validation of early protein biomarkers for atherosclerotic CVDs.

Credentials

ICMR-RA (2019-2022), THSTI, Faridabad, Haryana, INDIA and National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, INDIA

Research Associate, DBT (2017-2019), Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, INDIA

PhD in Life Sciences (2016), School of Life Sciences, Jawaharlal Nehru University, New Delhi, INDIA.

M.Phil./PhD program in Life Sciences (2009-2010), School of Life Sciences, Jawaharlal Nehru University, New Delhi, INDIA.

M.Sc. Biotechnology (2009), Jamia Hamdard, New Delhi, INDIA.

Honours & Awards

  • ICMR-Research Associate fellowship from 2019 to 2022.
  • First prize for best e-poster presentation at the International Society for Heart Research 2019 (ISHR 2019), Jaipur-India.
  • Department of Biotechnology (DBT)-JRF, 2010.
  • Jawaharlal Nehru University Fellowship from 2009 to 2010.
  • Qualified joint CSIR-UGC (NET)-2009

Patents & Publications

  1. Alam, M.J., Kamboj, P., Sarkar, S., Gupta, S.K., Kasarla, S.S., Bajpai, S., Kumari, D., Bisht, N., Barge, S.R., Kashyap, B., Deka, B., Bharadwaj, S., Rahman, S., Dutta, P.P., Borah, J.C., Talukdar, N.C., Kumar, Y., Banerjee, SK. 2023. Untargeted metabolomics and phenotype data indicate the therapeutic and prophylactic potential of Lysimachia candida Lindl. towards high-fat high-fructose-induced metabolic syndrome in rats. Mol Omics. doi:10.1039/d3mo00104k
  2. Alam, M.J., Uppulapu, S.K., Tiwari, V., Varghese, B., Mohammed, S.A., Adela, R., Arava, S.K., Banerjee, S.K. (2022) Pregestational Diabetes Alters Cardiac Structure and Function of Neonatal Rats Through Developmental Plasticity. Front Cardiovasc Med (accepted). IF: 5.84
  3. Paramesha, B., Mohammed, S.A., Alam, M.J., Meghwani, H., Maulik, S.K., Arava, S.K., Banerjee, S.K. (2022) Empagliflozin prohibits high fructose diet induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress. Life Sciences, 307, 120862. IF: 6.78
  4. Johny, E., Jala, A., Nath, B., Alam, M.J., Kuladhipati, I., Das, R., Borkar, R.M., Adela, R. (2022) Vitamin D supplementation modulates platelet mediated inflammation in subjects with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Front Immunol 26, 13:869591. IF: 7.56
  5. Paramesha, B.,Alam, M.J., Kumar R., Pal S., Chattopadyay, N., and Banerjee, S.K. (2022) Sirt3 ameliorates mitochondrial dysfunction and oxidative stress through regulating mitochondrial biogenesis and dynamics in cardiomyoblast. Cell signal 94, 110309. IF:4.85
  6. Malladi, N., Johny, E., Uppulapu, S.K., Tiwari, V., Alam, M.J., Adela, R., and Banerjee, S.K. (2021). Understanding the Activation of Platelets in Diabetes and Its Modulation by Allyl Methyl Sulfide, an Active Metabolite of Garlic. Journal of Diabetes Research, e6404438. IF: 4.06
  7. Johny, E., Bhaskar, P., Alam, M.J., Kuladhipati, I., Das, R., and Adela, R. (2021). Platelet Mediated Inflammation in Coronary Artery Disease with Type 2 Diabetes Patients. J Inflamm Res 14, 5131–5147. IF: 4.63
  8. Kamboj, P., Sarkar, S., Gupta, S.K., Bisht, N., Kumari, D., Alam, Md.J., Barge, S., Kashyap, B., Deka, B., Bharadwaj, S., et al. (2021). Methanolic Extract of Lysimachia Candida Lindl. Prevents High-Fat High-Fructose-Induced Fatty Liver in Rats: Understanding the Molecular Mechanism Through Untargeted Metabolomics Study. Front. Pharmacol. 12, 653872. IF: 5.81
  9. Sarkar, S., Bhattacharya, S., Alam, MJ., Yadav, R., Banerjee, SK. (2020). Hypoxia aggravates non-alcoholic fatty liver disease in presence of high fat choline-deficient diet: A pilot study. Life Sci. 260 (2020) 118404, 1-7, IF: 6.78
  10. Alam, M.J., Gupta, R., Mahapatra, N.R., and Goswami, S.K. (2020). Catestatin reverses the hypertrophic effects of norepinephrine in H9c2 cardiac myoblasts by modulating the adrenergic signaling. Mol. Cell. Biochem. 464, 205–219, IF: 3.84
  11. Kumar, S., Alam, M.J., Prabhakar, P., Maulik S.K., and Goswami, S.K. (2017) Terminalia arjuna (Roxb.) Reverses the Molecular Signature of Fibrosis Induced by Isoproterenol in Rat Heart. Am J Phytomed Clin Ther. Vol. 5 No. 3:22, 1-10
  12. Kumar, S., Alam, M.J., Prabhakar, P., Ahmad, S., Maulik, S.K., Sharma M., and Goswami, S.K. (2017). Proteomic Analysis of the Protective Effects of Aqueous Bark Extract of Terminalia arjuna (Roxb.) on Isoproterenol-induced Cardiac Hypertrophy in Rats. J Ethnopharmacol. 198, 98-108, IF: 5.19
  13. Thakur, A.*, Alam, M.J*., Ajayakumar, M.R., Ghaskadbi, S., Sharma, M., and Goswami, S.K. (2015). Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation. Redox Biol. 5, 243–252 (*Equal first author)., IF: 10.78

 

BOOK CHAPTERS/REVIEWS

  1. Shreya, S., Alam, M.J., Anupriya., Jaiswal, S., Rani, V., Jain, B.P. (2023). Lipotoxicity, ER stress, and cardiovascular Disease: Current understanding and future directions. Cardiovasc Hematol Agents Med Chem.(accepted)
  2. Navya, M., Alam, M.J., Maulik, S.K., Banerjee, S.K. (2023). The Role of Platelets in Non-Alcoholic Fatty Liver Disease: From Pathophysiology to Therapeutics. Prostaglandins & Other Lipid Mediat 106766. doi:10.1016/j.prostaglandins.2023.106766
  3. Purohit, A., Kandiyal, B., Alam, M.J., Shalimar, Das, B., Banerjee, S.K. (2022) Chapter 8 Gut microbiome and Non-alcoholic fatty liver disease. In Progress in Molecular Biology and Translational Science (Series: Human Microbiome in Health and Disease), K. Verbeke, ed. (Academic Press) (accepted). IF: 3.62
  4. Alam, M.J., Puppala, V., Uppulapu, S.K. and Banerjee, S.K. (2022) Chapter 15 Human microbiome and cardiovascular diseases. In Progress in Molecular Biology and Translational Science (Series: Human Microbiome in Health and Disease), K. Verbeke, ed. (Academic Press) (accepted). IF: 3.62
  5. Alam, M.J., Uppulapu, S.K., Maulik, S.K., and Banerjee, S.K. (2022). Chapter 28 - Ethnopharmacological and therapeutic potential of Terminalia arjuna and Camellia sinensis against cardiovascular diseases: Evidence and experimental studies. In Evidence-Based Validation of Herbal Medicine (Second Edition), P.K. Mukherjee, ed. (Elsevier), pp. 651–669.
  6. Uppulapu, S.K., Alam, M.J., Banerjee, S.K. (2021). Indazole and its derivatives in cardiovascular diseases: Overview, current scenario and future perspectives. Curr Top Med Chem. IF: 3.57
  7. Alam, Md.J., and Banerjee, S.K. (2020). Chapter 2 Obesity-Induced Cardiovascular Complications and Therapeutic Intervention. In Biochemistry of Cardiovascular Dysfunction in Obesity, P.S. Tappia, S.K. Bhullar, and N.S. Dhalla, eds. (Cham: Springer International Publishing), pp. 15–53.
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