Indrajit Das , Ph.D.

Principal Scientist
Organic & Medicinal Chemistry

Research Interest

  1. Electrochemistry: Electrochemical C-C and C-X bond formation
  2. Photochemistry: Visible-light-mediated reactions
  3. Visible-Light-Mediated Synthesis of C-C and C-Heteroatom Bond
  4. Development of New Reagents, their Unique Synthetic Transformations, and Mechanistic Aspects
  5. α-Keto Thioesters as Building Block for Accessing Diverse Heterocycles
  6. Transition-Metal-Mediated Organic Transformations


  • Postdoctoral Fellow (January 2007 – December 2008): DPM-University Joseph Fourier, France
  • Ph.D. (January 2002 – December 2006): IIT-Kharagpur, India
  • M.Sc. (2001): Rajabazar Science College, Calcutta University, Kolkata
  • B.Sc. (1999): Ramakrishna Mission Residential College – Narendrapur, Calcutta University, Kolkata

Patents & Publications


  1. An Improved Process for Synthesis of Mandipropamid, Indrajit Das, Jayanta Saha, Sumit Biswas, Subhadeep Ghosh, 2024, Indian Patent Application No. 202411033733 dated on 26/04/2024.
  2. Preparation of PNA-​6-​aminoglucosamine conjugates as antiviral agents By Virendra N Pandey, Jean-Luc Decout, Indrajit Das, Jérôme Désiré; U.S. Pat. Appl. Publ. (2014), US 20140371137 A1 20141218. 
  3. 6-amino-6-deoxyglucosamine derivatives and their use as antibacterial agents By Jean-Luc Decout, Isabelle Baussanne, Jerome Desire, Indrajit Das, and Marie-Paule Mingeot-Leclercq PCT Int. Appl. 2012, WO 2012062996 A1 20120518.
  4. 6-amino-6-deoxyglucosamine derivatives and their use as antibacterial agents By Jean-Luc Decout, Indrajit Das, Jerome Desire, Isabelle Baussanne, and Marie-Paule Mingeot-Leclercq Fr. Demande, 2012, FR 2967068 A1 20120511.



  1. Abhijit Bankura, Subhadeep Ghosh, Sumit Biswas, and Indrajit Das*, Convergent Paired Electrolysis for [3+2] Cycloaddition of Azidotrimethylsilane with N-Heterocycles, 2024, ChemSusChem, e202400381, "Accepted Article", 
  2. Jayanta Saha, Soumadip Banerjee, Sidhartha Malo, Abhijit Kumar Das,* and Indrajit Das* A Torquoselective Thermal 6π-Electrocyclization Approach to 1,4-Cyclohexadienes via Solvent-Aided Proton Transfer: Experimental and Theoretical Studies, 2024, Chem. Eur. J."Accepted Article"e202304009

  1. Sumit Biswas, Subhadeep Ghosh, and Indrajit Das*, Supporting Electrolyte-Free Electrochemical Oxidative C‒H Sulfonylation and Thiocyanation of Fused Pyrimidin-4-ones in an All-Green Electrolytic System, 2023,Chem. Eur. J., "Accepted Article", DOI:
  2. Rajib Maity,* Abhijit Bankura, and Indrajit Das*, Electrochemical cascade sequences for the remote C7‒H bond thiocyanation of quinoxalin-2(1H)-ones with ammonium,2023, Green Chemistry, 25, 7774-7781,
  3. Jayanta Saha, Soumadip Banerjee, Sidhartha Malo, Abhijit Kumar Das,* Indrajit Das*; Thermally-Activated Geometrical Regioselective E → Z Isomerization-Enabled Cascade Sequences of Conjugated Dienals: Experimental and DFT Studies, 2023, Chem. Eur. J. "Accepted Article"
  4. Rajib Maity, Subhadeep Ghosh, Indrajit Das*; Integrating Regioselective E→Z Isomerization of Trienones with Cascade Sequences under Photosensitizer-Free Direct Irradiation at 390 nm, 2023, Chem. Eur. J. , 29, e202300421,
  5. Indrajit Das, Jayanta Saha, Sidhartha Malo; An Improved Process for Synthesis of Insecticide Pymetrozine, 2023, Patent, Indian Patent Application No. 202311014139 dated on 02/03/2023.    
  6. Sandip Naskar,+ Rajib Moi,+ Indrajit Das,* Kumar Biradha* S. Naskar and Dr. I. Das; Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India, R. Moi and Prof. K. Biradha; Department of Chemistry, Indian Institute of Technology (IIT) Kharagpur, India [+], These authors contributed equally to this work, Halogen⋅⋅⋅Halogen and Halogen⋅⋅⋅π Interactions Enabled Reversible Photo-oligomerization of Conjugated Dienones: Visible Light Triggered Single-Crystal-to-Single-Crystal Transformation, 2022, Angew. Chem. Int. Ed. "Accepted article"
  7. Sandip Naskar, Kanchan Mal, Rajib Maity, and Indrajit Das* Recent Advances in the Synthesis and Applications of α-Ketothioesters, 202,0 Adv. Synth. Catal. "Accepted article" DOI:10.1002/adsc.202001191
  8. Abhijit Bankura, Jayanta Saha, Rajib Maity, and Indrajit Das*, Non‐Bonding 1,4‐Sulphur‒Oxygen Interaction Governs the Reactivity of α‐Ketothioesters in Triphenylphosphine‐Catalyzed Cyclization with Acetylenedicarboxylates, 2021, Adv. Synth. Catal. 363 1014-1021  DOI:10.1002/adsc.202001376
  9. Abhijit Bankura, Sandip Naskar, Sabyasachi Roy Chowdhury, Rajib Maity, Sabyashachi Mishra* and Indrajit Das*, C3-Thioester/-Ester Substituted Linear Dienones: A Pluripotent Molecular Platform for Diversification via Cascade Pericyclic Reactions, 2020, Adv. Synth. Catal. 362, 3604-3612 DOI:10.1002/adsc.202000362
  10. Jayanta Saha and Indrajit Das* Solvent Dependent Divergent Reactivity of Electron-Rich Dienones with and without Visible Light: Access to Cyclopropanated Furans and Butenolides  , 2020, Adv. Synth. Catal. 362, 609-617, DOI:10.1002/adsc.201901273
  11. Rajib Maity, Bhanuranjan Das, and Indrajit Das* Transition-Metal-Free Reduction of α-Keto Thioesters with Hydrosilanes at Room Temperature: Divergent Synthesis through Reagent-Controlled Chemoselectivities , 2019, 361, 2347-2353, Adv. Synth. Catal.  Just accepted mansucript. DOI 10.1002/adsc.201900222
  12. Sandip Naskar, Sabyasachi Roy Chowdhury, Somrita Mondal, Dilip K. Maiti, Sabyashachi Mishra,*and Indrajit Das*; Visible-Light-Activated Divergent Reactivity of Dienones: Dimerization in Neat Conditions and Regioselective E to Z Isomerization in the Solvent , 2019 , 21, 1578-1582,  Org. Lett. , just accepted manuscript DOI: 10.1021/acs.orglett.9b00083
  13. Rajib Maity, Sandip Naskar, and Indrajit Das* ; Copper(II)-Catalyzed Reactions of α-Keto Thioesters with Azides via C-C and C-S Bond Cleavages: Synthesis of N-Acylureas and Amides , 2018 , J. Org. Chem. , 83 , 2114-2124 , DOI: 10.1021/acs.joc.7b03054
  14. Rajib Maity, Sandip Naskar, Kanchan Mal, Sandipa Biswas, and Indrajit Das* ; Access to 2-Thioxooxazolidin-4-ones and Oxazolidine-2,4-diones from α-Keto Thioesters through Thiolate Transfer , 2017 , Adv. Synth. Catal. , 359 , 4405–4410 ,
  15. Kanchan Mal and Indrajit Das* ; α-Keto Thioesters as Building Blocks for Accessing γ-Hydroxybutenolides and Oxazoles , 2017 , Adv. Synth. Catal. , 359 , 2692-2698 ,
  16. Sandip Naskar and Indrajit Das* ; Elusive Thiyl Radical Migration in a Visible Light Induced Chemoselective Rearrangement of γ-Keto Acrylate Thioesters: Synthesis of Substituted Butenolides By Sandip Naskar , 2017 , Adv. Synth. Catal. , 359 , 875-885 ,
  17. Kanchan Mal, Sandip Naskar, Shovan Kumar Sen, Ramalingam Natarajan, and Indrajit Das*; Tandem Chemoselective 1,2-/1,4-Migration of the Thio Group in Ketothioesters: An Efficient Approach to Substituted Butenolides , 2016 , Adv. Synth. Catal. , 358 , 3212-3230 ,
  18. Louis Zimmermann, Indrajit Das, Jérôme Désiré, Guillaume Sautrey, Vinicius Barros R. S., Micheline El Khoury, Marie-Paule Mingeot-Leclercq, and Jean-Luc Decout* ; New Broad-spectrum Antibacterial Amphiphilic Aminoglycosides Active Against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues , 2016 , J. Med. Chem. , 59 , 9350-9369 , DOI: 10.1021/acs.jmedchem.6b00818
  19. Kanchan Mal and Indrajit Das*; Base Induced Chiral Substituted Furans and Imidazoles from Carbohydrate-Derived 2-Haloenones , 2016 , J. Org. Chem. , 81 , 932-945 , DOI: 10.1021/acs.joc.5b02500
  20. Kanchan Mal, Amanpreet Kaur, and Indrajit Das*; Chirally Substituted 3-Formylfurans from Carbohydrates: An Expedient Route via NBS-Mediated Electrophilic Cyclization , 2015 , Asian J. Org. Chem. , 4 , 1132-1143 ,
  21. Kanchan Mal, Amanpreet Kaur, Fazle Haque, and Indrajit Das*; PPh3.HBr-DMSO: A Reagent System for Diverse Chemoselective Transformations , 2015 , J. Org. Chem. , 80 , 6400–6410 , DOI: 10.1021/acs.joc.5b00846
  22. Kanchan Mal, Supriya Das, Nakul C. Maiti, Ramalingam Natarajan, and Indrajit Das* ; ZnI2-Catalyzed Diastereoselective [4+2] Cycloadditions of β,γ-unsaturated α-ketothioesters with Olefins , 2015 , J. Org. Chem. , 80 , 2972–2988 , DOI: 10.1021/jo5024766
  23. Kanchan Mal, Abhinandan Sharma, and Indrajit Das* ; Gold(III) Chloride Catalyzed Synthesis of Chiral Substituted 3-Formyl Furans from Carbohydrates: Application to the Synthesis of 1,5-Dicarbonyl Derivative and Furo[3,2-c]pyridine , 2014 , Chem. Eur. J. , 20 , 11932-11945 ,
  24. Kanchan Mal, Abhinandan Sharma, Prakas R. Maulik, and Indrajit Das*; PPh3.HBr-DMSO mediated expedient synthesis of γ-substituted β,γ-unsaturated α-ketomethylthioesters and α-bromo enals: Application to the synthesis of 2-methylsulfanyl-3(2H)-furanones , 2014 , Chem. Eur. J. , 20 , 662-667 ,
  25. Indrajit Das, Jérôme Désiré, Dinesh Kumar Manvar, Isabelle baussanne, Virendra N Pandey, and Jean-Luc Decout* ; A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-mediated Transactivation of HIV-1 Transcription , 2012 , J. Med. Chem. , 55 , 6021–6032 , DOI: 10.1021/jm300253q
  26. Indrajit Das, Cheravakkattu G. Suresh, Jean-Luc Décout, and Tanmaya Pathak*; Unusual addition of amines to C-2 of vinyl sulfone-modified-β-d-pent-2-enofuranosyl carbohydrates: synthesis of a new class of β-anomeric 2-amino-2,3-dideoxy-d-threo-pentofuranosides , 2008 , Carbohydr. Res. , 343 , 1287-1296 ,
  27. Indrajit Das, Tarun K. Pal, and Tanmaya Pathak*; Diastereoselective Michael Initiated Ring Closure on Vinyl Sulfone-Modified Carbohydrates:  A Stereospecific and General Route to α-Substituted Cyclopropanes , 2007 , J. Org. Chem. , 72 , 9181–9189 , DOI: 10.1021/jo701378d
  28. Indrajit Das, Tarun K. Pal, Cheravakkattu G. Suresh, and Tanmaya Pathak*; Diastereoselective C−C Bond Formation at C-5 of Vinyl Sulfone-Modified Hex-5-enofuranosyl Carbohydrates:  Diversity-Oriented Synthesis of Branched-Chain Sugars and Beyond , 2007 , J. Org. Chem. , 72 , 5523–5533 , DOI: 10.1021/jo062373+
  29. Indrajit Das, and Tanmaya Pathak*; Desulfonylation with Mg−MeOH−NiBr2:  An Expedient Reagent System for the Synthesis of 2-Amino-2,3-dideoxy Furanosides , 2006 , Org. Lett. , 8 , 1303–1306 , DOI: 10.1021/ol053082a
  30. Indrajit Das, Tanmaya Pathak,* Cheravakkattu G. Suresh; A Diastereoselective and General Route to 5-Amino-5-deoxysugars:  Influence of C-3 Substitution on the Addition of Amines to C-5 of Vinyl Sulfone-Modified Hex-5-enofuranosyl Carbohydrates , 2005 , J. Org. Chem. , 70 , 8047–8054 , DOI: 10.1021/jo051143c