Chinmay Chowdhury , Ph.D., FAScT

Chief Scientist
Organic & Medicinal Chemistry
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Research Interest

  1. Palladium-catalyzed synthesis of novel oxygen- and nitrogen-heterocycles of biological interests.
  2. Isolations & identifications of bioactivity guided extracts, fractions and unique bioactive molecules from Indian medicinal plants.
  3. Up scaling & process development for value added natural products.
  4. Preparation of analogue library and nano-formulations of lead phytomolecules.
  5. Development potent anti-cancer lead compounds.

 

  • Our paper in the front outside cover page of  “Chemical Communications”(click here)
  • Our paper in the cover page of  “Chemistry A European Journal” ((click here)
  • Our paper in the cover page of the journal "Organic & Biomolecular Chemistry" (click here)
  • Dr. Chinmay Chowdhury has been awarded with "Bharat Vikas Award" (Click here)

Credentials

  • Chief Scientist (2021-Till date)
  • Professor, Academy of Scientific and Innovative Research (AcSIR).
  • Senior Principal Scientist (2015-2021) & Deputy Head of the Department, Organic and Medicinal Chemistry Department, CSIR-IICB, Kolkata.
  • Principal Scientist, CSIR-IICB, Kolkata (2009-2015).
  • Scientist E1, CSIR- IICB, Kolkata (2006-2009).
  • Scientist E1, CIMAP, Lucknow (2004-2006).
  • Post-Doctoral Research, University Of California, San Diego, USA  (2000-2002).
  • Post-Doctoral Research , University Of Kentucky, Lexington, USA (1999-2000).
  • Ph.D. (Organic Chemistry) Indian Association for the Cultivation of Science, Kolkata (1991-1998).
  • M.Sc. (Chemistry), Indian Institute of Technology (IIT), Kharagpur (1989-1991).
  • B.Sc. (Hons) in Chemistry,  Narendrapur Ramkrishna Mission Residential College (1986-1989).

Honours & Awards

  • Fellow of West Bengal Academy of Science and Technology (WAST), 2019.
  • Received "Bharat Vikas Award", 2019.
  • Life member of Indian Chemical Society.
  • Serving (Year 2024-2026) as sectional Committee (Chemical Sciences) member  of West Bengal Academy of Science & Technology (WAST).

Grants & Supports

SERB, Department of Science & Technology, New Delhi

  1. Indian Council of Medical Research (ICMR), New Delhi.
  2. Department of Biotechnology, Govt. of West Bengal.

Patents & Publications

PUBLICATIONS   

  1. Sarat Chatterjee, Rousunara Khatun, Mahammad Ali, and Chinmay Chowdhury*; A solvent controlled regioselective synthesis of 2- and 4-substituted α-carbolines under palladium catalysis, Chem. Commun., 2024, 60, 7427–7430 (the article has been selected to appear as a cover art at the front outside cover of the journal) click here


  2. Debasmita Dutta, Ashique Al Hoque,  Brahamacharry Paul,  Anirban Sengupta, Jun Hyoung Park, Chinmay Chowdhury, Mohiuddin Quadir, Soumyabrata Banerjee, Arghadip Choudhury, Soumik Laha, Nayim Sepay, Priyanka Boro, Benny A. Kaipparettu and   Biswajit Mukherjee,  "EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment"  J. Biomedical Science, 2024, 31: 81. ( https://doi.org/10.1186/s12929-024-01069-8)
  3. Sukanya De and Chinmay Chowdhury*; Iron(III)-Catalyzed Carboannulations of Homopro- pargylic Alcohols: A One-Pot General Synthesis of 4 (2,2-Diarylvinyl)quinolines and 4 (2,2-Diarylvinyl) 2H chromenes, Journal of Organic Chemistry, 2023, 88, 7539-7550.
  4. Sukanya De and Chinmay Chowdhury*; Substrate Controlled Product Divergence in Iron(III)-Catalyzed Reactions of Propargylic Alcohols: Easy Access to Spiro-indenyl 1,4-Benzoxazines and 2-(2,2-Diarylvinyl)quinoxalines, Chemistry-A European journal,  2023, 29, e202203993 (published  as hot paper and this work was highlighted as  cover art of the journal, see. https://doi.org/10.1002/chem.202300439 )
  5. Shila Elizabeth Besra, Moumita Ray, Subhodeep Roy and Chinmay Chowdhury, Cytotoxic Activity of Bark of Oroxylon indicum Benth against U937and K562, Int. J. Pharm. Sci. Rev. Res. 2022, 75(1), 73-78.
  6. Debasmita Mondal, Subhendu Pramanik and Chinmay Chowdhury*; Palladium(0)-Catalyzed Heteroannulations of Allenamides: General Synthesis of δ-Carbolines  and Benzofuro[3,2-b]pyridines, Organic Letters, 2022, 24, 8698-8702.
  7. Subhendu Pramanik, Sarat Chatterjee, Rumjhum Banerjee and Chinmay Chowdhury*; “Palladium-Catalyzed Benzannulations of 1-(Indol-2-yl)but-3-yn-1-ols: Easy Access to Functionalized Carbazoles”; Organic  Letters, 2022, 24,  1895–1900.
  8. Debasmita Mondal, Gargi Pal and Chinmay Chowdhury*; Palladium(0)-catalysed regioselective cyclisation of 2-amino(tosyl)  benzamides/sulphonamides: Stereoselective  synthesis of 3-ylidene-[1,4]benzodiazepin-5-ones/benzo[f][1,2,5]thiadiazepine-1,1-dioxides, Chem. Commun. 2021, 57, 5462-5465.
  9. Amrita Mondal, Chinmay Chowdhury*; “Palladium-Catalyzed Synthesis of 1-Vinyltetrahydro-β-carbolines and Aza-spiroindolenines: Access to the Syntheses of 1-Vinyl β-carbolines and Eudistomins Y1 and Y2”, Journal of Organic Chemistry, 2021, 86, 3810-3825. 
  10. Sukanya De, Moumita Jash and Chinmay Chowdhury*; “Palladium(II) catalysed cascade strategy for the synthesis of dibenzo[5,6:7,8]cycloocta[1,2-b]indole-10-ols/-10(15H)-ones: Easy access to 1,3,5,7-cyclooctatetraenes (COTs)”, Chem. Commun. 2020, 56, 15659-15662. 
  11. Moumita Jash, Sukanya De, Subhendu Pramanik, Chinmay Chowdhury*; “Palladium(II)-Catalyzed Cascade Reactions of Ene-ynes Tethered to Cyano/Aldehyde: Access to Naphtho[1,2-b]furans and Benzo[g]indoles”, Journal of Organic Chemistry, 2019, 84, 14, 8959-8975.                                                                                                             
  12. Subhendu Pramanik, Moumita Jash, Debasmita Mondal, Chinmay Chowdhury*; “Palladium‐Catalyzed Synthesis of 6H‐Dibenzo[c,h]chromenes and 5,6‐Dihydrobenzo[c]phenanthridines: Application to the Synthesis of Dibenzo[c,h]chromene‐6‐ones, Benzo[c]phenanthridines, and Arnottin I”, Advanced Synthesis and Catalysis, 2019, 361, 5223– 5238;  (doi : 10.1002/adsc.201900833).
  13. Debasmita Dutta, Brahamacharry Paul, Biswajit Mukherjee, Laboni Mondal, Suparna Sen, Chinmay Chowdhury and Mita Chatterjee Debnath; “Nanoencapsulated betulinic acid analogue distinctively improves colorectal carcinoma in vitro and in vivo” Scientific Reports, 2019, 9:11506 (htps://doi.org/10.1038/s41598-019-47743-y). (A publication from Nature group of journals).                                                  
  14. Swadesh Sarkar, Priya K. Gopal, Biswajit Chakraborty, Mausumi Paul, Chinmay Chowdhury, Santanu Paul; “14 Deoxy 11,12 Didehydroandrographolide: A Novel Compound Isolated from Andrographis paniculata Nees. Induces Robust Apoptosis in Leukemic Cells”, Pharcognosy Mag., 2019, 15, 135-143.
  15. Amrita Mondal, Priyanka Kundu, Chinmay Chowdhury*; “Palladium-catalysed stereoselective synthesis of 4-(diarylmethylidene)-3,4-dihydroisoquinolin-1(2H)-ones: expedient access to 4-substituted isoquinolin-1(2H)-ones and isoquinolines”,  Organic and Biomolecular Chemistry, 2018, 16, 963-980.  
  16. Moumita  Jash, Bimolendu Das,  Chinmay Chowdhury*; “Intramolecular  Cycloaddition Approach to Fused Pyrazoles: Access to 4,5-Dihydro-2H-Pyrazolo[4,3-c]quinolines, 2,8-Dihydro- indeno[2,1-c]pyrazoles and 4,5-Dihydro-2H-benzo[e]indazoles”, Synthesis, 2018, 50, 1511-1520. 
  17. Moumita Jash, Bimolendu Das,  Chinmay Chowdhury*; “One-Pot Access to Benzo[a]carbazoles via Palladium(II)-Catalyzed Hetero- and Carboannulations”, Journal of Organic Chemistry, 2016, 81, 10987-10999 .
  18. Priyanka Kundu, Amrita Mondal,  Chinmay Chowdhury*; “A Palladium-Catalyzed Method for the Synthesis of 2-(α-Styryl)-2,3-dihydroquinazolin-4-ones and 3-(α-Styryl)-3,4-Dihydro-1,2,4-benzothiadiazine-1,1-dioxide: Access to 2-(α-Styryl)quinazolin-4(3H)-ones and 3-(α-Styryl)-1,2,4-benzothiadiazine-1,1-dioxides”, Journal of Organic Chemistry, 2016,   81, 6596-6608 .
  19. Debasmita Dutta, Biswajit Chakraborty, Ankita Sarkar, Chinmay Chowdhury,  Padma Das;  “A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells”; BMC Cancer, 2016,  16: 23 (DOI: 10.1186/s12885 -016-2055-1).
  20. Priyanka Kundu, Amrita Mondal, Bimolendu Das, Chinmay Chowdhury*; “A Straightforward Approach for the stereoselective synthesis of (E)-2-aryl/vinylmethylidene-1,4-benzodiazepines and 1,4-benzodiazepin-5-ones through palladium/charcoal-catalyzed reactions”- Advanced Synthesis and Catalysis, 2015,  357,  3737-3752. 
  21. Deepak Kumar, Bimolendu Das, Rupashree Sen, Priyanka Kundu, Alak Manna, Avijit  Sarkar, Chinmay Chowdhury, Mitali Chatterjee,  Padma Das;  “Andrographolide analogue induces apoptosis and autophagy mediated cell death in U937 cells by inhibition of PI3K/Akt/mTOR pathway”,  PLoS One, 2015,  10(10):  e0139657 (DOI: 10.1371/journal.pone.0139657).
  22. Biswajit  Chakraborty, Deblina Dutta, Sanjukta Mukherjee, Supriya Das, Nukul C. Maiti, Padma Das* and Chinmay Chowdhury*;  “Synthesis and biological evaluation of a novel betulinic acid derivative as inducer of apoptosis in human colon carcinoma cells (HT-29)” European Journal of Medicinal Chemistry, 2015, 102, 93-105.
  23. Debasmita  Dutta, Ankita  Sarkar, Biswajit Chakraborty, Chinmay Chowdhury,  Padma Das;    “Induction of apoptosis by a potent betulinic acid derivative in human colon carcinoma HT-29 cells”,   International Journal of Scientific and Research Publications, 2015,  vol. 5, issue 2, ISSN 2250-3153.
  24. Ranjan Preet, Biswajit Chakraborty, Sumit Siddharth, Purusottam Mohapatra, Dipon Das, Shakti Ranjan Satapathy, Supriya Das, Nakul C. Maiti,  Prakas R. Maulik,  Chanakya Nath Kundu, Chinmay Chowdhury*; “Synthesis and biological evaluation of andrographolide analogues as anti-cancer agents,” Eurpopean Journal of Medicinal Chemistry, 2014,  85, 95-106. 
  25. Kaushik Brahma, Bimolendu Das, Chinmay Chowdhury*; “A palladium catalyzed facile and general method for the stereoselective synthesis of (E)-3-arylidene-3,4-dihydro-2H-1,4-benzoxazines and their naphthoxazine analogues”, Tetrahedron, 2014,  70, 5863-5871. 
  26. Bimolendu Das, Priyanka Kundu, Chinmay Chowdhury*; “Facile synthesis of 2-arylmethylindoles and 2-vinylic indoles through palladium-catalyzed heteroannulations of 2-(2-propynyl)aniline and 2-(2-propynyl)tosylanilides”-, Organic and Biomolecular Chemistry, 2014, 12, 741-748 (appeared as  cover page  of the journal). 
  27. Rajneeta Roy, Deepak Kumar, Biswajit Chakraborty, Chinmay Chowdhury,  Padma Das; “Apoptotic and autophagic effects of Sesbania grandiflora flowers in human leukemic cells”- Plos One, 2013  8, e71672. 
  28. Kaushik Brahma, Basudeb Achari, Chinmay Chowdhury*; “An efficient, general method for the synthesis of 1, 2, 3-triazole-fused heterocycles through palladium-catalyzed reactions”, Synthesis, 2013, 545-555. 
  29. Rajneeta Roy, Deepak Kumar, Chinmay Chowdhury, Padma Das; “Autophagic and apoptotic mechanisms of death induced by Sesbania grandiflora flowers in human leukemic cells”, European Journal of Cancer, 2012, 48, S-27.
  30. Padma das, Deepak kumar, Chinmay Chowdhury, Mitali Chatterjee; “Andrographolide Analogue Induces Apoptosis and Autophagy mediated cell death in U937 cells”, European Journal of Cancer, 2012, 48, S-156.
  31. Chinmay Chowdhury*, Bimolendu Das, Sanjukta Mukherjee, Basudeb Achari; “Palladium Catalyzed Approach for the General Synthesis of (E)-2-Arylmethylidene-N-tosyl-indolines and (E)-2-Arylmethylidene-N-tosyl/nosyl-tetrahydroquinolines: Access to 2-Substituted Indoles and Quinolines” Journal of Organic Chemistry, 2012, 77, 5108-5119.                                                                                                   
  32. Kaushik Brahma, Anup kumar Sasmal, Chinmay Chowdhury*; “An efficient strategy  for the general synthesis of 3-aryl substituted pyrazolo[5,1-c][1,4]benzoxazines and pyrazolo[1,5-a][1,4]benzodiaze- pin-6(4H)-ones”, Organic and Biomolecular Chemistry, 2011, 9, 8422-8429.                       
  33. Chinmay Chowdhury*, Sanjukta Mukherjee, Biswajit Chakraborty and  Basudeb Achari; “A Rapid and Facile Method For the General Synthesis of 3-Aryl Substituted 4,5,6,7-Tetrahydro-[1,2,3]triazolo[1,5-a]pyrazines and Their Ring Fused Analogues”,  Organic and Biomolecular Chemistry, 2011,  5856-5862. 
  34. Chinmay Chowdhury*, Anup Kumar Sasmal, and Basudeb Achari; “An Expedient and Facile  Route for the General Synthesis of 3-Aryl Substituted 1,2,3-Triazolo[1,5-a][1,4]benzodiazepin-6-ones and 1,2,3-Triazolo[1,5-a][1,5]benzodiazocin-7-ones”,  Organic and Biomolecular Chemistry, 2010, 8, 4971-4977. 
  35. Bimolendu Das, Chinmay Chowdhury*, Deepak Kumar, Rupashree Sen, Rajneeta Roy,  Padma Das, and Mitali Chatterjee; “Synthesis, Cytotoxicity, and Structure-activity Relationship (SAR) Studies of Andrographolide Analogues as Anti-cancer Agent”, Bioorganic and Medicinal Chemistry Letters, 2010,  20,  6947-6950. 
  36. Chinmay Chowdhury*, Kaushik Brahma, Sanjukta Mukherjee, and Anup Kumar Sasmal; “Totally Regio- and Stereoselective Synthesis of (E)-3-Arylidene-3,4-dihydro-2H-1,4-benzoxazines under Palladium Catalyst”,  Tetrahedron Letters, 2010,   51, 2859-2861.                                   
  37. Chinmay Chowdhury*, Sanjukta Mukherjee, Bimalendu Das, Basudeb Achari; “Expedient and Rapid Synthesis of 1,2,3-Triazolo[5,1-c]morpholines through Palladium-copper Catalysis” Journal of Organic Chemistry, 2009,  74, 3612-3615.                                                             
  38. Chinmay Chowdhury*, Anup kumar Sasmal, Pradeep Kumar Dutta; “Efficient Synthesis of [1,2,3]-triazolo[5,1-c][1,4]benzoxazines through Palladium-copper Catalysis” Tetrahedron Letters, 2009, 50, 2678-2681.                       
  39. Vandana Srivastava, Mahendra P. Darokar, A. Fatima, J.K. Kumar, Chinmay Chowdhury, Hari Om Saxsena, Gaurav R. Dwivedi, Kunal Srivastava, Vivek Gupta, S.K. Chattopadhya, Suman P.S. Khanuja; “Synthesis of the Diverse Analogues of Oenostacin and their Anti-bacterial Activities” Bioorganic & Medicinal Chemistry, 2007, 15, 518-525.                                                                 
  40. Chinmay Chowdhury*, Sukhendu B. Mandal, Basudeb Achari; “Palladium-Copper Catalysed Heteroannulation of Acetylenic Compounds: An Expeditious Synthesis of Isoindoline Fused with Triazoles, Tetrahedron Letters, 2005, 46, 8531-8534.
  41. Basudeb Achari, Sukhendu B. Mandal, Pradeep Dutta, Chinmay Chowdhury*; “Perspectives on     1, 4-Benzodioxions, 1, 4-Benzoxazines and Their 2, 3-Dihydro Derivatives”, SYNLETT, 2004, 14, 2449-2467. 
  42. Ta-Hsiang Chao, Thanh Lam, Binh G. Vong, Paqui G. Traves, Sonsoles Hortelano, Chinmay Chowdhury, F. Rena Bahjat , G. Kenneth Lloyd, Lyle L Moldawer, Lisardo Bosca, Michael A. Palladino, Emmanuel A. Theodorakis*; “A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis  by Inhibiting lκBα phosphorylation, Chembiochem, 2005,  6, 133-144.                          
  43. Thanh Lam, Taotao Ling, Chinmay Chowdhury, Ta-Hsiang Chao, F. R. Bahjat, G. K. Lloyd, Lyle L. Moldawer, Michael A. Palladino and Emmanuel. A. Theodorakis*; “Synthesis of a Novel Family of Diterpenes and their Evaluation as Anti-inflammatory Agents”,   Bioorganic & Medicinal Chemistry Letters, 2003, 13, 3217-3221.                                                                                                                       
  44. Erik. J. Tisdale, Bingh G. Vong, Hongmei Li; Sun Hee Kim, Chinmay Chowdhury and Emmanuel A. Theodorakis*; “Total Synthesis of Seco-lateriflorone”, Tetrahedron, 2003, 59, 6873-6887.                                                         
  45. Erik J. Tisdale, Chinmay Chowdhury, Binh G. Vong, Hongmei Li, and Emmanuel A. Theodorakis*; Regioselective Synthesis of the Bridged Tricyclic core of Garcinia Natural Products via Intramolecular Aryl Acrylate Cycloadditions,  Organic Letters, 2002, 909-912.                                 
  46. Taotao Ling, Chinmay Chowdhury, Bryan A. Kramer, Binh Vong, Michael A. Palladino and Emmanuel A. Theodorakis*;  “Enantioselective Total Synthesis of the Anti-inflammatory Agent (-)-Acanthoic Acid,  Journal of Organic Chemistry, 2001,  26, 8843-8854.                                   
  47. Nitya G. Kundu*, Jyan S. Mahanty, Chinmay Chowdhury, Swapan   Dasgupta, Biswajit Das, C. Paul Spears, Jan Balzarini and Erik De Clercq; “5-(Acylethnyl)uracils, 5-(Acylethnyl)-2’-deoxyuridines and 5-(Acylethnyl)-1-(2-hydroxyethoxy)methyluracils. Their Synthesis, Antiviral and Cytotoxic Activities European Journal of Medicinal Chemistry, 1999, 389-399.                                                             
  48. Chinmay Chowdhury and Nitya G. Kundu*; “Studies on Copper (I) Catalysed Cross Coupling Reactions- A Convenient and Facile Method for the Synthesis of Diversely Substituted , ß-Acetylenic Ketones Tetrahedron, 1999,   55, 7011-7016.                                                       
  49. Gopeswar Chaudhuri, Chinmay Chowdhury,  Nitya  G. Kundu*; “A Highly Stereoselective Synthesis of (Z)-N-Arylidine-2,3-dihydro-1,4-   Benzoxazines through Palladium-Catalysed Reactions” SYNLETT, 1998, 1273-1275.         
  50. Chinmay Chowdhury, Gopeswar Chaudhuri, Subhdra Guha,  Alok K. Mukherjee, and Nitya G. Kundu*; “Palladium-Catalyzed Heteroannulation Leading to Heterocyclic Structures with two Hetero Atoms: A Highly Convenient and Facile Method for a Totally Regio- and Stereoselective Synthesis of (Z)-2,3-Dihydro-2-(ylidiene)-1,4-Benzo- and Naptho[2,3-b]dioxins” Journal of Organic Chemistry, 1998,  63, 1863-1871.
  51. Chinmay Chowdhury and Nitya G. Kundu*; “Copper (I) Catalysed Acylation of Terminal Alkynes” Tetrahedron Letters, 1996, 37, 7323-7324.
  52. Chinmay Chowdhury and Nitya G. Kundu*; “A Totally Stereoselective Synthesis of (Z)-2-Arylidine-1, 4-benzodioxans using Palladium-Copper Catalyst”, Chemical Communications, 1996, 1067-1068.                      
  53. Nitya G. Kundu*, Manojit Pal and Chinmay Chowdhury; “A Highly Simplified Approach for the Synthesis of ß-aryl Substituted Conjugated Acetylenic Ketones Meditated through Palladium-Copper Catalysis”, J. Chem .Res. (S), 1995, 4-5. 
  54. Nitya G. Kundu*, Monojit Pal and Chinmay Chowdhury; “A Highly Convenient and General Method for the Synthesis of 1, 4-Disubstituted-1, 3-diynes from Terminal Alkynes through Palladium-Copper Catalyst”,   J. Chem Res., 1993, 432-433.
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