Amit Kumar Srivastava, Ph.D.

Cancer Biology & Inflammatory Disorder

Research Interest

  • Exploring drug resistance mechanisms in cancer stem cells
  • Mechanisms and targeting of cancer stem cell plasticity
  • DNA damage and repair
  • miRNAs and their role in Cancer
  • Nanoparticles mediated drug-delivery


  • Ramalingaswami Fellow (April 2018-present)
  • Scientist, (October 2017-April 9, 2018) CSIR-North East Institute of Science and Technology (CSIR-NEIST), Jorhat
  • Post-Doctoral Fellow (July 2013-September 2017), The Ohio State University, Columbus, Ohio, USA
  • PhD (2008-2013) CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow

Honours & Awards

  1. Ramalingaswami fellowship award, Department of Biotechnology (DBT) (2017)
  2. Ramanujan Fellowship award, Science and Engineering Research Board (SERB-DST) (2017)
  3. Attended Nobel Prize series 2018 at RashtrapatiBhawan
  4. Best Postdoc Poster award by The Ohio State University, USA 2016
  5. Pelotonia Postdoctoral Fellowship 2014 by The Ohio State University, USA
  6. Young Scientist Award in XXXII Annual Meeting of Society of Toxicology (STOX), 2012, India.
  7. Seth Roop Lal Aggrawal Gold medal by Society of Toxicology (STOX), 2012, India.
  8. Best paper award by Environmental Mutagen Society of India (EMSI), 2010.
  9. Joint CSIR-UGC Junior Research Fellowship: CSIR New Delhi, India (2007)
  10. Qualified Graduate Aptitude Test in Engineering (GATE), 2006

Patents & Publications

  1. Saha P, Mandal T, Talukdar AD, Kumar D, Kumar S, Tripathi PP, Wang QE, Srivastava AK. DNA polymerase eta: A potential pharmacological target for cancer therapy. J Cell Physiol, 2020 (in press). PMID: 33184862
  2. Kumar S, Behera A, Saha P, Srivastava AK. The role of Krüppel-Like Factor 8 in cancer biology: current research and its clinical relevance. Biochemical Pharmacology 2020 (in press).
  3. Dey J, Alam MT, Chandra S, Gupta J, Ray U, Srivastava AK, Tripathi PP. Neuroinvasion of SARS‐CoV‐2 may play a role in the breakdown of the respiratory center of the brain. J Med Virol. 2020 (in press). PMID: 32964419
  4. Chatterjee B, Saha P, Bose S, Shukla D, Chatterjee N, Kumar S, Tripathi PP and  Srivastava AK. MicroRNAs: As Critical Regulators of Tumor- Associated Macrophages. Int. J. Mol. Sci. 2020, 21(19), 7117, 2020. PMID: 32992449
  5. Behera A, Ashraf R, Srivastava AK, Kumar S. Bioinformatics analysis and verification of molecular targets in ovarian cancer stem-like cells. Heliyon (Cell press). 6 (9), e04820, 2020. PMID: 32984578
  6. Saha P, Banerjee AK, Tripathi PP, Srivastava AK*, Ray U. A virus that has gone viral: amino acid mutation in S protein of Indian isolate of coronavirus COVID-19 might impact receptor binding, and thus, infectivity. Biosci Rep. 40(5):BSR20201312, 2020. (*Co-corresponding). PMID: 32378705
  7. Gandhi S, Srivastava AK*, Ray U, Tripathi PP .Is the collapse of the respiratory center in the brain responsible for respiratory breakdown in COVID-19 patients? ACS Chem Neurosci.  11(10):1379-1381, 2020 (*Co-corresponding). PMID: 32348111
  8. Chandra S, Alam T, Dey J, Chakrapani P, Srivastava AK, Gandhi S and Tripathi PP. Healthy gut, healthy brain: The gut microbiome in neurodegenerative disorders. Current Topics in Medicinal Chemistry.  20(13):1142-1153, 2020. PMID: 32282304
  9. Srivastava AK*, Banerjee A*, Cui T*, Han C, Cai S, Liu L, Wu D, Cui R, Li Z, Zhang X, Xie G, Selvendiran K, Patnaik S, Karpf AR, Liu J, Cohn DE and Wang QE. Inhibition of miR-328–3p impairs cancer stem cell function and prevents metastasis in ovarian cancer. Cancer Research 2019, 79(9):2314-2326, 2019 (*equal contribution). PMID: 30894370
  10. Cui T*, Srivastava AK*, Han C, Wani N, Liu L, Gao Z, Qu M, Zou N, Zhang X, Yi P, Yu J, Bell E, Yang SM, Maloney D, Zheng Y, Wani A, Wu D and Wang Qi-en. DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1. Cell death and disease 9(5):561, 2018 (*equal contribution). PMID: 29752431
  11. Srivastava AK*, Rizvi A*, Cui T, Han C, Banerjee A, Naseem I, Zheng Y, Wani A and Wang Qi-en. Depleting ovarian cancer stem cells with calcitriol. Oncotarget. 16;9(18):14481-14491, 2018. (*equal contribution). PMID: 29581858
  12. Zhou G, Yang L, Gray A, Srivastava AK, Li C, Zhang G, Cui T. The role of desmosomes in carcinogenesis. Onco Targets Ther. 10:4059-4063, 2017. PMID: 28860814.
  13. Srivastava AK and Wang Qi-en. Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy. Molecular & Cellular Oncology   3(1): e1043482, 2016. PMID: 27308560
  14. Srivastava AK*, Mishra S* and Shukla Y. Protective effects of lupeol against mancozeb-induced genotoxicity in cultured human lymphocytes via inhibition of NF-κB mediated oxidative stress Phytomedicine 23(7):714-24 2016 (*equal contribution) PMID:27235710.
  15. Zou N, Xie G, Cui T, Srivastava AK, Qu M, Yang L, Wei S, Zheng Y, Wang QE. DDB2 increases radioresistance of NSCLC cells by enhancing DNA damage responses. Tumour Biol. 2016 Oct;37(10):14183-14191. PMID: 27553023
  16. Mishra S, Rai G, Srivastava AK, Singh AK, Ahmad A, Suman S, Singh M, Reddy MKR, Tiwari BN, Gupta P, Gaur VK, Srivastava VK, Kumar V, Shukla Y. miR-34a Overexpression Induces Senescence Associated Secretory Phenotypes in Doxorubicin induced Pseudo-Senescent Triple Negative Breast Cancer cells via SOCS4-IL6-STAT3 axis. American Journal of Cancer Research 2017 (in press)
  17. Srivastava AK, Han C, Zhao R, Cui T, Dai Y, Mao C, Zhao W, Yu J and Wang Qi-en. Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells in Proceedings of the National Academy of Sciences U.S.A.   7;112(14):4411-6, 2015. PMID: 25831546
  18. Han C, Srivastava AK, Cui T, Wang QE, Wani AA. Differential DNA lesion formation and repair in heterochromatin and euchromatin. Carcinogenesis. 37(2):129-138 2015. PMID: 26717995.
  19. Qu MH, Han C, Srivastava AK, Cui T, Zou N, Gao ZQ, Wang QE. miR-93 promotes TGF-β-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells. Tumour Biol.37(4):5645-51 2015. PMID: 26581907
  20. Mishra S, Srivastava AK, Suman S and Shukla Y. Circulating miRNAs revealed as surrogate molecular signatures for the early detection of breast cancer in Cancer letter. 1; 369(1):67-75, 2015, PMID: 26276721.
  21. Zhao R, Han C, Zhang X, He J, Srivastava AK and Wani A and Wang Qi-en,. DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L. Nucleic Acid Research. 18; 43(16):7838-49, 2015. PMID: 26130719.
  22. Cui T, Srivastava AK, Han C, Yang L, Zhao R, Zou N, Qu M, Duan W, Zhang X and Wang Qi-en. XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression. Oncotarget. 30;6(12):10060-72, 2015. PMID: 25871391
  23. Jiang Q, Pentz K, Zhu Q, Wang Qi-en, He J, Srivastava AK and Wani A. USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability. Oncogene. 3;34(36):4791-6, 2014, PMID: 25435364.
  24. Bhatnagar P, Patnaik S, Srivastava AK, Mudiam KRM, Shukla Y, Panda AK, Pant AB, Kumar P, and Gupta KC. Anti-Cancer Activity of Bromelain Nanoparticles by Oral Administration. Journal of Biomedical Nanotechnology 10(12):3558-75, 2014. PMID: 26000370
  25. Han C, Zhao R, Liu X, Srivastava AK, Gong L, Mao H, Qu M, Zhao W, Yu J, Wang Qi-en. DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer. Molecular Cancer Research. 12(5):784-94, 2014. PMID: 24574518.
  26. Srivastava AK, Singh M, Bhatnagar P, Mishra S, Kumar P, Shukla Y, Gupta KC, Synthesis of PLGA nanoparticles of tea polyphenols and their strong in vivo protective effect against chemically induced DNA damage. International Journal of Nanomedicine. 8:1451-62. PMID: 23717041
  27. George J, Singh M, Srivastava AK, Bhui K, Shukla Y. Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: evidence for inhibition of activated MAPKs/NF-ĸB and reduced cell proliferation. Food and Chemical Toxicology. 49(7):1511-2, 2011. PMID: 21443920
  28. Bhui K, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y. Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis. Molecular Carcinogensis. 51(3):231-43, 2011. PMID: 21432909