Suvendra Bhattacharyya , Ph.D., FNA, FNASc., FASc., FAScT

Chief Scientist , Professor of Molecular Biology and Biochemistry, AcSIR Swarnajayanti Fellow, Department of Science and technology, Govt. of India
Molecular Genetics

Research Interest

  • Mechanism of Extracellular Vesicles (EVs) mediated export of miRNA and its role in disease process.
  • Importance of subcellular structures and organelles in post-transcriptional regulation of gene expression in human cells
  • Effect of cellular microenvironment on miRNA-mediated gene regulation in mammalian cells.
  • Role of host cell miRNAs and other post-transcriptional factors in regulation of parasitic infection of mammalian cells


  • HOD, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Calcutta, India
  • 2004-2008: EMBO and HFSPO Post-Doctoral Research Fellow at Friedrich Miescher Institute, Basel, Switzerland
  • 2003: PhD, Jadavpur University, Kolkata 
  • 1998-2003: Research Fellow, CSIR-Indian Institute of Chemical Biology, Calcutta, India

Honours & Awards

  • 2022: Featured in in the book '75 under 50 Scientists Shaping Today's India' by Dept. of Science and Technology, Govt. of India and VIGYAN PRASAR 
  • 2021: Sun Pharma Research Award in Medical Sciences -Basic Research
  • 2018: Khosla national Award in Science and Humanities
  • 2017: CDRI Award for Excellence in Drug Research
  • 2016: Shanti Swarup Bhatnagar Prize in Biological Sciences
  • 2015: National Bioscience Award
  • 2015: NASI-Scopus Award
  • 2014-2015: Swarnajayanti Fellow, Dept. of Science and Technology, Govt. of India
  • 2009-2014: International Senior Research Fellow, The Wellcome trust, London
  • 2008-2012: Career Development Awardee of the International Human Frontier Science Program Organization
  • Fellow of Indian National Science Academy (FNA)
  • Fellow of Indian Academy of Sciences (FASc)
  • Fellow of the National Academy of Sciences, India (FNASc)
  • Fellow of the West Bengal Academy of Science and Technology (FAScT)
  • Member of Guha Research Conference
  • 2004: AAAS/Science-GE healthcare Young Scientist Award, USA 
  • 2004: INSA Young Scientist award, INDIA

Grants & Supports

  • 2016 - Swarnajayanti Fellowship Fund from Dept. of Science and Technology, Principal Investigator, Duration: 5 Years, Amount: 19,000,000 INR
  • 2016 - High Risk High Reward Project Grant from Science and Engineering Research Board, Dept. of  Science and Technology, Principal Investigator,  Duration: 3 Years, Amount: 15,000,000 INR
  • 2016 - National Bioscience Award Grant from Dept. of Biotechnology Govt of India, Principal Investigator, Duration: 3 Years, Amount: 1,500,000 INR 
  • 2018 - National Bioscience Award Grant Indo-Swiss Bilateral Joint Research Project from Dept. of Biotechnology Govt of India, Principal Investigator, Duration: 4Years, Amount: 19,000,000 INR; Swiss Collaborator: Mihaela Zavolan,    Biozentrum, University of Basel.   
  • 2019 - CEFIPRA Indo-French Joint Research Fund, Principal Investigator, Duration: 3 Years, Amount: 6,000,000 INR; French Collaborator: Edouard Bertrand, IGMM; CNRS Montpellier

Patents & Publications

Patents & Key Publications:

  1. Chatterjee, S., Mukherjee, I., Bhattacharjee, S., Bose, M., Chakrabarti, S. and Bhattacharyya, S.N. (2022) Target-Dependent Coordinated Biogenesis of secondary microRNAs by miR-146a balances macrophage activation processes. Mol Cell Biol.  e0045221. 
  2. Ganguly, S. Ghoshal, B., Banerji, I., Bhattacharjee, S. Chakraborty, S, Goswami, A., Mukherjee, K. and Bhattacharyya, S.N.  (2022) Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation. Life Sci Alliance. 5(6)pii: e202101229.
  3. Das, A., Basu, S.,  Bandyopadhyay, D., Mukherjee, K., Dutta, D., Chakrabarti, S., Adak, M., Jana, S., Bose, S., Swarnakar, S.,   Chakrabarti, P. and   Bhattacharyya, S. N.  (2021) Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Transfer of Hepatic miR-122 to Tissue Macrophages and Curtails Liver Inflammation. iScience 12(24) 103428.
  4. De, D., and Bhattacharyya, S. N. (2021) Amyloid Beta oligomers prevents Lysosomal targeting of miRNP to stop its recycling and target repression in glial cells. J Cell Sci. 134(11) jcs.258360. (Cover Article)
  5. De, D., Mukherjee, I., Guha, S., Paidi, R. K., Chakrabarti, S., Biswas, S. C., and  Bhattacharyya, S. N. (2021) Rheb-mTOR Activation Rescues Amyloid Beta-Induced Cognitive Impairment and Memory Function by Restoring miR-146 Activity in Glial Cells. Molecular Therapy-Nucleic Acids. (24) 868-887. (Cover Article)
  6. Ghoshal, B., Bertrand, E., and Bhattacharyya, S. N. . (2021) Non-canonical argonaute loading of extracellular vesicle-derived exogenous single-stranded miRNA in recipient cells. J Cell Sci. 134(9) jcs253914 
  7. Ghosh, S., Mukherjee, K., Chakrabarty, Y., Chatterjee, S., Ghoshal, B., & Bhattacharyya, S. N. (2021) GW182 Proteins Restrict Extracellular Vesicle-Mediated Export of miRNAs In Mammalian Cancer Cells. Mol. Cell. Biol. 41 (5). e00483-20. (Cover Article)
  8. Chatterjee, S., Chakrabarty, Y., Banerjee, S., Ghosh, S. and Bhattacharyya, S. N. (2020) Mitochondria Controlled mTORC1 Activation Compartmentalizes Translation Initiation Factor eIF4E to Augment Intracellular Trafficking and Extracellular Export of miRNA in Mammalian Cells. J Cell Sci. 133(24) jcs250241. IF: 4.5 (Cover Article)
  9. Mukherjee, B., Mukherjee, K., Nanda, P., Mukhopadhayay, R., Ravichandiran, V., Bhattacharyya, S.N., Roy S. (2020) Probing the molecular mechanism of aggressive infection by antimony resistant Leishmania donovani. Cytokine. Aug 26:155245. Online ahead of print. IF: 3.5 “ Co-corresponding authors
  10. Ghosh, S., Chakraborty, J., Goswami, A., Bhowmik, S., Roy, S., Ghosh, A., Dokania, S., Kumari, P., Datta, S., Chowdhury, A., Bhattacharyya, S.N., Chatterjee, R., Banerjee, S. (2020) A novel microRNA boosts hyper-β-oxidation of fatty acids in liver by impeding CEP350-mediated sequestration of PPARα and thus restricts chronic hepatitis C. RNA Biol. 2020 Sep;17(9):1352-1363. 
  11. Goswami A, Mukherjee K, Mazumder A, Ganguly S, Mukherjee I, Chakrabarti S, RoyS, Sundar S, Chattopadhyay K, Bhattacharyya SN. (2020) MicroRNA exporter HuR clears the internalized pathogens by promoting pro-inflammatory response in infected macrophages. EMBO Mol Med. Feb 7:e11011. 
  12. Bose M, Chatterjee S, Chakrabarty Y, Barman B, Bhattacharyya SN.(2020)  Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum-attached polysomes in mammalian cells  Life Sci Alliance. 3(2)pii: e201800161. 
  13. Bose, M., Bhattacharyya, S.N. (2018) Target mRNA-Driven Biogenesis of Cognate MicroRNAs In Vitro. Methods in Mol Biol  1733:27-39.
  14. Patranabis S, Bhattacharyya SN. P-body-induced inactivation of let-7a miRNP prevents the death of growth factor-deprived neuronal cells.(2017) FASEB J. [Epub ahead of print]
  15. Chakrabarty, Y, Bhattacharyya S.N.(2017). Leishmania donovani restricts mitochondrial dynamics to enhance miRNP stability and target RNA repression in host macrophages. Mol Biol Cell. 28:1091-1105. (Cover Article).
  16. Bose, M., Barman, B., Goswami, A., Bhattacharyya, S.N.(2017).Spatiotemporal Uncoupling of MicroRNA-Mediated Translational Repression and Target RNA Degradation Controls MicroRNP Recycling in Mammalian Cells. Mol Cell Biol. 37: pii:e00464-16.
  17. Mukherjee, K., Ghoshal, B., Ghosh, S., Chakrabarti, Y., Swetha, S., Das, S. and Bhattacharyya, S.N., (2016). Reversible HuR-microRNA binding controls extracellular export of miR-122 & augments stress response. EMBO Rep. 17: 1184-1203.(Faculty 1000 Prime Article).
  18. Bose, M. and Bhattacharyya, S.N., (2016). Target dependent biogenesis of cognate miRNAs in mammalian cells. Nat. commun.7:12200.
  19. Patranabis, S., Bhattacharyya, S.N., (2016). Phosphorylation of Ago2 and Subsequent Inactivation of let-7a miRNPs Control Differentiation of Mammalian Sympathetic Neurons. Mol. Cell. Biol. 36,1260-1271.
  20. Barman, B. and Bhattacharyya, S.N., (2015). mRNA targeting to Endoplasmic Reticulum precedes Ago protein interaction and miRNA-mediated translation repression in mammalian cells. J. Biol. Chem. 290, 24650-24656.
  21. Ghosh S., Bose M., Ray A., Bhattacharyya S.N., (2015). Polysome arrest restricts miRNA turnover by preventing their exosomal export in growth retarded mammalian cells. Mol. Biol. Cell. 26, 1072-1083.
  22. Basu, S. and Bhattacharyya, S.N., (2014). Insulin-like growth factor-1 prevents miR-122 production in neighbouring cells to curtail its intercellular transfer to ensure proliferation of human hepatoma cells. Nucleic Acids Res., 42, 7170-7185.
  23. Mazumder, A., Bose, M., Chakraborti, A., Chakrabarti, S. and Bhattacharyya, S.N., (2013). A transient reversal of miRNA-mediated repression controls macrophage activation. EMBO Rep., 14, 1008-1016.
  24. Ghosh, J., Bose, M., Roy, S., Bhattacharyya, S.N., (2013). Leishmania donovani Targets Dicer1to Downregulate miR-122, Lower Serum Cholesterol, and Facilitate Murine Liver Infection. Cell Host Microbe, 13, 277-288.(See Commentary:
  25. Kundu, P., Fabian, M.R., Sonenberg, N., Bhattacharyya, S.N.*, Filipowicz, W*., (2012). HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Res., 40, 5088-6000.* co-corresponding author
  26. Cougot, N*., Bhattacharyya, S.N*., Tapia-Arancibia, L., Bordonné R., Filipowicz, W., Bertrand E., and Rage, F., (2008). Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation. J. Neuroscience, 28, 13793-13804.* co-first author
  27. Filipowicz, W., Bhattacharyya, S.N., Sonenberg, N., (2008). Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet., 9, 102-114.
  28. Bhattacharyya, S.N., & Filipowicz W., (2007). Argonautes and company: sailing against the wind. Cell, 128, 1027-1028.
  29. Pillai, R.S., Bhattacharyya, S.N., & Filipowicz W., (2007). Repression of protein synthesis by miRNAs: How many mechanisms? Trends in Cell Biology, 17, 118-126.
  30. Bhattacharyya, S.N., Habermacher, R., Martine, U., Closs, E.I., & Filipowicz, W., (2006). Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell, 125, 1111-1124.
  31. Kotaja, N*., Bhattacharyya, S.N*., Jaskiewicz, L, Kimmins, S, Parvinen, M, Filipowicz, W., & Sassone-Corsi, P., (2006). The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc. Natl. Acad. Sci. U S A., 103, 2647-2652.* Co-first author
  32. Pillai, R.S., Bhattacharyya, S.N., Artus, C.G., Zoller, T., Cougot, N., Basyuk, E., Bertrand, E. & Filipowicz W., (2005). Inhibition of translational initiation by let-7 microRNA in human cells. Science, 309, 573-1576.