Arun Bandyopadhyay , Ph.D.

Chief Scientist & HOD
Cell Biology & Physiology

Research Interest

  1. Mechanism of dysfunctions of cardiomyocytes in hyperthyroid induced cardiovascular disease.
  2. Identification of altered gene expression profile in hypertrophied heart.
  3. Mechanism of ROS mediated inhibition of gene expression in hyperthyroid-induced hypertrophied heart.
  4. Ca2+ signaling in cardiomyocytes.
  5. Role of annexin A6 in the regulation of Ca2+ homeostasis in cardiomyocytes.
  6. Identification of biomarkers of heart diseases.
  7. Identification of single nucleotide polymorphism on the genes those are functionally important for heart function among various Indian populations.
  8. Screening synthetic and herbal sources for development of anti-asthmatic molecules.

Patents & Publications

  1. Banerjee N, Bandyopadhyay AK, Dutta S, Das JK, Roy Chowdhury T, Bandyopadhyay A, Giri AK. Increased microRNA 21 expression contributes to arsenic induced skin lesions, skin cancers and respiratory distress in chronically exposed individuals. Toxicology. 2017 Mar 1;378:10-16. doi: 10.1016/j.tox.2017.01.006. Epub 2017 Jan 6.
  2. Mukherjee S, Bandyopadhyay A. Proteomics in India: the clinical aspect. Clin Proteomics. 2016 Nov 5;13:21. eCollection 2016. Review.
  3. Ahmmed SM, Mukherjee PK, Bahadur S, Harwansh RK, Kar A, Bandyopadhyay A, Al-Dhabi NA, Duraipandiyan V. CYP450 mediated inhibition potential of Swertia chirata: An herb from Indian traditional medicine. J Ethnopharmacol. 2016 Feb 3;178:34-9. doi: 10.1016/j.jep.2015.11.046. Epub 2015 Nov 30.
  4. Ahmmed SM, Mukherjee PK, Bahadur S, Kar A, Mukherjee K, Karmakar S, Bandyopadhyay A. Interaction potential of Trigonella foenum graceum through cytochrome P450 mediated inhibition. Indian J Pharmacol. 2015 Sep-Oct;47(5):530-4. doi: 10.4103/0253-7613.165179.
  5. Mukherjee, S, Jagadeeshaprasad, MG, Banerjee T, Ghosh, SK, Biswas M, Dutta S, Kulkarni M, Pattari S, Bandyopadhyay A. Proteomic analysis of human plasma in Chronic Rheumatic Mitral Stenosis reveals proteins involved in the Complement and Coagulation cascade. Clin. Proteom. 2014 (in press).
  6. Banerjee P and Bandyopadhyay A. Cytosolic dynamics of annexin A6 triggers feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes. J.Biol.Chem. 2014, 289, 5371-5385.
  7. Banerjee T, Mukherjee, S, Ghosh, S, Biswas M, Dutta S, Pattari S, Chatterjee S, Bandyopadhyay A. Clinical Significance of Markers of Collagen Metabolism in Rheumatic Mitral Valve DiseasePLOS one. 2014, 9: e90527.
  8. Maity S, Kar D, De K, Chander V Bandyopadhyay A. Hyperthyroidism causes cardiac dysfunction by mitochondrial impairment and energy depletion. J. Endocrinol, 2013, 217:215-228.
  9. Banerjee T, Mukherjee, S, Biswas M, Dutta S, Chatterjee S, Pattari S, Nanda, S. Bandyopadhyay A. Circulating Carboxy-terminal Propeptide of Type I Procollagen is Increased in Rheumatic Heart DiseaseInt. J. Cardiology 2012, 156:117-119.
  10. Member of the The Indian Genome Variation Consortium. Aggarwal S, et. Al. Proc, Natl Acd Sci. USA 2010;107:18961-18966.
  11. Zhao W, Fan GC, Zhang ZG, Bandyopadhyay A, Zhou X and Kranias EG. Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic Res. Cardiol. 2009, 104(4):377-89.
  12. Ghose Roy S, Mishra S, Ghosh G and Bandyopadhyay A. Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase. Matrix Biol. 2007, 26:269-279.
  13. Ghosh G, De K, Maity S, Bandyopadhyay D, Bhattacharya S, Reiter RJ and Bandyopadhyay A. Melatonin protects against oxidative damage and restores GLUT4 expression in hyperthyroid rat heart. J. Pineal Res. 2007, 42:71-82.
  14. Mahata B, Mukherjee S, Mishra S, Bandyopadhyay A and Adhya S. Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells. Science. 2006, 314:471-474.
  15. De K, Ghosh G, Datta M, Konar A, Bandyopadhyay J, Bandyopadhyay D, Bhattacharya S and Bandyopadhyay A. Analysis of Differentially expressed genes in hyperthyroid-induced hypertrophied heart by cDNA microarray. J. Endocrinol. 2004, 182:304-314.
  16. Kim MJ, Jo DG, Hong GS, Kim BJ, Lai M, Cho DH, Kim KW, Bandyopadhyay A, Hong YM, Kim DH, Cho C, Liu LO, Snyder SH and Jung YK. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium triggered cell death. Proc. Natl. Acad. Sci. USA. 2002, 99:9870-9875.
  17. Shin DW, Pan Z, Bandyopadhyay A, Bhatt M, Kim DH and Ma J. Calcium dependent interaction between FKBP12 and calcineurin regulates activity of the Ca release channel in skeletal muscles. Biophys. J.2002, 83: 2539-2549.
  18. Bandyopadhyay A, Shin DW and Kim DH. Regulation of ATP-induced calcium release in COS-7 cells by calcineurinBiochem J2000, 348:173-181.
  19. Bandyopadhyay A, Shin DW, Ahn JO and Kim DH. Calcineurin regulates ryanodine receptor/Ca channels in rat heart. Biochem. J. 2000, 352:61-70.