Scientists
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- Dr. Motilal Maiti
- Dr. Alok Dutta
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Vision
Structure-function analysis of various biological macromolecules using multi-pronged approaches from different angles involving modern biological, chemical and physical technologies.
Objectives
- Characterisation of potentially prospective biological macromolecules and other small molecules of therapeutic interest against various diseases, e.g. leishmania, cholera, cancer, diabetes and for other anti-inflamatory, anticonvulsant and immunomodulatory activities.
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- Studies on protein-protein and protein-nucleic acid interactions applying modern sophisticated technologies like nuclear magnetic resonance (NMR), mass-spectrometry.
- Quantitative structure activity relationship (QSAR) and 3D-QSAR.
- Development of software for prediction, modification and analysis of macromolecular structures and for elucidating their interactions with bio-active molecules.
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Team Members - SRF/JRF/Project Assistant
Staff Members
Important P&I in the last 5 years
- Dutta, M., Delhi, P., Sinha, K.M., Banerjee, R.K. and Datta, A.K. (2001) Lack of abundance of cytoplasmic CsA-binding protein renders free-living Leishmania donovani resistant to cyclosporinA. J. Biol. Chem276, 19294-19300.
- Chakraborty, A., Das, I., Datta, R, Sen, B., Bhattacharya, D., Mandal, C.N. and Datta, A.K. (2002) A single-domain cyclophilin from Leishmania donovani reactivates soluble aggregates of adenosine kinase by isomerase-independent chaperone function. J. Biol. Chem 277, 47451-47460.
- Chakraborty, A., Sen, B., Datta, R. and Datta, A.K. (2004) Isomerase-Independent chaperone function of cyclophilin ensures aggregation prevention of adenosine kinase both in vitro and under in vivo conditions. Biochemistry 43, 11862-11872.
- Brahma, A. and Bhattacharyya, D. (2004) UDP-galactose 4-epimerase from Kluveromyces fragilis: Evidence for independent mutarotase site. Eur. J. Biochem.271, 58-68.
- Nayar, S., Brahma, A., Barat, B. and Bhattacharyya, D. (2004) UDP-galactose 4-epimerase from Kluveromyces fragilis: Analysis of its hysteretic behavior in catalysis. Biochemistry 43, 10212-10223.
- Brahma, A. and Bhattacharyya, D. (2004) UDP-galactose 4-epimerase from Kluveromyces fragilis: Existence of subunit independent functional site. FEBS Lett. 577, 27-34.
- Bagchi, M.C., Maity, B.C., and Bose, S (2004) QSAR of anti tuberculosis drugs of INH type using graphical invariants. J.Mol.Struc : Theochem 679, 179-186.
- Roy S, Semsey S, Liu M, Gussin GN, Adhya S. (2004) GalR represses galP1 by inhibiting the rate-determining open complex formation through RNA polymerase contact: a GalR negative control mutant. J.Mol Biol. 344, 669-18.
- Datta, R., Das, I., Sen, B., Chakraborty, A., Adak, S., Mandal, C.N. and Datta, A.K. (2005) Mutational analysis of the active site residues crucial for catalytic activity of adenosine kinase from Leishmania donovani. Biochem. J 387, 591-600.
- Maiti A, Roy S. (2005) Switching DNA-binding specificity by unnatural amino acid substitution. Nucleic Acids Res. 33, 5896-903.
- Guha S, Sahu K, Roy D, Mondal SK, Roy S, Bhattacharyya K.(2005) Slow solvation dynamics at the active site of an enzyme:implications for catalysis. Biochemistry 44, 8940-7.
- Roy S, Dimitriadis EK, Kar S, Geanacopoulos M, Lewis MS, Adhya S.(2005)
- Gal repressor-operator-hu ternary complex ::pathway of repressosome formation. Biochemistry 44, 5373-80.
- Datta AB, Roy S, Parrack P.(2005) Role of C-terminal residues in oligomerisation and stability of lambda CII : implications for lysius-lysogeny decision of the phage. J. Mol Biol. 345, 315-24.
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