The broad aims of the division are to understand the molecular genetic basis of diseases common in Indian populations, to study gene expression and function in pathogenic microorganisms, and to develop transgenic plants with improved characteristics.
Objectives
to decipher the molecular basis of the genomic instabilities in head and neck cancer (HNSCC) and to identify the putative tumor suppressor genes involved in the development of this cancer
to identify susceptibility alleles in Helicobacter pylori associated gastroduodenal diseases
to study the molecular pathogenesis of oral submucous fibrosis
to understand the molecular genetics of haemophilia, glaucoma, Wilson disease, and oculo-cutaneous albinism
to assess the health effects, genetic damage and genetic variants in populations exposed to arsenic through drinking water in West Bengal.
to test the antimutagenic and anicarcinogenic effects of black tea polyphenols theaflavins and thearubigins .
to identify differentially expressed V. cholerae genes following infection to host and their role in pathogenesis, and to study the response of human intestinal epithelial cells to V. cholerae infection
to study the molecular basis of the import of nuclear-encoded tRNAs into the mitochondria of the kinetoplastid protozoon Leishmania using a combination of biochemical and reverse genetic approaches
to identify, isolate and modify genes from non-host plants involved in self-defence mechanisms against pests, and to transfer them as bio-pesticides to host plants
Goswami, S., Dhar, G., Mukherjee, S., Mahata, B., Chatterjee, S., Home, P. and Adhya, S. (2006) A bi-functional tRNA import receptor from Leishmania mitochondria Proc. Natl. Acad. Sci. USA, 103, 8354-8359.
Mahata, B., Bhattacharyya, S.N., Mukherjee, S. and Adhya, S. (2005) Correction of translational defects in patient-derived mutant mitochondria by complex-mediated import of a cytoplasmic tRNA. J. Biol. Chem.280, 5141-5144.
Bhattacharyya, S.N. and Adhya, S. (2004) tRNA-triggered ATP hydrolysis and generation of membrane potential by the Leishmania mitochondrial tRNA import complex. J. Biol. Chem.279, 11259-11263.
Ghosh, S., Goswami, S. and Adhya, S. (2003) Role of superoxide dismutase in survival of Leishmania within the macrophage. Biochem. J.369, 447-452.
Goswami, S., Chatterjee, S., Bhattacharyya, S. N., Basu, S. and Adhya, S. (2003) Allosteric regulation of tRNA import: interactions between tRNA domains at the inner membrane of leishmania mitochondria. Nucl. Acids Res. 31, 5552-5559.
Bhattacharyya, S.N., Chatterjee, S., Goswami, S., Tripathi, G., Dey, S.N. and Adhya, S. (2003) "Ping-Pong" interactions between mitochondrial tRNA import receptors within a multiprotein complex. Mol. Cell. Biol.23, 5217-5224.
Bhattacharyya, S.N., Chatterjee, S. and Adhya, S. (2002) Mitochondrial RNA import in Leishmania tropica: aptamers homologous to multiple tRNA domains that interact cooperatively or antagonistically at the inner membrane. Mol. Cell. Biol. 22, 4372-4382.
Mitra S., Sikdar N., Misra C., Gupta S., Paul R. R., Roy B., Panda C. K. and Roychoudhury S. Risk assessment of p53 genotypes and haplotypes in tobacco associated leukoplakia and oral cancer patients from eastern India. Int J Cancer 117: 786-793 (2005)
Chakrabarti S., Sengupta S., Sengupta A., Basak S. N., Roy A., Panda C. K. and Roychoudhury S. Genomic Instabilities in Squamous Cell Carcinoma of Head and Neck from the Indian Population. Mol. Carcinogenesis 45: 270-277 (2006)
Mondal G., Boral R. N. and Roychoudhury S. A new Mad2 interacting domain of Cdc20 is critical for the function of Mad2/Cdc20 complex in the spindle assembly checkpoint. Biochem. J. 396: 243-253 (2006)
Chakravorty M., Ghosh A., Choudhury A., Santra A., Hembrum J., Roychoudhury S. Interaction between IL1B gene promoter polymorphisms in determining susceptibility to
Helicobacter pylori associated duodenal ulcer. Human Mutation 27: 411-419 (2006)
Gupta A, Aikath D, Neogi R, Datta S, Basu K, Maity B, Trivedi R, Ray J, Das SK, Gangopadhyay PK, Ray K. Molecular pathogenesis of Wilson Disease: Haplotype analysis, detection of prevalent mutations and genotype-phenotype correlation in Indian patients, Human Genetics, 118, 49-57, 2005.
Chaki M, Sengupta M, Mukhopadhyay A, Subba Rao I, Majumder, PP, Das M, Samanta S, Ray K. OCA1 in different ethnic groups of India is primarily due to founder mutations in the Tyrosinase gene, Annals of Human Genetics, (Online publication date: 3-Mar-2006).
Association of adherence and motility in interleukin 8 induction in human intestinal epithelial cells by Vibrio cholerae.(2004). Sarkar M and Chaudhuri K. Microbes Infect. 6:676-685.
A novel wavelet-neural network-based pathological stage detection technique
for an oral precancerous condition. (2005). Paul RR, Mukherjee A, Dutta PK, Banerjee S, Pal M, Chatterjee J, Mukhopadhyay K and Chaudhuri, K. J Clin. Pathol. 58:932-8.
Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis. (2005). Sarkar, M. Das, S, Bandyopadhyay A, Ray, K and Chaudhuri, K. FEBS Lett 579 :3449-60.
Datta, K., Usha, R., Dutta, S. K. and Singh, M. (2001) A comparative study of the winged bean protease inhibitors and their interaction with proteases. Plant Physiol. Biochem.39, 949-959.
Ghosh, P., Basu, A., Mahata , J., Basu, S., Sengupta M.,, Das , J. K., Mukherjee, A., Sarkar, A. K., Mondal L. K., Ray , K. and Giri, A. K. (2006) Cytogenetic damage and genetic variants in the individuals susceptible to arsenic induced cancer through drinking water. Intl. J. Cancer 118(10): 2470-2478.
Anamika Basu., Arundhati Som., Sarbani Ghoshal., Lakshmikanta Mondal., Ramesh C. Chaubey., Hari N. Bhilwade., Mohammad M. Rahman and Ashok K. Giri (2005) Assessment of DNA damage in peripheral blood lymphocytes of individuals susceptible to arsenic induced toxicity in West Bengal, India. Toxicology Letters 159: 100-112.
Halder, B., Pramanick, S., Mukhopadhyay, S., Giri, A. K. (2005) Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems. Food Chem Toxicol. 43(4):591-597.
Basu, A., Ghosh, P., Das, J. K., Banarjee, A., Ray, K., Giri, A.K. (2004) Micronuclei as biomarkers of carcinogen exposure in populations exposed to arsenic through drinking water in West Bengal, India: a comparative study in 3 cell types. Cancer Epidemiology, Biomarkers and Prevention, 13: 820-827.
Mahata, J., Ghosh, P., Sarkar, J. N., Ray, K., Natarajan, A. T., Giri, A.K. (2004) Effect of sodium arsenite on peripheral lymphocytes in vitro: individual susceptibility among a population exposed to arsenic through the drinking water. Mutagenesis, 19: 1-7.
Mahata, J., Basu, A., Ghoshal, S., Sarkar, J. N., Roy, A. K., Poddar, G., Nandy, A. K., Banarjee, A., Ray, K., Natarajan, A. T., Nilsson, R., Giri, A.K. (2003) Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Res., 534: 133-143.
Basu, A., Mahata, J., Roy, A. K., Sarkar, J. N., Poddar, G., Nandy, A. K., Sarkar, P. K. Dutta, P. K., Banarjee, A., Das, M., Ray, K., Roychaudhury, S., Natarajan, A. K., Nilsson, R., Giri, A.K. (2002) Enhanced frequency of micronuclei in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Res., 516: 29-40.
Gupta, S., Saha, B. and Giri, A. K. (2002) Comparative antimutagenic and anticlastogenic effects of green tea and black tea: a review. Mutation Res., 512: 37-65.
Gupta, S., Chaudhuri, T., Ganguly, D. K. and Giri, A.K. (2001) Anticlastogenic effects of black tea (World blend) and its two active polyphenols theaflavins and thearubigins in vivo in Swiss albino mice. Life Sciences, 69: 2735-2744.
Basu, A., Mahata, J., Gupta, S. and Giri, A.K. (2001) Genetic toxicology of a paradoxical human carcinogen arsenic- a review. Mutation Res., 488: 171-194.
