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The Institute
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MAJOR ACHIEVEMENT IN IICB
Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells
Many maternally inherited and incurable neuromyopathies are caused by mutations in mitochondrial (mt) transfer RNA (tRNA) genes. Kinetoplastid protozoa, including Leishmania, have evolved specialized systems for importing nucleus-encoded tRNAs into mitochondria. We found that the Leishmania RNA import complex (RIC) could enter human cells by a caveolin-1-dependent pathway, where it induced import of endogenous cytosolic tRNAs, including tRNA(Lys), and restored mitochondrial function in a cybrid harboring a mutant mt tRNA(Lys) (MT-TK) gene. The use of protein complexes to modulate mitochondrial function may help in the management of such genetic disorders [Mahata B, Mukherjee S, Mishra S, Bandyopadhyay A & Adhya S, 2006, SCIENCE Oct 20; 314(5798): 471-474].
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PUBLICATIONS
A steady number quality publications is the hallmark of the Institute's progress in research.The statistics for the year 2005 – 2006 are:
Total number of publications in journals … 85
Average Impact Factor … … … 3.13
Publications in Books/Reviews … … 13 |
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PATENTS
Number of patents granted during the current year :
Number of national patents … 1
Number of international patents … 6
Total number of patents granted … 7
Number of patents filed during the current year :
Number of national patents … 9
Number of international patents … 3
Total number of patents filed … 12 |
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INDUSTRY-INSTITUTE TIE-UP: A NEW VENTURE
The Institute is continuously building synergy with the industries and successfully converting knowledge into wealth. This year also, the scientists have managed to sustain the same level of interaction with the industry and earn a considerable amount of resources both human and financial.
Our Partners for the overall growth towards a GATI-India regime are as follows :
- Angiogen Pharmaceuticals, Australia
- Merial SAS, Lyon, France
- Albert David Ltd., Kolkata
- Biotech Consortium (I) Ltd., New Delhi
- Chatterjee Management Services (P) Ltd., Kolkata
- Coir House, Kochi
- Dabur Research Foundation, Ghaziabad
- Dey’s Medical Stores (Mfg.) Ltd., Kolkata
- East India Pharmaceutical Works Ltd., Kolkata
- Nicholas Piramal India Ltd., Mumbai
- Santha Biotech, Hyderabad
- Zyphyr Biomedical, Goa
NUMBER OF SCIENTISTS OFFERED LECTURES AT VARIOUS UNIVERSITIES/ INSTITUTES
Invited Lectures … 25
Educational Lectures … 28 |
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