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Structural Biology & Bio-Informatics Division

Dr. Siddhartha Roy (Jr.)

Senior Scientist
Ph.D (2007) Indian Institute of Science, Bangalore, India
Post-doctoral Research Fellow (2008-2010) University of Colorado Denver, Aurora, USA
Post-doctoral Research Fellow (2010-2012) MD Anderson Cancer Center, Houston, USA


Contact -
roysiddhartha@iicb.res.in / roysid76@gmail.com

Current Research Interest

The focus of our laboratory is to unravelthe 3D- structures of proteins. We intend to explore the structure/function relationship and dynamicity of these macromolecules. We use X-ray crystallography, NMR and other biophysical and biochemical approaches to unravel these mysteries of nature.

  • Structural characterization of key epigenetics regulators.
  • Structure based design of inhibitor molecules against Malarial parasite.
  • Elucidation of RNA-Protein complexes at atomic resolution.
  • Structural investigation of Proteins involved in metabolic disorders in human.

Position Available: JRF

Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff
   

List of important Publications:

  1. Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong Z, Allen C, Siddhartha Roy, Nuñez JK, Nickoloff J, Kulesza CA, Yasui A, Côté J, Kutateladze TG.Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol. 2012; 19, 1266-1272.
  2. He J., Scott J.L.,Heroux A., Siddhartha Roy, Lenoir M., Overduin M., Stahelin R.V.,Kutateladze T.G.Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. J.Biol.Chem. 2011; 286(21); 18650-7.
  3. Lisandra E.W., *Siddhartha Roy, Weiner K.L., Hayashi R., Shi X., Appella E., Kutateladze T.G., Gozani O.The MBT repeats of L3MBTL1 link set8 mediated p53 methylation at lysine 382 to target gene repression. J.Biol.Chem. 2010; 285(48); 37725-32. (*Authors contributed equally to this work).
  4. Siddhartha Roy, Musselman C.A., Kachirskaia I., Hayashi R., Glass K., Nix J.C., Gozani O., Appella E., Kutateladze T.G.Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol. 2010; 398(4):489-96.
  5. Hom R.A., Chang P.Y., Siddhartha Roy, Musselman C.A., Glass K.C., Selezneva A.I., Gozani O., Ismagilov R.F., Cleary M.L. and Kutateladze T.G. Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain. J Mol Biol. 2010; 400(2):145-54.
  6. Siddhartha Roy, Saraswathi R., Sekar K., Chatterji D., and Vijayan M. Structural studies on the second Mycobacterium smegmatis Dps: invariant and variable features of structure, assembly and function.. J Mol Biol. 2008; 375(4):948-59.
  7. Kishore A.H., Vedamurthy B.M., Mantelingu K., Agrawal S., Reddy B.A., Siddhartha Roy, Rangappa K.S. and Kundu T.K. Specific small-molecule activator of Aurora kinase A induces autophosphorylation in a cell-free system. J Med Chem. 2008; 51(4):792-7.
  8. Mantelingu K., Reddy B.A, Swaminathan V., Kishore A.H., Siddappa N.B., Kumar G.V., Nagashankar G., Natesh N., Siddhartha Roy, Sadhale P.P., Ranga U., Narayana.C, and Kundu T.K. Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol. 2007; 14(6):645-57.
  9. Selvaraj M., Siddhartha Roy, Singh N.S., Sangeetha R., Varshney U. and Vijayan M. Structural plasticity and enzyme action: crystal structures of mycobacterium tuberculosis peptidyl-tRNA hydrolase. J Mol Biol. 2007; 372(1):186-93.
  10. Siddhartha Roy, Saraswathi R., Gupta S., Sekar K., Chatterji D. and Vijayan M. Role of N- and C-terminal tails in DNA binding and assembly in    Dps. Structural studies of Mycobacterium smegmatisDps deletion mutants. J Mol Biol. 2007; 370(4):752-67.
  11. Selvaraj M., Singh N.S., Siddhartha Roy, Sangeetha R., Varshney U. and Vijayan M. “Cloning, expression, purification, crystallization and preliminary X-ray analysis of PeptidyltRNA hydrolase from Mycobacterium tuberculosisActaCryst(2006). F62, 913-915.
  12. Sharma A, Thamotharon S., Siddhartha Roy and Vijayan M. “X-ray studies of crystalline complexes involving amino acids and peptides.XLI II.Adipic acid complexes of L- and DL-Lysine”. ActaCryst(2006).C62,o148-o152.
  13. Siddhartha Roy, Singh D.D., and Vijayan M. “X-ray studies on crystalline complexes involving amino acids and peptides.XLI. Adipic acid complexes of L-and DL-arginine and supramolecular association in arginine-dicarboxylic acid complexes”. ActaCryst(2005) B61, 89-95.
  14. Siddhartha Roy, Gupta S., Das S., Sekar K, Chatterji D. and Vijayan M. “X-ray analysis of Mycobacterium smegmatis Dps and a comparative study involving other Dps and Dps-like molecules”. J.Mol.Biol (2004) 339(5), 1103-1113.
  15. Saraswathi N.T., Siddhartha Roy and Vijayan M.X-ray studies on crystalline complexes involving amino acids and peptides.XLI. Commonalities in aggregation and conformation revealed by the crystal structures of the pimelic acid complexes of L-arginine and DL-lysine”. ActaCryst(2003) B59, 641-646.
  16. Siddhartha Roy, Gupta S., Das S., Sekar K., Chatterji D., and Vijayan M. “Crystallization and preliminary X-ray diffraction analysis of Mycobacterium smegmatisDps”. ActaCryst(2003) D59,2254-2256.

 

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Updated on 10th December 2012
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