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Structural Biology & Bio-Informatics Division

Dr. Subrata Adak

Senior Scientist
PhD, Jadavpur University, 1997
Fellow of American Heart Association, USA, 2000
Raman Research Fellow under CSIR, India, 2009-10
Contact - adaks@iicb.res.in

Current Research Interest

  • The biochemistry of metalloproteins in relation to structure-function relationship and molecular mechanism of catalysis.
  • Oxidative stress responses in Leishmania.
Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff
  1. Dr. Rina Shaha (SRA)
  2. Mr. Rajesh Yadav (SRF)
  3. Ms. Swati Pal (SRF)
  4. Ms. Moumita Bose (JRF)
  5. Mr. Supratim Mukerjee (JRF)
  6. Mr. Sumit Sen Santara (JRF)
  7. Ms. Jayasree Roy (PA)
 

List of important Publications:

  1. Pal, S., Dolai, S., Yadav, R.K. and Adak S. Ascorbate peroxidase from Leishmania major controls the virulence of infective stage of promastigotes by regulating oxidative stress (2010) PLoS ONE 5(6):e11271
  2. Yadav, R.K., Dolai, S., Pal, S. and Adak S.:Role of C-terminal acidic cluster in stabilization of heme spin state of ascorbate peroxidase from Leishmania major. (2010) Arch. Biochem. Biophys.495, 129–135.
  3. Dolai, S., Yadav, R.K., Pal, S. and Adak S.: Overexpression Of Mitochondrial Leishmania Major Ascorbate Peroxidase Shows Enhanced Tolerance To Oxidative Stress-Induced Programmed Cell Death And Protein Damage (2009) Eukaryot Cell 8, 1721–1731.
  4. Dolai, S., Yadav, R.K., Pal, S. and Adak S.:Leishmania major ascorbate peroxidase overexpression protects cells against reactive oxygen species-mediated cardiolipin oxidation (2008) Free Radic Biol Med. 45, 1520-1529.
  5. Yadav, R.K., Dolai, S., Pal, S. and Adak S.: Role of tryptophan-208 residue in cytochrome c oxidation by ascorbate peroxidase from Leishmania major-kinetic studies on Trp208Phe mutant and wild type enzyme. (2008) Biochim Biophys Acta. 1784, 863-871.
  6. Dolai, S., Yadav, R.K., Datta, A.K. andAdak, S.:Effect of Thiocyanate on the Peroxidase and Pseudocatalase Activities of Leishmania major Ascorbate Peroxidase. (2007) Biochim. Biophys. Acta 1770, 247-256.
  7. Adak S, and Datta A.K. (2005): Leishmania major encodes an unusual peroxidase that is a close homolog of plant ascorbate peroxidase: a novel role of the transmembrane domain. Biochem J. 390, 465-474.
  8. Stuehr, D.J., Santolini, J., Wang, Z.Q., Wei, C.C. and Adak, S. (2004): Update on Mechanism and Catalytic Regulation in the NO Synthases. J. Biol. Chem. 279, 36167-36170.
  9. Adak, S., Sharma, M., Meade, A. L., and Stuehr, D. J. (2002): A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity. Proc. Natl. Acad. Sci. U.S.A. 99, 13516 -13521
  10. Adak, S., Bilwes, A.M., Panda, K., Hosfield, D., Aulak, K.S., McDonald, J.F., Tainer, T.A., Getzoff, E.D., Crane, B.R., and Stuehr, D.J.: Cloning, expression, and characterization of a Nitric oxide synthase protein from Deinococcus radiodurans: (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 107-112.

Detail list of Publications upto December'2010 ==>> Click here

 

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Updated on 7th July'2010

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