Structural Biology & Bio-Informatics Division

Dr. Subrata Adak

PhD, Jadavpur University, 1997
Fellow of American Heart Association, USA, 2000
Raman Research Fellow under CSIR, India, 2009-10

Contact: adaks@iicb.res.in

Principal Scientist

Current Research Interest

  • The biochemistry of metalloproteins in relation to structure-function relationship and molecular mechanism of catalysis.
  • Oxidative stress responses in Leishmania.

Names of the group members including regular staff with designation and research fellows

Fellows / RA

Dr. Rina Shaha (SRA)
Mr. Sumit Sen Santara (SRF)
Ms. Jayasree Roy (PA)
Ms. Aditi Mukherjee (JRF)
Mr. Ayan Adhikari (JRF)

List of important Publications

  1. Saha, R., Bose, M., Santara, S. S., Roy, J. and Adak, S. Identification of proximal and distal axial ligands in Leishmania major pseudoperoxidase (2013) Biochemistry in press.
  2. Santara, S. S., Roy, J. Mukherjee, S., Bose, M., Saha, R., and Adak, S. Globin coupled heme containing oxygen sensor soluble adenylate cyclase in Leishmania prevents cell death during hypoxia (2013) Proc. Natl. Acad. Sci. U.S.A. 110, 16790–16795
  3. Adak, S. and Pal, S.: Ascorbate peroxidase acts as a novel determiner of redox homeostasis in Leishmania. (2013) Antioxid Redox Signal. 19, 746-754
  4. Saha, R., Bose, M., Santara, S. S., Roy, J. Yadav, R.K., and Adak, S. Effect of distal His mutation on the peroxynitrite reactivity of Leishmania major peroxidase (2013) Biochim. Biophys. Acta. 1834, 2057-2063
  5. Saha, R., Bose, M. and Adak, S. Mutation of Val90 to His in the pseudoperoxidase from Leishmania major enhances peroxidase activity (2013) Biochim. Biophys. Acta. 1834, 651-657
  6. Mukherjee, S., Santara, S. S., Das, S., Bose, M., Roy, J. and Adak, S. NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death. (2012) J. Biol. Chem. 287, 34992-35003
  7. Bose, M., Saha, R., Santara, S. S., Mukherjee, S., Roy, J. and Adak, S. Protection against peroxynitrite by pseudoperoxidase from Leishmania major. (2012) Free. Radic. Biol. Med. 53, 1819–1828
  8. Pal, S., Yadav, R.K. and Adak S.: Role of K+ binding residues in stabilization of heme spin state of Leishmania major peroxidase. (2012) Biochim. Biophys. Acta. 1824, 1002–1007
  9. Dolai, S., Pal, S., Yadav, R.K. and Adak S. Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism (2011) J. Biol. Chem. 286, 13638-13646
  10. Yadav, R.K., Pal, S., Dolai, S. and Adak S.: Role of proximal methionine residues in Leishmania major peroxidase. (2011) Arch. Biochem. Biophys. 515, 21–27. Cover page article.
 
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Updated on 05th December 2013


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