Molecular & Human Genetics Division

Dr. Suvendra Nath Bhattacharyya

PhD, Jadavpur University,Kolkata,West Bengal,India,2003

International Senior Research Fellow, The Wellcome trust London

2008-2012: Career Development Awardee of the International Human Frontier Science Program Organization

2004-2008: HFSPO Post-Doctoral Research Fellow at Friedrich Miescher Institute, Basel, Switzerland

2004: AAAS/Science-GE healthcare Young Scientist Award, USA and INSA Young Scientist award, INDIA

1998-2003: Research Fellow, Indian Institute of Chemical Biology, Calcutta, India

Contact: suvendra@iicb.res.in / suvendrab@yahoo.com


Principal Scientist

 

Current Research Interest

  • Effect of cellular microenvironment on miRNA-mediated gene regulation in mammalian cells.
  • Role of host cell miRNAs and other post-transcriptional factors in regulation of parasitic infection of mammalian cells
  • Mechanism of mRNA compartmentalization to translationally active polyribosomes and translationally inactive RNP-granules/P-bodies in mammalian cells.

Names of the group members including regular staff with designation and research fellows

Laboratory Members: (Post-Doctoral Fellow)

  1. Dr. Sudarshana Basu (RA, DBT)

Fellows / RA

  1. Mr. Anup Mazumder (SRF, CSIR)
  2. Mr. Souvik Ghosh (SRF, CSIR)
  3. Mrs. Kamalika Mukherjee (SRF)
  4. Ms. Bahnnisikha Barman (JRF, CSIR)
  5. Ms. Somi Patranabis (JRF, CSIR)
  6. Mr. Yogaditya Chakraborty (JRF, CSIR)
  7. Mr. Mainak Bose (SPM Fellow, CSIR)
  8. Ms. Bartika Ghosal (JRF, CSIR
  9. Mr. Avijit Goswami (JRF, CSIR)

List of important Publications

  1. Basu, S. and Bhattacharyya, S.N., (2014). Insulin-like growth factor-1 prevents miR-122 production in neighbouring cells to curtail its intercellular transfer to ensure proliferation of human hepatoma cells. Nucleic Acids Res., Advanced online publication 9th May 2014.
  2. Mazumder, A., Bose, M., Chakraborti, A., Chakrabarti, S. and Bhattacharyya, S.N., (2013). A transient reversal of miRNA-mediated repression controls macrophage activation. EMBO Rep., 14, 1008-1016.
  3. Ghosh, J., Bose, M., Roy, S., Bhattacharyya, S.N., (2013). Leishmania donovani Targets Dicer1to Downregulate miR-122, Lower Serum Cholesterol, and Facilitate Murine Liver Infection. Cell Host Microbe, 13, 277-288.
  4. Kundu, P., Fabian, M.R., Sonenberg, N., Bhattacharyya, S.N.*, Filipowicz, W*., (2012). HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Res., 40, 5088-6000.
  5. Cougot, N*., Bhattacharyya, S.N*., Tapia-Arancibia, L., Bordonné R., Filipowicz, W., Bertrand E., and Rage, F., (2008). Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation. J. Neuroscience, 28, 13793-13804.
  6. Filipowicz, W., Bhattacharyya, S.N., Sonenberg, N., (2008). Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet., 9, 102-114.
  7. Bhattacharyya, S.N., & Filipowicz W., (2007). Argonautes and company: sailing against the wind. Cell, 128, 1027-1028.
  8. Pillai, R.S., Bhattacharyya, S.N., & Filipowicz W., (2007). Repression of protein synthesis by miRNAs: How many mechanisms? Trends in Cell Biology, 17, 118-126.
  9. Bhattacharyya, S.N., Habermacher, R., Martine, U., Closs, E.I., & Filipowicz, W., (2006). Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell, 125, 1111-1124.
  10. Kotaja, N*., Bhattacharyya, S.N*., Jaskiewicz, L, Kimmins, S, Parvinen, M, Filipowicz, W., & Sassone-Corsi, P., (2006). The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc. Natl. Acad. Sci. U S A., 103, 2647-2652.
  11. Pillai, R.S., Bhattacharyya, S.N., Artus, C.G., Zoller, T., Cougot, N., Basyuk, E., Bertrand, E. & Filipowicz W., (2005). Inhibition of translational initiation by let-7 microRNA in human cells. Science, 309, 573-1576.
 
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Updated on 15th May 2014


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