Dr. Susanta Roychoudhury

Deputy Director, Scientist F
PhD, Calcutta University, 1985                                                                                      Visit lab page: Click Here.
Contact - susanta@iicb.res.in, susanta_rc@yahoo.co.in

Current Research Interest Genetic and epigenetic alterations of mismatch repair and spindle assembly checkpoint genes in oral cancer are being analysed to understand the molecular basis of genomic instability. The mechanism of spindle assembly checkpoint is being investigated to understand its role in aneuploidy. Systematic search for the single nucleotide polymorphisms in DNA repair genes is being carried out to identify the susceptibility alleles for the development of oral cancer. We are studying the association between cytokine and chemokine genes polymorphisms and Helicobacter pylori mediated gastroduodenal diseases. We are also performing the functional analysis of disease-associated polymorphisms to understand the biochemical basis of disease susceptibility.

Names of the group members including regular staff with designation and research fellows: Staff: Fellow/RA/PA Mr.Bhaskar Basu Technical, Group I(4) Ms. Dipanjana Datta De (SRF)                       Ms. Swati Bajaj (SRF)        Mr. Somsubhra Nath(SRF)                 Mr. Pinaki Mondal (SRF)                           Ms. Sumana Bhattacharjya(JRF) Ms. Tania Das (PA) Mr. Debrup Sen (JRF) Mr. Rajat Kumar Pal (PA) Mr. Arindam Datta (PA) Mr. Kayum Alam (JRF) Visit details about lab: Click here   List of important Publications: Chakrabarti, S., Dasgupta, S., Roy, S., Bhar, A., Sengupta, A., Roy, A., Ray, K., Bhattacharyya, N. P., Roy, B., Panda, C. K. and Roychoudhury, S. Microsatellite instability in squamous cell carcinoma of head and neck from the Indian patient population, Int. J. Cancer 92: 555-561 (2001) Basu, A., Mukherjee, N., Roy, S., Sengupta S., Banerjee S., Chakraborty M., Badal Dey, Roy M. Roy B., Bhattacharyya N. P., Roychoudhury S. and Majumder P. P. Ethnic India: A Genomic View, with Special Reference to Peopling and Structure. Genome Res. 13: 2277-2290 (2003) The Indian Genome Variation Consortium, The Indian Genome Variation database (IGVdb): a project overview, Hum Genet 118: 1-11 (2005) Mitra S., Sikdar N., Misra C., Gupta S., Paul R. R., Roy B., Panda C. K. and Roychoudhury S. Risk assessment of p53 genotypes and haplotypes in tobacco associated leukoplakia and oral cancer patients from eastern India. Int J Cancer 117: 786-793 (2005) Chakravorty M., Ghosh A., Choudhury A., Santra A., Hembrum J., Roychoudhury S. Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer. Human Mutation 27: 411-419 (2006) Mondal G., Sengupta S., Panda C. K., Gollin S.M., Saunders W. S. and Roychoudhury S. Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer. Carcinogenesis 28:81-92 (2007) Sengupta S., Chakrabarti S., Roy A., Panda C. K. and Roychoudhury S. Inactivation of hMLH1 and hMSH2 in HNSCC tumors and leukoplakia by promoter hypermethylation and its relation with MIN phenotype. Cancer 109:703-712 (2007) Chakravorty M., Datta De D., Choudhury A., and Roychoudhury S. IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int. J. Biochem. Cell Biol., 41:1502-1510 (2009) Banerjee T., Nath S. and Roychoudhury S. DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling. Nucleic Acids Res., 37:2688-2698 (2009) Misra C., Majumder M., Bajaj S., Ghosh S., Roy B. and Roychoudhury S. Polymorphisms at p53, p73 and MDM2 loci Modulate the risk of Tobacco Associated Leukoplakia and Oral Cancer. Mol Carcinogenesis Feb. 2009; DOI: 10.1002/mc.20523