Dr. Samir Kumar Dutta
Scientist E-II
Ph.D. (Pharm), Jadavpur University1986
Contact - samirkdutta@iicb.res.in / somir_india@yahoo.com
Current
Research Interest
The
basic concept is to convert knowledge-based science
achieved in this Lab to the technology of tomorrow.
The key to such concept relies on: -
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Identification and characterization of proteinaceous
amylase and/ or protease inhibitors from non-host
plant sources for the polyphagous-pest, Helicoverpa
armigera. Two protease inhibitor genes and
an amylase/ trypsin inhibitor gene have been
cloned recently (Sequences submitted to GenBank).
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Artificial feeding with these inhibitors proved
detrimental to armigera (Collaboration).
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Complete peas plant regenerated as a key to
incorporation and expression of the above
genes in peas/ chickpea through Agrobacterium.
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Potential of these inhibitors as tumoricidal,
MMP-inhibitor, t-PAI etc. is also under consideration.
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Protein Engineering (Synthesis of designer
proteins) is another aim of this Lab.
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of the group members including regular staff
with designation and research fellows: |
| Fellow/RA |
Fellow/RA |
Others |
- Dr.
Samir Kr Dutta, Sct-E-II
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- Mrs.
Sanhita Roy SRF, CSIR
- Ms.
Nilanjana Bhattacharjee SRF, UGC
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- Dr.
M. J. Mukhopadhyay, DST-WOS-A
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List of important Publications:
- Datta,
K., Usha, R., Dutta, S. K. and Singh,
M. (2001) A comparative study of the winged bean protease
inhibitors and their interaction with proteases. Plant
Physiol. Biochem. 39, 949-959.
- Dattagupta,
J. K., Podder, A., Chakrabarti C., Sen, U., Mukhopadhyay,
D., Dutta, S. K. and Singh, M. (1999)
Refined crystal structure (2.3 Å) of a double-headed
winged bean a-chymotrypsin inhibitor and location
of its second reactive site. Proteins: Structure,
Function, Genetics. 35 (3), 321-331.
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Hirabayashi, J., Dutta, S. K. and
Ken-ichi, K. (1998) Novel galactose-binding proteins
in Annelida; Characterization of 29 kDa Tandem repeat
type lectins from the Earthworm Lumbricus terrestris.
J. Biol. Chem. 273(23), 14450-14460.
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Dattagupta, J. K., Podder, A., Chakraborti, C., Sen,
U., Dutta, S. K. and Singh, M. (1996).
Structure of a Kunitz-type chymotrypsin inhibitor
from winged bean seeds at 2.95 Å resolution.
Acta. Crystallographica D 52, 521-528.
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