Dr. Tripti Dey

Senior Scientist
PhD, Calcutta University,1982

Current Research Interest

Glycoconjugates in Leishmanial Pathogenesis.
Role of CD1d-Restricted NKT Cells in Microbial Immunity using Visceral Leishmaniasis as the model.
Understanding of cell death induced by Glycan modified herbal products in Leishmania infected macrophages.
Glycan based vaccine against Visceral Leishmaniasis.

Names of the group members including regular staff with designation and research fellows:
	Fellow/RA
	Sibir Karmakar, SRF (CSIR) Majoj Singh, SRF (CSIR) Joydeep Paul, JRF (CSIR)

List of important Publications:

Karmakar S, Paul J, De T. (2011) Leishmania donovani glycosphimgolipid facilitates antigen presentation by inducing relocation of CD1d into lipid rafts in infected macrophages. Eur. J. Immunol (in press)
Choudhury R, Das P, De T, Chakraborti T. (2010) Immunolocalization and characterization of two novel proteases in Leishmania donovani: putative roles in host invasion and parasite development. Biochimie. 92(10) 1274-86.
Choudhury R, Das P, Bhaumik SK, De T, Chakraborti T. (2010) In situ immunolocalization and stage-dependent expression of a secretory serine protease in Leishmania donovani and its role as a vaccine candidate. Clin Vaccine Immunol. 17(4):660-7.
Bhaumik SK, Naskar K, De T. (2009) Complete protection against experimental visceral leishmaniasis with complete soluble antigen from attenuated Leishmania donovani promastigotes involves Th1-immunity and down-regulation of IL-10. Eur J Immunol. 39(8):2146-60.
Bhaumik SK, Singh MK, Karmakar S, De T. (2009) UDP-Gal: N-acetylglucosamine beta 1-4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis. Glycoconj J. 26(6):663-73.
Choudhury R, Bhaumik SK, De T, Chakraborti T. (2009) Identification, purification, and characterization of a secretory serine protease in an Indian strain of Leishmania donovani. Mol Cell Biochem. 320(1-2):1-14.
Bhaumik SK, Singh MK, Karmakar S, De T. (2008) Immuno stimulating glycophosphosphingolipid antigen from Leishmania donovani is recognized by visceral leishmaniasis patient sera. Mol Biochem Parasitol. 159(2):121-9.
Bhaumik SK, Singh M, Basu R, Bhaumik S, Roychoudhury K, Naskar K, Roy S, De T. (2008) Virulence attenuation of a UDP-galactose/N-acetylglucosamine beta1,4 galactosyltransferase expressing Leishmania donovani promastigote. Glycoconj J. 25(5):459-72.
Basu R, Bhaumik S, Haldar AK, Naskar K, De T, Dana SK, Walden P, Roy S. (2007) Hybrid cell vaccination resolves Leishmania donovani infection by eliciting a strong CD8+ cytotoxic T-lymphocyte response with concomitant suppression of interleukin-10 (IL-10) but not IL-4 or IL-13. Infect Immun. 75(12):5956-66.
Roychoudhury K, Dasgupta B, Sen P, Laskay T, Solbach W, De T, Roy S. (2006) Evidence of direct interactions between the CC-chemokines CCL3, CCL4 and CCL5 and Leishmania promastigotes. Mol Biochem Parasitol. 150(2):374-7.
Basu R, Bhaumik S, Mookherjee Basu J, Naskar K, De T and Roy S. (2005) Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial- sensitive and resistance strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-$ generation: Evidence for mixed Th1 and Th2- like response in visceral leishmaniasis. J. Immunol. 174(11):7160-71.

Detail list of Publications upto December'2010 ==>> Click here

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Updated on 21st February'2011