Dr. Rukhsana Chowdhury
Scientist E-1
PhD, Calcutta University,1989
Contact - rukhsana@iicb.res.in
Current
Research Interest
A
feature of the formidable adaptation strategy
of pathogenic microorganisms is the integration
of virulence gene expression with regulatory circuits
that respond to environmental and other conditions.
The objective of our group is to unravel the regulatory
circuitry that control virulence gene expression
in the enteric pathogen Vibrio cholerae. The following
aspects are being invetigated:
- Stress
response and regulation of virulence gene
expression. The response of V. cholerae
to physico-chemical stress parameters and
molecular mechanisms of the modulation of
virulence regulatory processes under these
conditions.
- Epigenetic
regulation of gene expression. Global
role of DNA methylation in gene expression.
- GASP
(Growth Advantage in the Stationary Phase)
mutants of V. cholerae and their virulence
properties.
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| Names
of the group members including regular staff
with designation and research fellows: |
| Fellow/RA |
Staff |
- Tanusree
Das RA (CSIR)
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Sanjib Banerjee SRF (CSIR)
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Arpita Chatterjee SRF (CSIR)
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Sohini Chaudhuri SRF (CSIR)
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Amalendu Ghosh SRF (CSIR)
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Abha Bhagat SRF (CSIR)
- Amit Kr Dey, SRF (ICMR)
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- Dr.
Kalidas Paul
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List
of important Publications:
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Ghosh,
A., K. Paul and R. Chowdhury 2006 Role of H-NS in
colonization, motility and bile dependent repression
of virulence gene expression in Vibrio cholerae.Infect.
Immun. (in press)
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Banerjee S., and R. Chowdhury. 2006 An orphan DNA
(cytosine-5-)-methyltransferase n Vibrio cholerae.
Microbiology (in press)
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Chatterjee, A., S. Chaudhuri, G. Saha, S. Gupta, and
R. Chowdhury. 2004 Effect of bile on the cell surface
permeability barrier and efflux system of Vibrio cholerae.
J. Bacteriol. 188: 6809-6814
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Paul,
K., A. Ghosh, N. Sengupta and R. Chowdhury. 2004 Competitive
growth advantage of non-toxigenic mutants in the stationary
phase in archival cultures of pathogenic Vibrio cholerae
strains.Infect. Immun. 72: 5478-5482
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Krishnan,
H. H., A. Ghosh, K. Paul and R. Chowdhury. 2004. Effect
of anaerobiosis on expression of virulence factors
in Vibrio cholerae.
Infect. Immun. 72: 3961-3967
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Sengupta
N., K. Paul and R. Chowdhury. 2003The global regulator
ArcA modulates expression of virulence factors in
Vibrio cholerae. Infect. Immun. 71: 5583-5589
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Chakrabarti
S., N. Sengupta and R. Chowdhury. 1999. Role of DnaK
in in vitro and in vivo expression of virulence factors
of Vibrio cholerae.
Infect. Immun. 67 : 1025 – 1033.
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Gupta S. and R. Chowdhury. Bile affects production
of virulence factors and motility of Vibrio cholerae.
Infect. Immun. 65 : 1131 – 1134.
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