Infectious Diseases & Immunology Division

Dr.Pijush Kanti Das

JC Bose National Fellow
PhD, FNA. FASc. FNASc. FAScT

Contact: pijushdas@iicb.res.in


Chief Scientist & Head

Interested in taking CSIR-NET student for Ph.D.

Current Research Interest

  • Macrophage biology in relation to disease pathogenesis using visceral leishmaniasis as  the model macrophage disease.
  • Comprehensive cyclic nucleotide signaling in the infectivity of a eukaryotic intracellular pathogen like Leishmania.
  • Immunomodulators of natural origin for effective therapy against macrophage-associated diseases.

 

Names of the group members including regular staff with designation and research fellows

Staff Member`s

Mr. Dipak Kr. Guin Sr. Steno.(ACP)
Ms. Arti Kheterpaul, Jr. Tech. Asst.

Research Fellows / RA

Ms. Arunima Biswas,SRF (CSIR)
E Mail : arunima10@gmail.com   
Mr. Gunjan Sharma,SRF (CSIR)
E Mail : candidgunjan@gmail.com
Mr. Writoban Basu Ball,SRF (CSIR)
E Mail : writoban@gmail.com
Ms. Supriya Srivastav, JRF (UGC)
E Mail : supriya114@gmail.com
Ms. M.adhuchhanda Mukherjee, JRF (CSIR)
E Mail : madhuchhanda.mukherjee@rediffmail.com
Ms. Shreyasi Palit, JRF (UGC)
E Mail : mail2shreyasi@gmail.com 
Mr. Amit Vij, JRF (CSIR)
E Mail : amitvij1885@yahoo.com

List of important Publications

  1. Ghosh, K., Sharma, G., Saha, A., Kar, S., Das, P.K. and Ukil, A. (2012) Successful Therapy of Visceral Leishmaniasis with Curdlan Involves Th17 Cytokines. J. Infect. Dis. [Epub ahead of print].
  2. Srivastav, S., Kar, S., Chande, A.G., Mukhopadhyaya, R. and Das, P.K. (2012) Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response. J. Immunol. 189,924-934
  3. Kar, S., Palit, S., Basu Ball, W. and Das, P.K. (2012) Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis, 17, 735-747.
  4. Sharma, G., Kar, S., Palit, S. and Das, P.K. (2012) 18β-Glycyrrhetinic acid (Concur) induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. J. Cell Physiol. 227, 1923-1931.
  5. Bhattacharya, A., Biswas, A. and Das, P.K. (2012) Identification of a protein kinase A regulatory subunit from Leishmania having importance in metacyclogenesis through induction of autophagy. Mol. Microbiol. 83, 548-564.
  6. Ukil, A., Kar, S., Srivastav, S. and Das, P.K. (2011) Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases. PLoS ONE, 6, e29062.
  7. Basu Ball, W., Kar, S., Mukherjee, M., Chande, A.G., Mukhopadhyaya, R. and Das, P.K. (2011) Uncoupling protein 2 negatively regulates reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis. J. Immunol. 187, 1322-1332.
  8. Biswas, A., Bhattacharya, A. and Das, P.K. (2011) Role of cAMP signaling in the survival and infectivity of the protozoan parasite, Leishmania donovani. Mol. Biol. Int. 2011, Article ID 782971, 9 pages.
  9. Biswas, A., Bhattacharya, A., Kar, S. and Das, P.K. (2011) Expression of IL-10-triggered STAT3-dependent IL-4Ra is required for induction of arginase 1 in visceral leishmaniasis. Eur. J. Immunol. 41, 992-1003.
  10. Kar, S., Sharma, G. and Das, P.K. (2011) Fucoidan cures infection against both antimony-susceptible and –resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants. J. Antimicrob. Chemother. 66, 618-625.
  11. Kar, S., Ukil, A. and Das, P.K. (2011) Cystatin cures visceral leishmaniasis by NF-kB-mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tp12-ERK pathway. Eur. J. Immunol. 41, 116-127.
  12. Kar, S., Ukil, A., Sharma, G. and Das, P.K. (2010) MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. J. Leukocyte Biol. 88, 9-20.
  13. Bhattacharya, A., Biswas, A. and Das, P.K. (2009) Role of a differentially expressed cAMP phosphodiesterase in regulating the induction of resistance against oxidative damage in Leishmania donovani. Free Radical Biol. Med. 47, 1494-1506.
  14. Kar, S., Ukil, A. and Das, P.K. (2009)  Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kB and JAK/STAT pathways. Eur. J. Immunol. 39, 741-751.
  15. Bhattacharya, A., Biswas, A. and Das, P.K. (2008)  Role of intracellular cAMP in differentiation-coupled induction of resistance against oxidative damage in Leishmania donovani. Free Radical Biol. Med. 44, 779-794.
  16. Mukherjee, S., Ukil, A. and Das, P.K. (2007)    Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, using leishmaniasis as model macrophage disease. Antimicrob. Agents Chemother. 51, 1700-1707.
  17. Karmakar, S., Ukil, A., Mukherjee, S. and Das, P.K. (2006). Regulation of guanylyl cyclase by intracellular Ca+2 in relation to the infectivity of the protozoan parasite, Leishmania donovani. Int. J. Biochem. Cell Biol. 38, 1277-1289.
  18. Ukil, A., Maity, S. and Das, P.K. (2006). Protection of experimental colitis by theaflavin-3,3¢-digallate correlates with inhibition of IKK and NF-kB activation.  Brit. J. Pharmacol. 149, 121-131.
  19. Ukil, A., Biswas, A., Das, T. and Das, P.K. (2005). 18b-Glycyrrhetinic acid triggers curative Th1 response and NO upregulation in experimental visceral leishmaniasis associated with the activation of NF-kB.  J. Immunol. 175, 1161-1169.
  20. Mukherjee, S., Das, L., Kole, L., Karmakar S., Datta, N., & Das, P.K. (2004). Targeting of parasite-specific immunoliposome-encapsulated doxorubicin in the treatment of experimental visceral leishmaniasis. J. Infect. Dis. 189, 1024-1034.
  21. Karmakar, S., Bandyopadhyay, K., Biswas, A. and Das, P.K. (2003). Membrane orientation of laminin binding protein: An extracellular matrix bridging molecule of Leishmania donovani. Eur. J. Biochem. 270, 1-8.
  22. Datta, N., Mukherjee, S., Das, L. & Das, P.K. (2003). Targeting of immunostimulatory DNA cures experimental visceral leishmaniasis through nitric oxide up-regulation and T cell activation. Eur. J. Immunol. 33, 1508-1518.
 
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Updated on 29th January 2013


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