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Infectious Diseases & Immunology Division

Dr.Pijush Kanti Das (Head)

Chief Scientist
JC Bose National Fellow
PhD, FNA. FASc. FNASc. FAScT

Contact - pijushdas@iicb.res.in

Interested in taking CSIR-NET student for Ph.D.

Current Research Interest

  • Macrophage biology in relation to disease pathogenesis using visceral leishmaniasis as  the model macrophage disease.
  • Comprehensive cyclic nucleotide signaling in the infectivity of a eukaryotic intracellular pathogen like Leishmania.
  • Immunomodulators of natural origin for effective therapy against macrophage-associated diseases
Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff
  1. Ms. Arunima Biswas,SRF (CSIR), E Mail : arunima10@gmail.com   
  2. Mr. Gunjan Sharma,SRF (CSIR), E Mail : candidgunjan@gmail.com
  3. Mr. Writoban Basu Ball,SRF (CSIR), E Mail : writoban@gmail.com
  4. Ms. Supriya Srivastav, JRF (UGC), E Mail : supriya114@gmail.com
  5. Ms. M.adhuchhanda Mukherjee, JRF (CSIR), E Mail : madhuchhanda.mukherjee@rediffmail.com  
  6. Ms. Shreyasi Palit, JRF (UGC), E Mail : mail2shreyasi@gmail.com 
  7. Mr. Amit Vij, JRF (CSIR), E Mail : amitvij1885@yahoo.com
  1. Mr. Dipak Kr. Guin, Sr. Steno.(ACP)
  2. Ms. Arti Kheterpaul, Jr. Tech. Asst.

List of recent Publications:

  1. Ghosh, K., Sharma, G., Saha, A., Kar, S., Das, P.K. and Ukil, A. (2012) Successful Therapy of Visceral Leishmaniasis with Curdlan Involves Th17 Cytokines. J. Infect. Dis. [Epub ahead of print].
  2. Srivastav, S., Kar, S., Chande, A.G., Mukhopadhyaya, R. and Das, P.K. (2012) Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response. J. Immunol. 189,924-934
  3. Kar, S., Palit, S., Basu Ball, W. and Das, P.K. (2012) Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis, 17, 735-747.
  4. Sharma, G., Kar, S., Palit, S. and Das, P.K. (2012) 18β-Glycyrrhetinic acid (Concur) induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. J. Cell Physiol. 227, 1923-1931.
  5. Bhattacharya, A., Biswas, A. and Das, P.K. (2012) Identification of a protein kinase A regulatory subunit from Leishmania having importance in metacyclogenesis through induction of autophagy. Mol. Microbiol. 83, 548-564.
  6. Ukil, A., Kar, S., Srivastav, S. and Das, P.K. (2011) Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases. PLoS ONE, 6, e29062.
  7. Basu Ball, W., Kar, S., Mukherjee, M., Chande, A.G., Mukhopadhyaya, R. and Das, P.K. (2011) Uncoupling protein 2 negatively regulates reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis. J. Immunol. 187, 1322-1332.
  8. Biswas, A., Bhattacharya, A. and Das, P.K. (2011) Role of cAMP signaling in the survival and infectivity of the protozoan parasite, Leishmania donovani. Mol. Biol. Int. 2011, Article ID 782971, 9 pages.
  9. Biswas, A., Bhattacharya, A., Kar, S. and Das, P.K. (2011) Expression of IL-10-triggered STAT3-dependent IL-4Ra is required for induction of arginase 1 in visceral leishmaniasis. Eur. J. Immunol. 41, 992-1003.
  10. Kar, S., Sharma, G. and Das, P.K. (2011) Fucoidan cures infection against both antimony-susceptible and –resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants. J. Antimicrob. Chemother. 66, 618-625.
  11. Kar, S., Ukil, A. and Das, P.K. (2011) Cystatin cures visceral leishmaniasis by NF-kB-mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tp12-ERK pathway. Eur. J. Immunol. 41, 116-127.
  12. Kar, S., Ukil, A., Sharma, G. and Das, P.K. (2010) MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. J. Leukocyte Biol. 88, 9-20.
  13. Bhattacharya, A., Biswas, A. and Das, P.K. (2009) Role of a differentially expressed cAMP phosphodiesterase in regulating the induction of resistance against oxidative damage in Leishmania donovani. Free Radical Biol. Med. 47, 1494-1506.
  14. Kar, S., Ukil, A. and Das, P.K. (2009)  Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kB and JAK/STAT pathways. Eur. J. Immunol. 39, 741-751.
  15. Bhattacharya, A., Biswas, A. and Das, P.K. (2008)  Role of intracellular cAMP in differentiation-coupled induction of resistance against oxidative damage in Leishmania donovani. Free Radical Biol. Med. 44, 779-794.
  16. Mukherjee, S., Ukil, A. and Das, P.K. (2007)    Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, using leishmaniasis as model macrophage disease. Antimicrob. Agents Chemother. 51, 1700-1707.
  17. Karmakar, S., Ukil, A., Mukherjee, S. and Das, P.K. (2006). Regulation of guanylyl cyclase by intracellular Ca+2 in relation to the infectivity of the protozoan parasite, Leishmania donovani. Int. J. Biochem. Cell Biol. 38, 1277-1289.
  18. Ukil, A., Maity, S. and Das, P.K. (2006). Protection of experimental colitis by theaflavin-3,3¢-digallate correlates with inhibition of IKK and NF-kB activation.  Brit. J. Pharmacol. 149, 121-131.
  19. Ukil, A., Biswas, A., Das, T. and Das, P.K. (2005). 18b-Glycyrrhetinic acid triggers curative Th1 response and NO upregulation in experimental visceral leishmaniasis associated with the activation of NF-kB.  J. Immunol. 175, 1161-1169.
  20. Mukherjee, S., Das, L., Kole, L., Karmakar S., Datta, N., & Das, P.K. (2004). Targeting of parasite-specific immunoliposome-encapsulated doxorubicin in the treatment of experimental visceral leishmaniasis. J. Infect. Dis. 189, 1024-1034.
  21. Karmakar, S., Bandyopadhyay, K., Biswas, A. and Das, P.K. (2003). Membrane orientation of laminin binding protein: An extracellular matrix bridging molecule of Leishmania donovani. Eur. J. Biochem. 270, 1-8.
  22. Datta, N., Mukherjee, S., Das, L. & Das, P.K. (2003). Targeting of immunostimulatory DNA cures experimental visceral leishmaniasis through nitric oxide up-regulation and T cell activation. Eur. J. Immunol. 33, 1508-1518.

Detail list of Publications upto May'2012 ==>> Click here

 
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Updated on 29th January'2013
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