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Immunology Division

Dr. C. Mandal

Scientist G
PhD, F.N.A.,F.A.Sc,F.N.A.Sc.
Contact - cmandal@iicb.res.in

Current Research Interest

Main theme of our group is to understand the mystery of glycosylation of biomolecules modified specifically in patients with leukemia and visceral leishmaniasis and their potential applications in medical research.

The following aspects are being investigated:

  • Exploration of modified sialoglyconjugates induced on immune cells and plasma/ sera of both host and parasites
  • Proteomics of these purified clinically important molecules to identify host protective molecules
  • Development of antigen based diagnostic tool and their biological role in Visceral leishmaniasis (VL).
  • Investigation of O-acetylated sialoglycotopes in childhood acute lymphoblastic leukemia (ALL) and the role of the disease-specific antigen and antibodies in understanding the disease-biology.
  • Role of glycosylation mainly differential sialylation in adhesion process and cell signaling of hematopiotic stem cell for their potential application in childhood ALL.
  • Programmed cell death of cancer cell and signaling
  • Understanding of glycosylated molecular variants of human C-reactive proteins, an innate immune component, in relation to different pathological conditions
Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff
  1. Dr. Chandan Mandal (Research Associate)
  2. Dr. Waliza Answar (Research Associate)
  3. Mr. Sajal Samanta (SRF)
  4. Mr. Biswajit Khatua (JRF)
  5. Mr. Anjan Talukder (JRF)
  6. Ms. Ranjita Das (JRF)
  1. Mr. Asish Mallick (Technical Officer)
  2. Mrs. Rita Maity (project assistant)
  3. Mr. Saptrashi Roy (Project Assistant level 2)
  4. Mr. Kaushik Bhattacharya (Project Assistant level 2)
  5. Mr. Suman Kumar Samanta (Project Assistant level 2)
  6. Mr. Sayantani Sarkar (Project Assistant level 2)
  7. Mr. Arup Kumar Bag (Project Assistant level 2)

List of important Publications:

  1. Angana Ghoshal, Gerrit J. Gerwig, Johannis P. Kamerling, and Chitra Mandal (2010) Sialic acids in different Leishmania spp., its correlation with nitric oxide resistance and host responses.  Glycobiology  (accepted)
  2. Kaushik Bhattacharya, Suman K. Samanta, Rakshamani Tripathi, Asish Mallick, Sarmila Chandra, Bikas C. Pal, Chandrima Shaha and Chitra Mandal (2010) Apoptotic effects of mahanine on human leukemic cells are mediated through cross talking between Apo-1/Fas signaling with Bid protein and via mitochondrial pathways. Biochemical Pharmacology 79: 361-72.
  3. Chandan mandal, Cristina Tringali, Susmita Mondal, Leugi Anastasia, Sarmila Chandra, Venerando Burno and Chitra Mandal (2010) Down-regulation of membrane-bound Neu3 is negatively correlated with disease progression and associated with apoptosis suppression of lymphoblasts in childhood acute lymphoblastic leukemia. International J Cancer 126:337-349
  4. Jain R, Ghoshal A, Mandal Chitra, Shaha C. (2009) Leishmania cell surface prohibitin: role in host-parasite interaction. Cell Microbiol. Nov 2. [Epub ahead of print]  PMID: 19888987
  5. Khatua B, Ghoshal A, Bhattacharya K, Mandal C, Saha B, Crocker PR, Mandal Chitra. (2009). Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition.  FEBS Lett. Nov 27. [Epub ahead of print] PMID: 19945458
  6. Susmita Mondal, Chandan Mandal, Sarmila Chandra and Chitra Mandal (2009) Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia. Leukemia Research     Aug 24. [Epub ahead of print] PMID: 19709745
  7. Rajdeep Chowdhury, Suchandra Chowdhury, Paromita Roychoudhury, Chitra Mandal and Keya Chaudhuri (2009) Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation. Apoptosis 14, 108-123
  8. Aparajita Pal, Iman Bhattacharya, Kaushik Bhattacharyya, Chitra Mandal, Manju Ray (2009) Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in Sarcoma-180 bearing mice: Involvement of MAP kinase, NF kb signal transduction pathway. Molecular Immunology 46, 2039-44
  9. Angana Ghoshal, Sumi Mukhopadhyay, Rodion Demine, Michael Forgber, Saulius Jarmalavicius, Bibhuti Saha, Shyam Sundar, Peter Walden, Chhabinath Mandal, and Chitra Mandal (2009) Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis. Glyconjugate Journal 26, 675-89.
  10. Waliza Ansar, Sumi Mukhopadhyay, Shyamasree Basu, SK. Hasan Habib, Bibhuti Saha, Asish Kumar Sen, Chhabinath Mandal, and Chitra Mandal (2009) Disease-associated glycosylated moleclar variants of human C-reactive protein activate complement-mediated hemolysis of erythrocytes in tuberculosis and Indian Visceral leishmaniasis. Glycoconjugate J 26, 1151
  11. Chandan Mandal, G. Vinayaga Srinivasan, Suchandra Chowdhury, Sarmila Chandra, Chhabinath Mandal, Roland Schauer, and Chitra Mandal (2009) High Level of Sialate-O-acetyltransferase Activity in Lymphoblasts of Childhood Acute Lymphoblastic Leukaemia (ALL): Enzyme Characterization and Correlation with Disease Status. Glycoconjugate Journal 26, 57-73
  12. Waliza Ansar, SK. Hasan Habib, Samir Roy, Chhabinath Mandal and Chitra Mandal (2009). Unraveling the C-reactive protein complement-cascade in destruction of red blood cells: Potential Pathological Implications In Plasmodium falciparum Malaria. Cellular physiol biochem 23, 175-190
  13. Kankana Mukherjee, Anil  K  Chava, Suman  Bandyopadhyay, Asish  Mallick, MSc; Sarmila Chandra, Chitra mandal (2009). Co-expression of 9-O-acetylated sialoglycoproteins and their binding proteins on lymphoblasts of childhood acute lymphoblastic leukaemia: an anti-apoptotic role. Biol Chemistry 2009 390, 325-335
  14. Angana Ghoshal, Sumi Mukhopadhyay, Bibhuti saha, and Chitra Mandal (2009) 9-O-acetylated sialoglycoproteins: Important immunomodulators in Indian visceral leishmaniasis, Clinical and Vaccine Immunology 18, 889-898
  15. Sambuddha Banerjee, Susmita Mondal, Soma Sen, Saurabh Das, David L. Hughes, Corrado Rizzoli, Cédric Desplanches, Chitra Mandal and Samiran Mitra (2009) Four New Dinuclear Cu(II) Hydrazone Complexes Using Various Organic Spacers: Syntheses, Crystal Structures, DNA Binding and Cleavage Studies and Selective Cell Inhibitory Effect Towards Leukemic and Normal Lymphocytes.  Dalton Trans, 4:6849-60.
  16. Chandan Mandal, Avijit Dutta, Asish Mallick, Sarmila Chandra, Laxminarain Misra, Rajender  Sangwan, and Chitra Mandal (2008) Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin in a transcription-dependent manner through mitochondrial death cascade.  Apoptosis. 13, 1450-1464
  17. Kankana Mukherjee, Anil Kumar Chava, Chandan Mandal, Sailendra Nath Dey, Bernhard Kniep, Sarmila Chandra, Chitra Mandal (2008) O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia. J. Cell biochem, 2008 105, 724-34
  18. Suchandra Chowdhury, Suman Bandyopadhyay, Chandan Mandal, and Sharmila Chandra, and Chitra Mandal  (2008) Flow-cytometric monitoring of disease-associated expression of 9-0 acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal fllow-up study BMC Cancer, 8, 40
  19. Angana Ghoshal, Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal (2008) sialoglycotherapeutics in protozoal diseases Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers, 8, 358-369
  20. Avijit Dutta, Debjani Sarkar, Ameenah Gurib-Fakim, Chitra Mandal* and Mitali Chatterjee (2008) In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis. Parasitol Res 102, 1235-42
  21. Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal (2008) Targeting glycoproteins or glycolipids and their metabolic pathways for anti-parasite therapy, Review, Advances in Experimental Medicine and Biology   625: 87-102.

 

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Updated on 6th September''2010

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