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Drug Development Diagnostics & Biotechnology Division

Dr (Mrs) Suman Khowala

Sr. Principal Scientist & Head
PhD(Biochemistry), University of Calcutta, 1986
Contact: sumankhowala@iicb.res.in / sumankhowala@yahoo.com

Current Research Interest

  • Biotechnology for utilization of cellulose/hemicellulose and biomass as renewable source of energy.
  • Biotechnology for bio-sorption and bio-degradation of toxic pollutants in tannery fluids and wastes.
  • Role of glycosylation on synthesis, activity and secretion of glycosidases in T. clypeatus.
  • Aggregation of sucrase with enzymes produced by the fungus in relation to stability, activity and extracellular release of the proteins in Termitomyces clypeatus.
  • Study of protein-protein interaction (Molecular chaperone like properties of sucrase)
Names of the group members including regular staff with designation and research fellows:
Staff: Fellow/RA
 

Present:

  1. Dr. Swagata Pal , Email: sp2_77@gmail.com
  2. Dr.Debopam Banerjee, Email: debopambanerjee@yahoo.co.in
  3. Dr.Arijit Mondal
  4. Mrs.Soumya Mukherjee, Email: somymuk@ gmail.com
  5. Mr.Rajib Majumder, Email: majumder.rajib2008@ gmail.com
  6. Ms.Sanzeeta Tamang, Email: sanjeeta.tamang@yahoo.in
  7. Mr.Siddhartha Mukherjee, Email: siddharthamukherjee1@ gmail.com
 

Past:

  1. Dr. Sumana Mukherjee
  2. Dr.Sudeshna Chaudhuri, Email: Sudeshna3@gmail.com
  3. Dr. Shakuntala Ghorai , Email: shakuntalaghorai@yahoo.co.in
  4. Dr. Samudra Prosad Banik, Email: samudrapb@gmail.com
  5. Dr. Lata Ramrakhiani, Email: lata_ram@hotmail.com

List of important Publications:

  1. Shakuntala Ghorai, Sudeshna Chowdhury, Swagata Pal, Samudra Prosad Banik, Sumana Mukherjee, Suman Khowala (2010) Enhanced activity and stability of cellobiase (b-glucosidase: EC 3.2.1.21) produced in the presence of 2-deoxy-D-glucose from the fungus Termitomyces clypeatus; Carbohydrate Research, 345,1015–1022.http://dx.doi:10.1016/j.carres.2010.02.021
  2. S. Pal, S. Ghorai, S. Chowdhury, S. P. Banik and Suman Khowala (2010) Purification and characterization of a thermostable intracellular beta-glucosidase with transglycosylation properties from filamentous fungus Termitomyces clypeatus; Bioresource Technology 101, 2412–2420. http://dx.doi:10.1016/j.biortech.2009.11.064
  3. Sudeshna Chowdhury, Shakuntala Ghorai, Samudra Prosad Banik, Swagata Pal, Soumen Basak, Suman Khowala, (2009) Characterization of a novel low molecular weight sucrase from filamentous fungus Termitomyces clypeatus Process Biochemistry. 44, 1075–1082. http://dx.doi.org/10.1016/j.procbio.2009.05.009
  4. Ghorai, S., Banik S. P., Verma, D, Chowdhury S, Mukherjee S. and Suman Khowala (2009) Fungal Biotechnology in food and feed processing, Food Research International, 42, 577-587. http://dx.doi.org/10.1016/j.foodres.2009.02.019
  5. Samudra P Banik, S. Pal, S. Ghorai, S. Chowdhury and Suman Khowala. (2009) Interference of Sugars in the Coomassie Blue G Dye Binding Assay of Proteins, Analytical Biochemistry, 386, 113-115.
  6. Sumana Mukherjee, S. Chowdhury, S.Ghorai, S. Pal and Suman Khowala. (2006) Cellobiase from Termitomyces clypeatus: Activity and secretion in presence of glycosylation inhibitors, Biotechnology Letters, 28, 1773-1778. http://dx.doi.org/10.1007/s10529-006-9150-3
  7. S. Mukherjee and Suman Khowala. (2002) Secretion of cellobiase is mediated via vacuoles in Termitomyces clypeatus, Biotechnology Progress, 18, 1195-1200.
  8. S. Mukherjee, S. Basak and Suman Khowala. (2002) Regulation (Alteration) of activity and conformation of sucrase on co-aggregation with cellobiase in culture medium of Termitomyces clypeatus, Biotechnology Progress. 18, 404-408.
  9. S. Mukherjee and Suman Khowala. (2002) Regulation of cellobiase secretion in Termitomyces clypeatus by co-aggregation with sucrase. Current Microbiology. 45, 70-73.
  10. S. Mukherjee, S. Basak and Suman Khowala. (2001) Hetero-aggregation with sucrase affects the activity, stability and conformation of extra and intra-cellular cellobiase in the filamentous fungus Termitomyces clypeatus. Enzyme & Microbial Technology. 29, 213-224.
  11. S. Bhattacharya, Suman Khowala, A. Kumar and S. Sengupta. (1997), Purification and characterization of β-xylosidase from Termitomyces clypeatus. Biotechnology Progress. 13, 322-327.
  12. Suman Khowala, A. K. Ghosh and S. Sengupta. (1992) Saccharification of xylan by an amyloglucosidase of Termitomyces clypeatus and synergism in presence of xylanase. Applied Microbiology & Biotechnology. 37, 287-292.
  13. Suman Khowala and S. Sengupta. (1992) Secretion of b-glucosidase by Termitomyces clypeatus- Regulation by carbon catabolite product(s). Enzyme and Microbiol Technology. 14, 144-149.
  14. Suman Khowala, P. K. Goswami, A. K. Naskar, M. L. Jana and S. Sengupta. (1990) Selective susceptibility of o- (Carboxymethyl) starch to amyloglucosidase activity. Carbohydrate Research. 203, 265-270.
  15. Suman Khowala, M. Mukherjee and S. Sengupta. (1988) o-(Carboxymethyl) xylan a specific substrate directly hydrolysing and side chain reaching b-D (1® 4) xylanases. Enzyme & Microbiol Technology. 10, 563-567.
    • S. Sengupta, Suman Khowala and P .K. Goswami. (1987) Assay of endo-b-D-xylanase activity with a soluble o- (Carboxymethyl) derivative of larch wood xylan. Carbohydrate Research. 168, 156-161.
    • Suman Khowala and S. Sengupta. (1985) Purification and properties of an endo-alpha-mannan hydrolase from the mushroom Volvariella volvacea. Archives of Biochemistry & Biophysics. 242, 533-539.

Book chapters:

  1. Deepak Verma, Rajib Majumder, Soumya Mukherjee, Suman Khowala, (2009) Termitomyces: a nutritive alternative for food and food bioproducts, in Current Topics on Bioprocesses in Food Industry, eds. Professor LV Rao, Professor Christian Larroche, Professor Ashok Pandey, Asiatech Publishers, Inc. New Delhi, pp 118-129.
  2. Swagata Pal, Baishali Guha, Arpita Maity, Shakuntala Ghorai, Suman Khowala, 2010, Microbial production of food enzyme, In the book Food Biotechnology eds. A. Pandey, C. Larroche, C. R. Soccol, Asiatech Publishers Inc. New Delhi, pp 582-617.
  3. Khowala S., Verma D. & Banik S. P. (2008) chapter on "Carbohydrates" in an e-book "Biomolecules - Introduction, Structure and Function" at National Science Digital Library (NSDL). [http://nsdl.niscair.res.in/handle/123456789/802]  

Patents:

US patent 6946277, (2005) Method for enhancing cellobiase activity of Termitomyces clypeatus using a glycosylation inhibitor,

Patent no. 2649 DEL2008, (2008) A low molecular weight polypeptide with hydrolyzing activity on beta-D-fructofuransyl-alpha-D-glucopyranoside.

Fellow:

Indian Chemical society
International Society of Biotechnology

Memberships of Societies:

Society of Biological Chemists (I)
Indian Science Congress Association
Association for Carbohydrate Chemists & technologists
Indian Society of Cell Biology
Indian Chemical Society
The Biotech Research Society, India
Executive member of Society of Biological Chemists (I), Kolkata Chapter
Secretary, The Biotech Research Society, India, Kolkata (IICB-JU Chapter)

Detail list of Publications upto December'2010 ==>> Click here

 

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Uploaded on 24th January'2011

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