Dr. Snehasikta Swarnakar
Scientist E
PhD, Jadavpur University,1994
Post Doc.,[1994 - 97] - University of California, Davis and Marine Biological Laboratory, Woods Hole
Research Scientist (SUNY @ Stony Brook, 1997-01)
Visiting Scientist (TSRI, San Diego, 2002 and UConn, USA,2007),National Bioscience Award (2007)
Contact: sikta@iicb.res.in
Current Research Interest
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Role of matrix metalloproteinases (MMPs) in gastric ulcers induced by stress, alcohol, non-steroidal anti-inflammatory drug and infection by Helicobacter pylori. To study the effect of potential mediators like cytokines, growth factors and transcription factors for infectivity by H. pylori.
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Ploymorphism in the promoter regions of MMPs and risk of gastric cancers.
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Biochemical mechanism of gastric inflammation and its healing by bioactive lead molecule in regard to MMPs regulation. Effect of curcumin and melatonin in angiogenesis, collagen synthesis and apoptosis during wound healing.
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Role of MMPs, growth factors, receptors and cell adhesion molecules in gastric cancer, alcohol-induced liver damage, diabetes and endometriosis.
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| Names of the group members including regular staff with designation and research fellows: |
| Fellow/RA |
Others |
- Dr. Susri Ray Chaudhuri (RA)
- Sumit Pal (SRF)
- Laishram Pradeepkumar Singh (SRF)
- Amartya Mishra (SRF)
- Sanjib Dey (SRF)
- Arijit Ghosh (JRF)
- Kuntal Goswami (JRF)
- Poulami Khan (JRF)
- Kousik Kesh (JRF)
- S. Stalin (JRF)
Click for e-mail ID |
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List of important Publications:
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Ganguly, K and Swarnakar, S. Induction of MMP-9 and-3 in non steroidal anti-inflammatory drug induced acute gastric ulces in mice: Regulation by melatonin. J. Pineal Research, (2009) (in press)
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De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A, Nair GB, Mukhopadhyay AK. Antimicrobial activity of curcumin against Indian Helicobacter pylori and also during mice infection. Anti Agents Chemo, (2009) 53(4):1592-1597.
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Paul, S., Sharma, A.V., DasMahapatra, P., Bhattacharya, P. and Swarnakar, S. Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis J. Pineal Res. (2008) 44, 439-449.
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Swarnakar, S., Mishra, A., Ganguly, K. and Sharma, A. V. Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice. J. Pineal Research. (2007) 43,56-64.
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Singh, L. P., Kundu, P., Ganguly, K., Mishra, A and Swarnakar, S. A novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. Free Rad. Biol. Med. (2007) 43, 289-299.
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Kundu, P., Mukhopadhyay, K A., Patra, J., Banerjee, A., Berg, D.E. and Swarnakar, S. Cag negative Helicobacter pylori strain infection upregulates matrix metalloproteinase-9 expression and activity in mice. J. Biol. Chem. (2006) 281, 34651-34662.
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Ganguly, K., Kundu, P., Banerjee, A., Reiter, R.J. and Swarnakar, S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Rad. Biol. Med. (2006) 41, 911-925.
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Ganguly, K., Maity, P., Reiter R.J. and Swarnakar, S. Effect of melatonin on secreted and induced matrix metalloproteinases-9 and-2 activity during prevention of indomethacin induced gastric ulcer. J. Pineal. Res. (2005) 39, 305-314.
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Swarnakar, S., Ganguly, K., Kundu, P., Banerjee, A., Maity, P. and Sharma, A.V. Curcumin regulates expression and activity of matrix metalloproteinases -9 and -2 during prevention and healing of indomethacin- induced gastric ulcer. J. Biol. Chem. (2005) 280, 9409-15.
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Swarnakar, S., Temel, R. E., Connelly, M. A., Azhar, S. and Williams, W. L. Scavenger receptor, class B, Type I mediates selective uptake of low density lipoprotein cholesteryl ester. J. Biol. Chem. (1999) 274, 29733-39.
Significant review article:
- Vidavalur, R., Swarnakar, S. Thirunavukkarasu, M., Samuel, S M and Maulik, N. In vivo and in vitro approaches to study mechanisms of cardioprotection targeting Ischemia/Reperfusion (I/R) injury: useful technique for cardiovascular drug discovery. Curr. Drug Dis Tech, (2008) 5(4), 269-78.
- Williams, D. L., Connelly, M. A., Temel, R. E., Swarnakar, S., Phillips, M. C., de la Llera-Moya M and Rothblat, G. H. Scavenger receptor BI and cholesterol trafficking. Curr. Opin. Lipidol. (1999) 10, 329-339.
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