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Chemistry Division

Dr. Surajit Ghosh

Principal Scientist

  • Ramanujan Fellow at CSIR-IICB (January 2011-till date)
  • Postdoctoral Fellow (July 2008-December 2010), European Molecular Biology Laboratory, Heidelberg, Germany
  • Doctoral Fellow (July 2004-June 2008), Indian Institute of Technology Kanpur, India 
  • Scientist (January 2001- July 2004) Syngene International Limited (BIOCON GROUP), Bangalore, India

Contact - sgiicb@gmail.com / sghosh@iicb.res.in

Contact Phone No. +91-33-24995872

Dr. Ghosh's Lab Website (Click)

Award:

  • Travel grant by DBT/ Wellcome Trust for attending “EMBO Global Exchange & the Wellcome Trust/DBT India Alliance meeting” at Barcelona (2010)
  • Alexander von Humboldt Fellowship (2010-2012)
  • Travel grant by BASF for attending in International Symposium “BASF Conference on Nanomaterials” in Singapore (2007)
  • Biocon Tribute award for important contribution (A Biocon India Group, 2002)

Current Research Interest:

Broad Area: Interface between Chemistry and Biology

Specific areas we are currently working:

Development of small molecule and peptide based anti-Alzheimer therapeutics: We are trying to design novel small molecules and various peptides targeted to amyloid beta peptide for inhibiting the amyloid fibril formation. Successful lead molecules will be studied in details using in vitro assay and in vivo mice model.

Development of small molecule and peptide based anti-cancer therapeutics targeted to microtubule and Kinesin 5 (Eg5): We are involved in design and synthesis of small molecules and various peptides targeted to tubulin/microtubule and kinesin 5 (Eg5) for development of anti-cancer therapeutics. Successful lead molecules will be studied in details using in vitro assay and in vivo mice model

Development of various platforms for studying bio-molecular interactions through surface modification, patterning and using liposome: We are trying to develop various platforms for reconstitution of biological events. Recently, we have developed biotin and Tris-NTA functionalised EM grid, biotin micropatterned surface, micropatterned surface with the presence of Tris-NTA and biotin functionality both in same micropattern as well as individual in adjacent micropattern using UV light illumination through photo-mask, which is extremely useful for immobilization of oligohistidine and biotin tagged multiple biomolecules/proteins. We have also developed artificial cell like system using liposome for studying peptide-protein interaction with membrane. In addition we are working on development of other platforms for studying biomolecular interactions and drug delivery.

Understanding kinesin mediated cargo (nanomaterial) transport and microtubule dynamics: In eukaryotic cell molecular motor proteins, especially kinesins plays important role in cellular functions such as mitosis, meiosis and transport of cellular cargo. Kinesin moves along the microtubule using ATP as energy source. Kinesin, which moves towards the plus-end and minus-end of the microtubule known as plus-end directed and minus-end directed kinesin respectively. We are interested to learn in details about the transport of molecules using kinesin as transporter and nanomaterials as cargo. In addition we are trying to understand microtubule dynamics using microtubule tip binding protein Mal3 using FRET.

Understanding self-assembly of bio-inspired peptide and their interaction with membrane and tubulin: We are trying to understand how peptide self-assembles and forms various soft structures using molecular simulation and various microscopic techniques. In addition, we are also involved to find out mechanistic and structural insight about how this short peptide interacts with microtubule; an important cytoskeleton filament controls cell division. Few representative images from our recent finding are shown underneath.

Names of the group members including regular staff with designation and research fellows:

Position Available: PhD and Postdoctoral positions are available.
CSIR/UGC NET awardees with  a background in Organic Chemistry/ Biochemistry/Molecular Biology/ Biotechnology are welcome to apply.

Fellow/RA Staff Others
  1. Abhijit Saha, CSIR-SRF
  2. Batakrishna Jana, CSIR-SRF
  3. Prasenjit Mondal,CSIR-JRF
  4. Saswat Mohapatra,UGC-JRF
  5. Debmalya Bhunia,DST-JRF
  6. Anindyasundar Adak, UGC-JRF
  7. Subhajit Ghosh,CSIR-PF
  8. Surajit Barman,UGC-JRF
  9. Krishnangsu Pradhan,UGC-JRF
 

Thesis submitted:
Atanu Biswas, UGC-SRF

Our recent work in Front Cover Page.

 

List of Recent Publications:

1. Atanu Biswas, Prashant Kurkute, Suraiya Saleem, Batakrishna Jana, Saswat Mohapatra, Prasenjit Mondal, Anindyasundar Adak, Subhajit Ghosh, Abhijit Saha, Debmalya Bhunia, Subhash Chandra Biswas, and Surajit Ghosh*. Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection. ACS Chem. Neurosci.2015, DOI: 10.1021/acschemneuro.5b00149. 

2. Batakrishna Jana, Jayita Sarkar, Prasenjit Mondal, Surajit Barman, Saswat Mohapatra, Debmalya Bhunia, Krishnangsu Pradhan, Abhijit Saha, Anindyasundar Adak, Subhajit Ghosh and Surajit Ghosh*. A short GC rich DNA derived from microbial origin targets tubulin/microtubule and induces apoptotic death of cancer cell Chem.Commun. 2015,DOI: 10.1039/C5CC03432A  

3. Jyothi B Nair#, Saswat Mohapatra#, Surajit Ghosh*, Kaustabh K Maiti*. Novel Lysosome Targeted Molecular Transporter Built On Guanidinium-Poly-(propylene imine) Hybrid Dendron for Efficient Delivery of Doxorubicin into Cancer Cells. Chem.Commun. 2015,51, 2403-2406. 

4. Abhijit Saha, Saswat Mohapatra, Prashant Kurkute, Batakrishna Jana, Prasenjit Mondal, Debmalya Bhunia, Subhajit Ghosh and Surajit Ghosh*. Interaction of Aβ peptide with tubulin causes inhibition of tubulin polymerization and apoptotic death of cancer cells . Chem. Commun. 2015,51, 2249-2252. 

5. Batakrishna Jana, Atanu Biswas, Saswat Mohapatra, Abhijit Saha and Surajit Ghosh.* Single functionalized graphene oxide reconstitutes kinesin mediated intracellular cargo transport, delivers multiple cytoskeleton proteins and therapeutic molecule into the cell. Chem. Commun. 2014,50 (78), 11595-11598.

6. Atanu Biswas, Prashant Kurkute, Batakrishna Jana, Aparna Laskar and Surajit Ghosh.* Amyloid inhibitor octapeptide forms amyloid type fibrous aggregate and affect in microtubule motility. Chem. Commun., 2014, 50, 2604-7. 

7. Atanu Biswas,‡ Abhijit Saha,‡ Dhruba Ghosh, Batakrishna Jana and Surajit Ghosh.* Co- and distinct existence of Tris-NTA and biotin functionalities on individual and adjacent micropatterned surfaces generated by photo-destruction. Soft Matter, 2014, 10, 2341-45.

8. Abhijit Saha, Goutam Mondal, Atanu Biswas, Indrani Chakraborty, Batakrishna Jana and Surajit Ghosh.* In vitro reconstitution of a cellular like environment using liposome for amyloid beta peptide aggregation and its propagation. Chem. Commun., 2013, 49, 6119-6121.

9. Atanu Biswas, Abhijit Saha, Batakrishna Jana, Prashant Kurkute, Goutam Mondal and Surajit Ghosh.* Facile generation of biotin micropatterned surface by photo destruction serves as a novel platform for microtubule organisation and DNA hybridisation. ChemBioChem, 2013, 14, 689-694. 

10. Batakrishna Jana, Goutam Mondal, Atanu Biswas, Indrani Chakraborty, Abhijit Saha, Prashant Kurkute and Surajit Ghosh.* Dual functionalised graphene oxide serves as a carrier for delivering oligo-histidine and biotin tagged biomolecules into cell. Macromol Biosci. 2013, 13, 1478-1484.

All Detailed list of Publication == >> Go

 

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Updated on 4th August, 2015
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