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Chemistry Division

Dr. S. Mukhopadhyay, Scientist F
PhD,  University of Calcutta, 1979
Contact sibabrata @iicb.res.in

Current Research Interest

  • Isolation and characterization of bioactive  molecules from plant sources
  • Development of naturally occurring inhibitors  DNA topoisomerses 
  • Standardization of herbal formulation
  • Chemical Finger printing of herbal drugs
  • Chemical transformation of naturally occurring substances
Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff Others
  1. Mrs. Mumu Chakraborty(JRF-CSIR)
  2. Ms.Rashmi Roy ( JRF)
  3. Mr. Dipanjan Majumder (Proj. Asst.)
  4. Soumyanil Bhawmik(Proj.Asst.)
  5. Sruti Vishwakarma(Proj.Asst.)
  6. Mahua Bhattacharya(Proj.Asst.)
  1. Dr. S. Garai SctIV(1)
  2. Mr.S.Ghosh T.O.GrIII(5)
  3. Mr. S. Sarkhel Tech Gr.II(2)
  

List of important Publications:

  1. Murrayakoeninol, a New Carbazole Alkaloid from Murraya koenigii(Linn) Spreng,, Chakraborty,M, .Saha,S and Mukhopadhyay, S, Natural Product Communications    4,355-358 (2009)
  2. Withanolide Z, a New Chlorinated  Withanolide from Withania     somnifera Pramanick, Swapan Roy, Amit Ghosh, Shekher,. Majumder, Hemanta K  Mukhopadhyay, Sibabrata ,   Planta Med. 74,1745-1748 (2008)
  3. Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity, Sen, G.  Mukhopadhyay, S.,.Biswas, T,   J.Antimicrobial Chemothrapy, 61,1066-  1075 (2008)
  4. Molecular Mechanism of black tea polyphenols induced apoptosis in human skin cancer cell: Involvement of Bax translocation and mitrocondra mediated death cascade,  Halder, B. Bhattacharya, U.  .Mukhopadhyay, S and Giri, A. Carcinogenesis, 29, 129-138 (2008)
  5. Phytochemicals from the Genus Andrographis.Recent Progress in Medicinal Plants. .(Review article). Mukhapadhyay S, Pramanik S , Banerjee S, Achari B,vol-16,Phytomedicines,Studium Press,Houston,Texas 77072,U.S.A 339,(2007)
  6. Apoptosis is induced in leishmanial cells by a novel Protein Kinase Inhibitor Withaferin A and is facilitated by Apoptic Topoisomerase I DNA Complex.Sen N,Banerjee B,B B,Das B,Ganguly A,Sen T,Pramanik S,Mukhapadhyay S,Majumder H K.Cell Death & Differ.Cell Death Differ,14(2):358-67.(2007).
  7. Leishmania donovani .Dyskinetoplastid cells survive and proliferate in the presence of pyruvate and uridine but do not undergo apoptosis after treatment with camptothecin.  Sen A,Banerjee B,B B,Ganguly A.Sen T,Pramanik S,Mukhapadhyay S & Majumder HK.Experimental Parasitol ,115(2):215-9(2007)
  8. Andrographolide and Isoandrographolide,minor Diterpenoids from Andrographis paniculata: Structure and X-ray Crystallographic Analysis.Mukhapadhyay S,Pramanik S,Banerjee S,Achari B,Das B,Sen A K Sr.,A Neuman and T.Prange.J.Nat Prod.69,403,(2006).
  9. Hydroxylation through Acid Catalysed Epoxy Ring Opening of Betulinic Acid Derivatives.Mukhapadhyay S,Pramanik S,Mandal S,Jha S.Synth commun.35,2143(2005).
  10. Redetermination of 14-deoxyandrographolide. Mukhapadhyay S,Pramanik S, Bhattacharya K,Kar T,Bocelli G,Cantoni A.Acta Cryst.61,2743(2005).
  11. Bacopasaponin H:A pseudojujubogenin glycoside from Bacopa monniera.Mandal S, Mukhapadhyay S. Ind.J.Chem Sec B,43B,1802(2004).
  12. New Iridoid glucoside from Picrorhiza kurroa Royle ex benth- Mandal S, and Mukhapadhyay S. Ind.J.Chem Sec- B,43B,1023(2004).
  13. Medicinal and Aromatic Plants of Red Laterite region of West Bengal. [DST,NES.Govt.West Bengal,W.B.Acad.of Science & Technology],(2004).
  14. Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II:Implications in Antileishmanial Therapy.Roychowdhury A,Mandal S,Goswami A,Ghosh M,Mandal L,Chakraborty A,Ganguly G,Tripathi S,Mukhapadhyay S,Bandopadhyay S and Majumder H K.Molecular Medicine,9(1-2),26,(2003).
  15. Treatise on Indian Medicinal Plants”. [ed.Mrs.A.Chatterjee and S.C.Pakrashi], NISCAIR,CSIR,New Delhi,Vol.6(2001)
  16. Medicinal & Aromatic Plants of West Bengal:Midnapur Dist. [DST,NESGovt.West Bengal,W.B Acad of Science Tech.(2001). 13.Luteolin,an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II.Mittra B,Saha A,Roychowdhury C,Pal S,Mandal S,Mukhapadhyay S,and Majumder H K.Molecular Medicine,6(6),527-541(2000).

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Updated On 13.11.2009

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