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Chemistry Division

Dr. Sukhendu B Mandal, PhD

Chief Scientist
Contact - sbmandal@iicb.res.in

Current Research Interest

  • Synthesis of chiral heterocycles from carbohydrate derived precursors.
  • Development of synthetic methodology.
  • Synthesis of chiral carbo-nucleosides and spironucleosides starting from D-glucose.
  • Development of synthetic strategy for the generation of structurally unique bioactive molecules.
 
Names of the group members including regular staff with designation and research fellows:
Staff Fellow/RA  
  1. Mr. Sandip Chowdhury, TA Gr. III (2)
  2. Mr. Sankar Prasad Dutta, Sr. Stenographer (ACP)
  3. Mr. Nimai C Pradhan, Helper, Gr. I (3)
   

List of important Publications:

  1. A short and simple synthesis of 1-deoxynojirimycin derivatives from D-glucose; Ashim Roy, Basudeb Achari, Sukhendu B Mandal; Synthesis 2006, 1035. Erratum: A short and simple synthesis of 1-deoxynojirimycin derivatives from D-glucose; Ashim Roy, Basudeb Achari, Sukhendu B Mandal; Synthesis 2006, 2446. 
  2. Nucleoside synthesis from 3-alkylated sugars: role of 3β-oxy substituents in directing nucleoside formation; Sk. Sahabuddin, Ramprasad Ghosh, Basudeb Achari and Sukhendu B Mandal, Org. Biomol. Chem. 2006, 4, 551-557.
  3. An easy access to spiroannulated glyco-oxetane, -thietane and -azetane rings: synthesis of spironucleosides; Ashim Roy, Basudeb Achari, and Sukhendu B Mandal; Tetrahedron Letters 2006, 47, 3875-3879.
  4. Sequential ring closing metathesis and nitrone cycloaddition on glucose derived substrates:  divergent approach to analogues of spiroannulated carbanucleosides and conformationally locked nucleosides; Sk. Sahabuddin, Ashim Roy, Michael. G. B. Drew, Biswajit G Roy, Basudeb Achari and Sukhendu B Mandal; J. Org. Chem. 2006, 71, 5980-5992.
  5. A simple one-pot entry to cyclic ethers of varied ring sizes from diols via phosphonium ion     induced iodination and base catalyzed Williamson etherification, Biswajit Gopal Roy, Ashim Roy, Basudeb Achari, and Sukhendu B Mandal, Tetrahedron Letters 2006, 47, 7783-7787.
  6. Carbanucleosides: synthesis of both enantiomers of 2-(6-chloropurin-9-yl)-3,5-bishydroxymethyl cyclopentanol from D-glucose; Biswajit G Roy, Joy Krishna Maiti, Michael G. B. Drew, Basudeb Achari, and Sukhendu B Mandal, Tetrahedron Letters 2006, 47, 8821-8825.
  7. A short and efficient synthesis of 5-hydroxymethylcyclopent-2-enol from D-glucose and its elaboration to the carbanucleoside (-)-carbovir; Biswajit G Roy, Prithwish K Jana, Basudeb Achari, and Sukhendu B Mandal, Tetrahedron Letters 2007, 48, 1563-1566.
  8. First example of 5/6-O-linked pseudosaccharides: synthesis of bicyclic nucleosides containing azido or extended carbohydrate moiety; Joy Krishna Maity, Subhranshu Mukherjee, Michael G. B. Drew, Basudeb Achari, and Sukhendu B. Mandal, Carbohydr. Res. 2007, 342,2511-2521.
  9. Synthesis of oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides from D-glucose: a cycloaddition approach; Subhankar Tripathi, Biswajit Gopal Roy, Michael G. B. Drew, Basudeb Achari, and Sukhendu B Mandal, J. Org. Chem. 2007, 72, 7427-7430.
  10. Introduction of Vinyl and Hydroxymethyl Functionalities at C-4 of Glucose  Derived Substrates: Synthesis of Spirocyclic, Bicyclic and Tricyclic  Nucleosides; Joy Krishna Maity, Ramprasad Ghosh, Michael G. B. Drew, Basudeb Achari, and Sukhendu B. Mandal; J. Org. Chem. 2008, 73, 4305- 4308.
  11. A synthetic route to fully substituted chiral cyclopentyl amine derivatives: precursors of carbanucleosides; Ramprasad Ghosh, Joy Krishna Maity, Michael G. B. Drew, Basudeb Achari, and Sukhendu B Mandal; Synthesis 2010, 1303-1310.
  12. Locked nucleosides based on oxabicyclo[3.2.1]octane and oxabicyclo[2.2.1]heptane skeletons; Ramprasad Ghosh, Joy Krishna Maity, Basudeb Achari and Sukhendu B Mandal; J. Org. Chem. 2010, 75, 2419-2422.
  13. Synthesis of carbohydrate derived 1-oxaspiro[4.4]nonane skeleton and its conversion to spironucleosides; Joy Krishna Maity, Basudeb Achari, Michael G. B. Drew, Sukhendu B Mandal; Synthesis 2010, 2533-2542.

Detail list of Publications upto March'2012 ==>> Click here

 

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Updated on 19th April'2012
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