Dr. Sukhendu B Mandal, PhD
Scientist G
Contact - sbmandal@iicb.res.in
Current Research Interest
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Synthesis of chiral heterocycles from carbohydrate derived precursors.
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Development of synthetic methodology.
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Synthesis of chiral carbo-nucleosides and spironucleosides starting from D-glucose.
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Development of synthetic strategy for the generation of structurally unique bioactive molecules.
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| Names of the group members including regular staff with designation and research fellows: |
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Fellow/RA |
Others |
- Mr. Sandip Chowdhury, TA Gr. III (2)
- Mr. Sankar Prasad Dutta, Sr. Stenographer (ACP)
- Mr. Nimai C Pradhan, Helper, Gr. I (3)
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- Mr. Ram Prasad Ghosh, SRF
- Mr. Subhrangsu Mukherjee, SRF
- Mr. Prithwish K Jana, SRF
- Mr. Soumendra Nath Das, Roject Assistant
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List of important Publications:
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A short and simple synthesis of 1-deoxynojirimycin derivatives from D-glucose; Ashim Roy, Basudeb Achari, Sukhendu B Mandal; Synthesis 2006, 1035. Erratum: A short and simple synthesis of 1-deoxynojirimycin derivatives from D-glucose; Ashim Roy, Basudeb Achari, Sukhendu B Mandal; Synthesis 2006, 2446.
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Nucleoside synthesis from 3-alkylated sugars: role of 3β-oxy substituents in directing nucleoside formation; Sk. Sahabuddin, Ramprasad Ghosh, Basudeb Achari and Sukhendu B Mandal, Org. Biomol. Chem. 2006, 4, 551-557.
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An easy access to spiroannulated glyco-oxetane, -thietane and -azetane rings: synthesis of spironucleosides; Ashim Roy, Basudeb Achari, and Sukhendu B Mandal; Tetrahedron Letters 2006, 47, 3875-3879.
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Sequential ring closing metathesis and nitrone cycloaddition on glucose derived substrates: divergent approach to analogues of spiroannulated carbanucleosides and conformationally locked nucleosides; Sk. Sahabuddin, Ashim Roy, Michael. G. B. Drew, Biswajit G Roy, Basudeb Achari and Sukhendu B Mandal; J. Org. Chem. 2006, 71, 5980-5992.
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A simple one-pot entry to cyclic ethers of varied ring sizes from diols via phosphonium ion induced iodination and base catalyzed Williamson etherification, Biswajit Gopal Roy, Ashim Roy, Basudeb Achari, and Sukhendu B Mandal, Tetrahedron Letters 2006, 47, 7783-7787.
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Carbanucleosides: synthesis of both enantiomers of 2-(6-chloropurin-9-yl)-3,5-bishydroxymethyl cyclopentanol from D-glucose; Biswajit G Roy, Joy Krishna Maiti, Michael G. B. Drew, Basudeb Achari, and Sukhendu B Mandal, Tetrahedron Letters 2006, 47, 8821-8825.
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A short and efficient synthesis of 5-hydroxymethylcyclopent-2-enol from D-glucose and its elaboration to the carbanucleoside (-)-carbovir; Biswajit G Roy, Prithwish K Jana, Basudeb Achari, and Sukhendu B Mandal, Tetrahedron Letters 2007, 48, 1563-1566.
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First example of 5/6-O-linked pseudosaccharides: synthesis of bicyclic nucleosides containing azido or extended carbohydrate moiety; Joy Krishna Maity, Subhranshu Mukherjee, Michael G. B. Drew, Basudeb Achari, and Sukhendu B. Mandal, Carbohydr. Res. 2007, 342,2511-2521.
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Synthesis of oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides from D-glucose: a cycloaddition approach; Subhankar Tripathi, Biswajit Gopal Roy, Michael G. B. Drew, Basudeb Achari, and Sukhendu B Mandal, J. Org. Chem. 2007, 72, 7427-7430.
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Introduction of Vinyl and Hydroxymethyl Functionalities at C-4 of Glucose Derived Substrates: Synthesis of Spirocyclic, Bicyclic and Tricyclic Nucleosides; Joy Krishna Maity, Ramprasad Ghosh, Michael G. B. Drew, Basudeb Achari, and Sukhendu B. Mandal; J. Org. Chem. 2008, 73, 4305- 4308.
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