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Chemistry Division

Dr. Sanjay Dutta
Senior Scientist

Ph.D (2007)    Organic Chemistry/Bio-organic Chemistry, University of Missouri, Columbia MO, USA (Prof. Kent S. Gates)
Post-doctoral Research Scholar (2007-2010), University of California-San Diego, California, USA (Prof. Thomas Hermann)
Research Associate, (2011-2012), The Scripps Research Institute, La Jolla, California,USA (Prof M. G Finn)


Contact - sdutta51@gmail.com
; sanjaydutta@iicb.res.in

Current Research Interest

Targeting nucleic acids (DNA & RNA) by small molecules based on natural products, carbohydrates and heterocycles.

  • Targeting viral RNA (Hepatitis C Virus) and bacterial RNA, development of RNA targeted therapy.
  • Exploring the mechanisms of actions of natural compounds targeting DNA, which will ultimately be utilized for targeting particular diseases and discovery of drug like molecules.
  • Targeting cellular receptors for drug delivery to liver.
  • Organic synthesis, medicinal chemistry, bioorganic and nucleic acid chemistry and chemical biology.
 

Names of the group members including regular staff with designation and research fellows:

Positions Available: CSIR/UGC NET awardees with a background in Organic Chemistry/ Biochemistry/Microbiology/Molecular Biology are welcome to apply via e-mail to sdutta51@gmail.com

  Fellow/RA
 
  1. Ajay Kanungo (Chemistry Graduate Student, GATE, CSIR-JRF)
  2. Kalyani Kashimalla (Chemistry Graduate Student, GATE, CSIR-JRF)
  3. Tridib Mahata (Biology Graduate Student, CSIR, JRF)
  4. Saikat Banerjee (Chemistry Graduate Student, CSIR, JRF)
  5. Debiprasad Satpati (Chemistry Graduate Student, UGC-NET, JRF)

List of important Publications:

  1. On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA.  Johnson K. M, Price N. E, Wang J, Fekry M. I, Dutta S, Seiner D. R, Wang Y, Gates K. S J. Am. Chem. Soc., 2013, 135, 1015-25
  2. Glycomimetic Ligands for the Human Asialoglycoprotein Receptor.  Mamidyala, S.  K§.; Dutta, S§.; Chrunyk, B. A.; Préville, C.; Wang, H.; Withka, J. M.; McColl, A.; Subashi, T. A.; Hawrylik, S. J.; Griffor, M. C.; Kim, S.; Pfefferkorn, J. A.; Price, D. A.; Menhaji-Klotz, E.; Mascitti, V. and Finn. M.G.  J. Am. Chem. Soc., 2012, 134, 1978–1981
    (§These authors contributed equally.)
  3. Synthesis and crystal structure of a novel heterocycle, 2-oxa-4,7-diazabicyclo[3.3.1]non-3-ene.  Dutta, S.; Dibrov, SM.; Ho, BT.; Higginson, C. J.; & Hermann T. J. Chem.Cryst. 2012, 42, 119-129.
  4. Noncovalent DNA Binding Drives DNA Alkylation by Leinamycin: Evidence That the Z,E-5-(Thiazol-4-yl)-penta-2,4-dienone Moiety of the Natural Product Serves as an Atypical DNA Intercalator. Fekry, M.; Szekely, J.; Dutta, S.; Breydo, L.; Zang, H.; Gates, K. S. J. Am. Chem. Soc. 2011, 132.
  5. A crystallographic study of a highly substituted imidazolinone, (3S,4S,5R)-3-(((S)-4-((1H-indol-3-yl)methyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxypiperidin-2-one  Dutta, S, Dibrov SM, Higginson CJ & Hermann T. J. Chem.Cryst. 2011, 41, 1573-1578.
  6. 1, 3-Diazepanes of Natural Product-Like Complexity from Cyanamide-Induced Rearrangement of Epoxy-δ-lactams. Dutta, S.; Higginson, C. J.; Bao, T. Ho.; Rynearson, K. D.; Dibrov, S. M. And Hermann, T.; Organic Letters, 2010, 12, 360-363
  7. 1-Cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid. Dibrov, S.; Dutta, S. and Hermann, T. Acta Cryst. (2009). E65, o2136
  8. Conformational inhibition of the HCV IRES RNA. Parsons, J.; Castaldi, M. P.; Dutta, S.; Dibrov, S. M.; Wyles, D. L. and Hermann, T. Nature. Chem. Biol, 2009, 5, 823-825. (Reported in News and Views by D. W Begley & G Varani in the same Journal)
  9. Synthesis and Biological Evaluation of New 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide Derivatives and Their Reduced Analogue. Solano, B.; Junnotula, V.; Martin, Adoracion.; Villar, R.; Burguette, A.; Vicente, E.; Silanes, S. P.; Aldana, I.; Mongoe, A.; Dutta, S.; Sarkar, U.; Gates, K. S.     J. Med. Chem., 2007, 50 (22), pp 5485–5492
  10. Interstrand crosslinks generated by abasic sites in duplex DNA. Dutta, S.; Chowdhury, G.; and Gates, K. S. J. Am. Chem. Soc. 2007, 129, 1852-1853
  11. DNA Damage by Fasicularin. Dutta, S.; Abe, H.; Aoyagi, S.; Kibayashi, C.; and Gates, K. S. J. Am. Chem. Soc. 2005, 127, 15004-15005
  12. Biologically Relevant Chemical Reactions of N7-Alkylguanine Residues in DNA. Gates, K. S.; Nooner, T and Dutta, S. Chem. Res. Toxicol, 2004, 17, 839-856
  13. Chemical Properties of the Leinamycin-Guanine Adduct in DNA. Nooner, T.; Dutta, S and Gates, K. S. Chem. Res. Toxicol, 2004, 17, 942-949

 

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Updated on 18th July'2013

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