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Chemistry Division

Dr. Sanjay Dutta
Senior Scientist

Ph.D (2007)    Organic Chemistry/Bio-organic Chemistry, University of Missouri, Columbia MO, USA (Prof. Kent S. Gates)
Post-doctoral Research Scholar (2007-2010), University of California-San Diego, California, USA (Prof. Thomas Hermann)
Research Associate, (2011-2012), The Scripps Research Institute, La Jolla, California,USA (Prof M. G Finn)


Contact - sdutta51@gmail.com
; sanjaydutta@iicb.res.in

Current Research Interest

Our laboratory is working in an interdisciplinary approach to find solutions related to antivirals and antibiotic and anticancer therapy. We have students both from chemistry and biology discipline working for the common goal. Hepatitis C Virus (HCV) infection is one of the major liver diseases and is a global health concern. HCV infection affects almost 175 million people worldwide which represent almost 3% of the world population. HCV infection in liver leads to liver failure and hepatocellular carcinoma. Till date absolute therapy of Hepatitis C virus is problematic. There is an urgent need for the development of antivirals targeting HCV infection. My laboratory at IICB-Kolkata is engaged in the discovery and development of novel antivirals targeting Hepatitis C virus RNA.

Asialoglycoprotein receptor (ASGPR) is a high capacity galactose-binding receptor expressed on hepatocytes that binds with its natural substrates (such as GalNAc, Me-Gal, Lactose) with low affinity. ASGPR plays an important role in the lysosomal processing of N-acetylgalactosamine (GalNAc) and galactose (Gal) containing glycopeptide substrates. The ASGPR is predominantly expressed on the basolateral surface of mammalian hepatocytes and is responsible for the clearance of glyco- and lipoproteins. In our laboratory the research is focused on the delivery of HCV targeting small molecules with this asialoglycoprotein receptor pathway.

Current Research Interests:

Targeting nucleic acids (DNA & RNA) by small molecules based on natural products, carbohydrates and heterocycles.

  • Targeting viral RNA (Hepatitis C Virus) and bacterial RNA by small molecules, development of RNA targeted therapy. Delivery of RNA targeting molecules to hepatocytes. Study of interaction of specific liver receptors with Virus like particles.
  • Designing novel DNA binding/damaging agents and study of their anticancer properties.
  • Organic synthesis, medicinal chemistry, bioorganic and nucleic acid chemistry and Chemical & Molecular Biology.

 

 

Names of the group members including regular staff with designation and research fellows:

Positions Available:
Urgently needed: CSIR/UGC NET awardees with a background in Molecular Biology/ Biochemistry/Microbiology/Biotechnology are welcome to apply via e-mail to sdutta51@gmail.com, sanjaydutta@iicb.res.in

  Fellow/RA
 
  1. Ajay Kanungo (Chemistry Graduate Student, GATE, CSIR-JRF)
  2. Tridib Mahata (Biology Graduate Student, UGC-NET, SRF)
  3. Subhadeep Palit (Chemistry Graduate Student, CSIR-NET, JRF)
  4. Dipendu Patra (Chemistry Graduate Student, CSIR-NET, JRF)
  5. Sanghamitra Mukherjee (Research Associate-Biology, DBT-RA)
  6. Amit Chakravarty (M.Tech Thesis, CU)

List of important Publications:

  1. 1. Rynearson KD, Dutta S, Tran K, Dibrov SM & Hermann T. Synthesis of oxazole analogs of streptolidine lactam (2013) Eur. J. Org Chem., 7337-7342.
  2. On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA. Johnson K. M, Price N. E, Wang J, Fekry M. I, Dutta S, Seiner D. R, Wang Y, Gates K. S J. Am. Chem. Soc., 2013, 135, 1015-25
  3. Glycomimetic Ligands for the Human Asialoglycoprotein Receptor. Mamidyala, S. K§.; Dutta, S§.; Chrunyk, B. A.; Préville, C.; Wang, H.; Withka, J. M.; McColl, A.; Subashi, T. A.; Hawrylik, S. J.; Griffor, M. C.; Kim, S.; Pfefferkorn, J. A.; Price, D. A.; Menhaji-Klotz, E.; Mascitti, V. and Finn. M.G. J. Am. Chem. Soc., 2012, 134, 1978–1981
    (§These authors contributed equally.)
  4. Synthesis and crystal structure of a novel heterocycle, 2-oxa-4,7-diazabicyclo[3.3.1]non-3-ene. Dutta, S.; Dibrov, SM.; Ho, BT.; Higginson, C. J.; & Hermann T. J. Chem.Cryst. 2012, 42, 119-129.
  5. Noncovalent DNA Binding Drives DNA Alkylation by Leinamycin: Evidence That the Z,E-5-(Thiazol-4-yl)-penta-2,4-dienone Moiety of the Natural Product Serves as an Atypical DNA Intercalator. Fekry, M.; Szekely, J.; Dutta, S.; Breydo, L.; Zang, H.; Gates, K. S. J. Am. Chem. Soc. 2011, 132
  6. A crystallographic study of a highly substituted imidazolinone, (3S,4S,5R)-3-(((S)-4-((1H-indol-3-yl)methyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxypiperidin-2-one Dutta, S, Dibrov SM, Higginson CJ & Hermann T. J. Chem.Cryst. 2011, 41, 1573-1578
  7. 1, 3-Diazepanes of Natural Product-Like Complexity from Cyanamide-Induced Rearrangement of Epoxy-δ-lactams. Dutta, S.; Higginson, C. J.; Bao, T. Ho.; Rynearson, K. D.; Dibrov, S. M. And Hermann, T.; Organic Letters, 2010, 12, 360-363
  8. 1-Cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid. Dibrov, S.; Dutta, S. and Hermann, T. Acta Cryst. (2009). E65, o2136.
  9. Conformational inhibition of the HCV IRES RNA. Parsons, J.; Castaldi, M. P.; Dutta, S.; Dibrov, S. M.; Wyles, D. L. and Hermann, T. Nature. Chem. Biol, 2009, 5, 823-825. (Reported in News and Views by D. W Begley & G Varani in the same Journal)
  10. 10. Synthesis and Biological Evaluation of New 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide Derivatives and Their Reduced Analogue. Solano, B.; Junnotula, V.; Martin, Adoracion.; Villar, R.; Burguette, A.; Vicente, E.; Silanes, S. P.; Aldana, I.; Mongoe, A.; Dutta, S.; Sarkar, U.; Gates, K. S. J. Med. Chem., 2007, 50 (22), pp 5485–5492
  11. Interstrand crosslinks generated by abasic sites in duplex DNA. Dutta, S.; Chowdhury, G.; and Gates, K. S. J. Am. Chem. Soc. 2007, 129, 1852-1853
  12. DNA Damage by Fasicularin. Dutta, S.; Abe, H.; Aoyagi, S.; Kibayashi, C.; and Gates, K. S. J. Am. Chem. Soc. 2005, 127, 15004-15005
  13. Biologically Relevant Chemical Reactions of N7-Alkylguanine Residues in DNA. Gates, K. S.; Nooner, T and Dutta, S. Chem. Res. Toxicol, 2004, 17, 839-856.
  14. Chemical Properties of the Leinamycin-Guanine Adduct in DNA. Nooner, T.; Dutta, S and Gates, K. S. Chem. Res. Toxicol, 2004, 17, 942-94.

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Updated on 10thApril,2015

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