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Chemistry Division


Dr. Indrajit Das

Scientist

Education and Experience:

B.Sc. (1999): Ramakrishna Mission Residential College - Narendrapur, Calcutta University, Kolkata
M.Sc. (2001): Rajabazar Science College, Calcutta University, Kolkata
Ph.D. (January 2002 – December 2006): with Prof. Tanmaya Pathak, Indian Institute of Technology, Kharagpur, India
Postdoctoral Fellow (January 2007 – January 2009): with Prof Jean-Luc Decout, DPM-University Joseph Fourier, Grenoble/CNRS, France (IFCPAR Fellowship)

Contact : id@csiriicb.in / indrajit_sad@yahoo.com

Contact Phone No. : +91-33-24995793


 

Current Research Interest :

  1. Development of new reagent systems, synthetic transformations, and mechanistic aspects
  2. Gold-catalyzed C-C and C-heteroatom bond formation
  3. Novel methodologies for bioactive heterocycles, especially substituted furans and pyrans

Positions Available:

Ph.D and Postdoctoral positions are available.
CSIR/UGC NET awardees with a background in Organic Chemistry are welcome to apply via e-mail.

Names of the group members including regular staff with designation and research fellow:

  1. Mr. Kanchan Mal (SRF, CSIR); e-mail: kanchan01809@gmail.com     

Position Available:

Ph.D and Postdoctoral positions are available.
CSIR/UGC NET awardees with a background in Organic Chemistry are welcome to apply via e-mail.

List of important Publications and Patents:

[2014]

11. U.S. Patent: PNA-aminoglucosamine conjugates as antiviral agents By Virendra N Pandey, Jean-Luc Decout, Indrajit Das, Jérôme Désiré; US non-provisional application was filed on 13/06/2014, Rutgers ref: S11-001- - VHP ref: 00835.064US1.

Abstract: The present invention pertains to the use of nucleic acid oligomer-glucosamine conjugates as therapeutic agents.

10. Gold(III) Chloride Catalyzed Synthesis of Chiral Substituted 3-Formyl Furans from Carbohydrates: Application to the Synthesis of 1,5-Dicarbonyl Derivative and Furo[3,2-c]pyridine By Kanchan Mal, Abhinandan Sharma, and Indrajit Das,* Chemistry - A European Journal (Full Paper), 2014 (In Press). (Impact Factor: 5.831)

Abstract: A gold(III)-catalyzed efficient access to substituted chiral 3-formyl furans under extremely mild conditions from suitably protected 5-(1-alkynyl)-2,3-dihydro-pyran-4-ones and H2O as a nucleophile are described. The latter can easily be synthesized from appropriately functionalized monosaccharides or commercially available glycals in a few steps following oxidation, iodination, and Sonogashira coupling sequences. Furthermore, synthesis of furo[3,2-c]pyridine from chiral 3-formyl furans has also been achieved via a TiBr4-catalyzed conversion to 1,5-dicarbonyl compound followed by treatment with NH4OAc in acidic medium.   

9. PPh3.HBr-DMSO mediated expedient synthesis of γ-substituted β,γ-unsaturated α-ketomethylthioesters and α-bromo enals: Application to the synthesis of 2-methylsulfanyl-3(2H)-furanones By Kanchan Mal, Abhinandan Sharma, Prakas R. Maulik, and Indrajit Das,* Chemistry - A European Journal (Communication), 2014, 20, 662 – 667. (Impact Factor: 5.831)

Abstract: An efficient chemoselective general procedure for the synthesis of γ-substituted β,γ-unsaturated α-ketomethylthioesters from α,β-unsaturated ketones has been achieved through an unprecedented PPh3.HBr-DMSO mediated oxidative bromination and Kornblum oxidation sequence. The newly developed reagent system serves admirably well for the synthesis of α-bromoenals from enals. Furthermore, AuCl3-catalyzed efficient access to 3(2H)-furanones from the above intermediates under extremely mild conditions are described.

Previous Publications and Patents:

8. A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-mediated Transactivation of HIV-1 Transcription By Indrajit Das, Jérôme Désiré, Dinesh Kumar Manvar, Isabelle baussanne, Virendra N Pandey, and Jean-Luc Decout* J. Med. Chem.,2012, 5, 6021–6032.

7. 6-amino-6-deoxyglucosamine derivatives and their use as antibacterial agents By Jean-Luc Decout,* Isabelle Baussanne, Jerome Desire, Indrajit Das, and Marie-Paule Mingeot-Leclercq PCT Int. Appl. 2012, WO 2012062996 A1 20120518.

6. 6-amino-6-deoxyglucosamine derivatives and their use as antibacterial agents By Jean-Luc Decout,* Indrajit Das, Jerome Desire, Isabelle Baussanne, and Marie-Paule Mingeot-Leclercq Fr. Demande, 2012, FR 2967068 A1 20120511.

5. Unusual addition of amines to C-2 of vinyl sulfone-modified-β-d-pent-2-enofuranosyl carbohydrates: synthesis of a new class of β-anomeric 2-amino-2,3-dideoxy-d-threo-pentofuranosides By Indrajit Das, Cheravakkattu G. Suresh, Jean-Luc Décout, and Tanmaya Pathak* Carbohydr. Res., 2008, 343, 1287-1296.

4. Diastereoselective Michael Initiated Ring Closure on Vinyl Sulfone-Modified Carbohydrates: A Stereospecific and General Route to α-Substituted Cyclopropanes By Indrajit Das, Tarun K. Pal, and Tanmaya Pathak* J. Org. Chem., 2007, 72 (24), 9181–9189.

3. Diastereoselective C−C Bond Formation at C-5 of Vinyl Sulfone-Modified Hex-5-enofuranosyl Carbohydrates: Diversity-Oriented Synthesis of Branched-Chain Sugars and Beyond By Indrajit Das, Tarun K. Pal, Cheravakkattu G. Suresh, and Tanmaya Pathak* J. Org. Chem., 2007, 72 (15), 5523–5533.

2. Desulfonylation with Mg−MeOH−NiBr2: An Expedient Reagent System for the Synthesis of 2-Amino-2,3-dideoxy Furanosides By Indrajit Das and Tanmaya Pathak* Org. Lett., 2006, 8 (7), 1303–1306.

1. A Diastereoselective and General Route to 5-Amino-5-deoxysugars: Influence of C-3 Substitution on the Addition of Amines to C-5 of Vinyl Sulfone-Modified Hex-5-enofuranosyl Carbohydrates By Indrajit Das, Tanmaya Pathak*, and Cheravakkattu G. Suresh J. Org. Chem., 2005, 70 (20), 8047–8054.

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Updated on 18th June 2014
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