Current Research Interest :
Development of New Synthetic Methods and Strategies in Carbohydrates and Nucleic Acids; Total Synthesis of Carbohydrate derived Natural Products.
Positions Available:
Ph.D and Postdoctoral positions are available.
CSIR/UGC NET awardees with a background in Organic Chemistry are welcome to apply via e-mail to id@csiriicb.in / indrajit_sad@yahoo.com
Names of the group members including regular staff with designation and research fellow:
- Mr. Kanchan Mal (JRF, CSIR)
- Mr. Suman Mallick (JRF, UGC)
List of important Publications:
1. A Diastereoselective and General Route to 5-Amino-5-deoxysugars: Influence of C-3 Substitution on the Addition of Amines to C-5 of Vinyl Sulfone-Modified Hex-5-enofuranosyl Carbohydrates By Indrajit Das, Tanmaya Pathak, and Cheravakkattu G. Suresh J. Org. Chem., 2005, 70 (20), 8047–8054.
2. Desulfonylation with Mg−MeOH−NiBr2: An Expedient Reagent System for the Synthesis of 2-Amino-2,3-dideoxy Furanosides By Indrajit Das and Tanmaya Pathak Org. Lett., 2006, 8 (7), 1303–1306.
3. Diastereoselective Michael Initiated Ring Closure on Vinyl Sulfone-Modified Carbohydrates: A Stereospecific and General Route to α-Substituted Cyclopropanes By Indrajit Das, Tarun K. Pal, and Tanmaya Pathak J. Org. Chem., 2007, 72 (24), 9181–9189.
4. Diastereoselective C−C Bond Formation at C-5 of Vinyl Sulfone-Modified Hex-5-enofuranosyl Carbohydrates: Diversity-Oriented Synthesis of Branched-Chain Sugars and Beyond By Indrajit Das, Tarun K. Pal, Cheravakkattu G. Suresh, and Tanmaya Pathak J. Org. Chem., 2007, 72 (15), 5523–5533.
5. Unusual addition of amines to C-2 of vinyl sulfone-modified-β-d-pent-2-enofuranosyl carbohydrates: synthesis of a new class of β-anomeric 2-amino-2,3-dideoxy-d-threo-pentofuranosides By Indrajit Das, Cheravakkattu G. Suresh, Jean-Luc Décout, and Tanmaya Pathak Carbohydr. Res., 343 (8), 2008, 1287-1296.
6. 6-amino-6-deoxyglucosamine derivatives and their use as antibacterial agents By Jean-Luc Decout, Indrajit Das, Jerome Desire, Isabelle Baussanne, and Marie-Paule Mingeot-Leclercq Fr. Demande, 2012, FR 2967068 A1 20120511.
7. 6-amino-6-deoxyglucosamine derivatives and their use as antibacterial agents By Jean-Luc Decout, Isabelle Baussanne, Jerome Desire, Indrajit Das, and Marie-Paule Mingeot-Leclercq PCT Int. Appl. 2012, WO 2012062996 A1 20120518.
8. A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-mediated Transactivation of HIV-1 Transcription By Indrajit Das, Jérôme Désiré, Dinesh Kumar Manvar, Isabelle baussanne, Virendra N Pandey, and Jean-Luc Decout J. Med. Chem. ; just accepted 2012.
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