Chemistry Division

Dr. G. Suresh Kumar

PhD, University of Delhi, 1987
Postdoctoral Research
City University of New York- Hunter College, New York, USA
(1993-1995 and 1999-2001)

Contact - gskumar@iicb.res.in / gsk.iicb@gmail.com


Chief Scientist

Current Research Interest

  1. Micro RNA-mRNA interaction.
  2. DNA and RNA polymorphism.
  3. Interaction of Drugs with DNA and RNA: Molecular basis of the antitumor action of alkaloids through biophysical studies.
  4. Binding of a number of medically important natural products and small molecules to polymorphic nucleic acid structures like duplex, triplex and quadruplexes.
  5. Photochemistry and photobiology of alkaloids.

Names of the group members including regular staff with designation and research fellows

Fellow / RA / PA

1. Dr. Shrabanti Kumar, Women Scientist (WOS-A), E-Mail:kumarsra@yahoo.com
2. Dr. Abhi Das, Project Associate, E-Mail: abhi.das8310@yahoo.co.in
3. Dr. Anirban Basu, Project Associate, E-Mail: basu.ani.anirban@gmail.com
4. Dr. Asma Yasmeen Khan, Research Associate-CSIR, E-mail: asmayasmeenkhan@gmail.com
5. Mr. Soumitra Hazra, SRF, CSIR, E-mail: soumitrahazra88@gmail.com
6. Ms. Pritha Basu, SRF, UGC, E-mail: titli.prithabasu1988@gmail.com
7. Ms. Baishakhi Saha, SRF, UGC, E-mail: baishakhi.saha10@gmail.com
8. Mr. Sabyasachi Chatterjee, SRF, UGC, E-mail: sc.iicb13@gmail.com

List of important Publications

  1. Saha B and Suresh Kumar G* (2016) Spectroscopic and calorimetric investigations on the binding of phenazinium dyes safranine O and phenosafranine to double stranded RNA polynucleotides. J. Photochem. Photobiol. B Biology (in press).
  2. Bhowmik, D and Suresh Kumar, G* (2016) A Study of the interaction of amsacrine with heme proteins: Photophysical and calorimetric approach. J. Biomol. Struct. Dyn. (in press).
  3. Chatterjee, S and Suresh Kumar, G* (2016) Probing the binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin and elucidation of their molecular recognition by spectroscopic, calorimetric and molecular modeling techniques. J. Photochem. Photobiol. B Biology (in press).
  4. Basu, P and Suresh Kumar, G* (2016) Sanguinarine and its role in chronic diseases. Adv. Exptl. Med. Biol. (in press)
  5. Roy, A, Chaterjee, S, Pramanik, S, Devi, P.S and Suresh Kumar, G (2016) Selective detection of Escherichia coli DNA by blue emitting carbon nanostructures. Phys. Chem. Chem. Phys. (in press).
  6. Basu, A and Suresh Kumar, G* (2015). Spectroscopic and microcalorimetric studies on the molecular binding of food colorant acid red 27 with deoxyribonucleic acid. J. Mol. Recog. (in press)
  7. Basu, A and Suresh Kumar, G* (2016) Studies on the interaction of the food colorant tartrazine with double stranded deoxyribonucleic acid. J. Biomol. Struct. Dyn. (in press).
  8. Suresh Kumar G* and A. Basu (2016) The use of calorimetry in the biophysical characterization of small molecules binding to RNA structures. Biochim. Biophys. Acta 860(5), 930-944.
  9. Das, A and Suresh Kumar, G* (2016) Binding of the alkaloid aristololactam-β-D-glucoside and daunomycin to human hemoglobin: spectroscopy and calorimetry studies. J. Biomol. Struct. Dyn. 34(4), 800-813.
  10. Basu, A and Suresh Kumar, G (2016) Calorimetric investigation on the interaction of proflavine with human telomeric G-quadruplex DNA. J. Chem. Thermodyn 98, 208-213.
  11. Guhathakurta, B, Basu, P, Suresh Kumar, G, Lu, L, Zhu, M, Bandyopadhyay, N, Naskar, J. P (2016) Synthetic, structural, electrochemical and DNA-binding aspects of a novel oximato bridged copper(II) dimer. Polyhedron. 110, 227–234.
  12. Saha, B and Suresh Kumar, G* (2016) 2 Calorimetry and thermal analysis studies on the binding of janus green blue to calf thymus DNA. J. Thermal Anal. Calorim. 123, 1993-2001.
  13. Basu, A and Suresh Kumar, G* (2016) A microcalorimetric study on the binding of proflavine with tRNAphe. J. Chem. Thermodyn. 97, 173-178.
  14. Maity, P, Saha, B, Suresh Kumar, G and Karmakar, S (2016) Binding of monovalent alkali metal ions with negatively charged phospholipid membranes. Biochim. Biophys. Acta- Biomembranes. 1858(4),706-714.
  15. Kabir, A and Suresh Kumar, G* (2016) Targeting of 1-naphthyl acetyl spermine with DNA: A spectroscopic and calorimetric investigation. J. Chem. Thermodyn. 94, 52–60.
  16. Bhowmik, D and Suresh Kumar, G* (2016) Recent advances in nucleic acid binding aspects of berberine analogues and implications for drug design. Mini Rev. Med. Chem. 16(2), 104-109.
  17. Patra, A. Hazra, S, Samanta, N, Suresh Kumar, G* and Mitra, R. K (2015) Micelle induced dissociation of DNA-ligand complexes: the effect of ligand binding specificity. Int. J. Biol. Macromol. 82, 418–424.
  18. Khan, A.Y and Suresh Kumar G* (2015) Natural isoquinoline alkaloids: Binding aspects to functional proteins, serum albumins, hemoglobin and lysozyme. Biophys. Rev. 7(4), 407-420.
  19. Kundu, S, Banerjee, A, De, A., Khan, A.Y, Suresh Kumar, G, Bhadra, R and Ghosh, P (2015) Synthesis, fluorescence spectra, redox property and the DNA binding studies of 7- phenylacenaphtho[1,2-b]quinoxalin-7-ium chloride: evidences of the formation of neutral radical
    analogue, J. Fluorescence 25(6),1637-1643.
  20. Bhowmik, D., Fiorillo, G., Lombardi, P and Suresh Kumar G* (2015) Recognition of Human telomeric G-quadruplex DNA by berberine analogs: Effect of substitution at the 9 and 13 positions of the isoquinoline moiety. J. Mol. Recog. 28,722–730.
  21. Basu, P and Suresh Kumar, G* (2015) A spectroscopy and calorimetry study on the Interaction of sanguinarine and chelerythrine with single and double stranded, and heat denatured DNA. J. Biomol. Struct. Dyn. 33, 2594–2605.
  22. Chatterjee, S Mallick, S Buzzetti, F Fiorillo, G, Syeda T M, Lombardi, P, Saha, K.D and Suresh Kumar, G* (2015) New 13-pyridinealkyl berberine analogues intercalate to DNA and induce apoptosis in HepG2 and MCF-7 cells through ROS mediated P53 dependent pathway: Biophysical, biochemical and molecular modeling studies. RSC Adv. 5, 90632 - 90644.
  23. Khan, A.Y and Suresh Kumar, G* (2016) Spectroscopic studies on the binding interaction of phenothiazinium dyes, azure A and azure B to
    double stranded RNA polynucleotides. Spectrochim. Acta Part A 152, 417-425.
  24. Khan, A.Y, and Suresh Kumar, G* (2015) A thermodynamic investigation on the binding of phenothiazinium dyes azure A and azure B to double stranded RNA polynucleotides. J. Chem. Thermodyn. 91, 225–233.
  25. Jash, C, Basu, P, Payghan, P.V. Ghoshal, N and Suresh Kumar, G* (2015) Structural and thermodynamic studies on the interaction of iminium and alkanolamine forms of benzophenanthridine alkaloid chelerythrine with lysozyme. Phys. Chem. Chem. Phys. 17, 16630-16645.
  26. Basu, P and Suresh Kumar, G* (2015) Structural and thermodynamic basis of interaction of the putative anticancer agent chelerythrine with single, double and triple-stranded RNAs. RSC Adv. 5, 29953-29964.
  27. Basu, A and Suresh Kumar, G* (2015) The food colorant carmoisine can bind strongly to hemoglobin: Spectroscopic and calorimetric characterization. Food Res. Int. 72, 54-61.
  28. Basu, A and Suresh Kumar, G* (2015) Thermodynamic characterization of proflavine-DNA binding through microcalorimetric stuides. J. Chem. Thermodyn. 87, 1-7.
  29. Basu, A and Suresh Kumar, G* (2015) Interaction of toxic azo dyes with heme proteins: Biophysical insights into the binding aspects of the food additive amaranth with human hemoglobin. J. Hazard. Mater. 289, 204-209.
  30. Ghosh, S, Chakrabarty, S, Bhowmik, D, Suresh Kumar, G and Chattopadhyay, N (2015) Step-wise deformation of bovine and human serum albumin by an anionic surfactant: An investigation using proton transfer probe norharmane. J. Phys. Chem. B 119, 2090-2102.
  31. Basu, A and Suresh Kumar, G* (2015) Thermodynamics of the interaction of the food additive tartrazine with serum albumins: A microcalorimetric investigation. Food Chem. 175, 137-142.
  32. Hazra, S and Suresh Kumar, G* (2015) Physicochemical properties of inclusion complexes of sanguinarine with natural cyclodextrins: Spectroscopy, calorimetry and NMR studies. RSC Adv. 5, 1873–1882.
  33. Suresh Kumar, G* (2015) Isoquinoline alkaloids and their analogs: Nucleic acid and protein binding aspects and therapeutic potential for drug design, in Bioactive Natural Products: Chemistry & Biology, WILEY-VCH Verlag GmbH & Co. KGaA, 2015, pp. 241-277.
  34. 155. Basu, P and Suresh Kumar, G* (2015) Entropy driven binding of the putative anticancer plant alkaloid chelerythrine to polyadenylic acid leads to spontaneous self-structure formation. J. Chem. Thermodyn. 81, 116-123.
  35. Jash, C, Payghan, P.V. Ghoshal, N and Suresh Kumar, G* (2014) Binding of the iminium and alkanolamine forms of sanguinarine to lysozyme: Spectroscopic analysis, thermodynamics and molecular modeling studies. J. Phys. Chem. B 118(46),13077–13091.
  36. Kabir, A and Suresh Kumar, G* (2014) Targeting of double stranded RNA with spermine, 1-naphthyl acetyl spermine and spermidine: A comparative biophysical investigation. J. Phys. Chem. B 118(38),11050-11064.
  37. Samanta, N, Mahanta, D.D, Hazra, S, Suresh Kumar, G* and Mitra, R (2014) Short chain polyethylene glycols unusually assist thermal unfolding of Human serum albumin.  Biochimie 104, 81-89.
  38. Hazra, S and Suresh Kumar, G* (2014) Structural and thermodynamic studies on the interaction of iminium and alkanolamine forms of sanguinarine with hemoglobin. J. Phys. Chem. B 118(14), 3771-3784.
  39. Kabir, A and Suresh Kumar G* (2014) Probing the interaction of spermine and 1-naphthyl acetyl spermine with DNA polynucleotides: A comparative biophysical and thermodynamic investigation. Mol. BioSyst. 10, 1172-1183.
  40. Patra, A, Hazra, S and Suresh Kumar, G* and Mitra, R (2014) Entropy contribution towards micelle driven de-intercalation of drug-DNA complex. J. Phys. Chem. B 118(4), 901–908.
  41. Hazra, S, Hossain, M and Suresh Kumar, G*  (2013) Binding of isoquinoline alkaloids berberine, palmatine, and coralyne to hemoglobin. Structural and thermodynamic characterization studies. Mol. BioSyst.9,143-153.
  42. Das, A and Suresh Kumar, G* (2013) Binding of the plant alkaloid aristololactam-β-D-glucoside and  antitumor antibiotic daunomycin to single stranded polyribonucleotides. Biochim. Biophys. Acta.1830, 4708-4718.
  43. Devi, P.S, Banerjee, S. Roy Chowdhury, S and Suresh Kumar, G* (2012) Eggshell membrane:  a natural biotemplate to synthesize fluorescene gold nanoparticles. RSC Adv.2, 11578-11585.
  44. Bhaumik, D, Hossain, M, Buzzetti, F, D’Auria, R, Lombardi, P and Suresh Kumar, G* (2012) Biophysical studies on the effect of the 13 position substitution of the anticancer alkaloid berberine on Its DNA binding. J. Phys. Chem. B 116, 2314-2324.
  45. Bhadra, K and Suresh Kumar, G* (2011) Therapeutic potential of nucleic acid binding isoquinoline alkaloids:  Binding aspects and implications for drug design. Med. Res. Rev. 31(6), 821-862.
  46. Saha, I, Hossain, M and Suresh Kumar, G* (2010) Sequence selective binding of phenazinium dyes, phenosafranin and safranin O to guanine-cytosine deoxyribopolynucleotides: Spectroscopic and thermodynamic studies. J.Phys. Chem. B.114(46), 15278–15287.
  47. Saha, I, Hossain M and Suresh Kumar, G* (2010) Base pair specificity and energetics of binding of phenazinium molecules phenosafranin and safranin-O to deoxyribonucleic acids: A comparative study. Phys. Chem. Chem. Phys. 12,12771-12779.
  48. Roy Chowdhury, S, Islam M. M and Suresh Kumar, G* (2010) Binding of the benzophenanthridine alkaloid sanguinarine to double stranded RNA polynucleotides: New insights into the structural aspects and energetics of interaction. Mol. BioSyst. 6, 1265-1276.
  49. Giri, P and Suresh Kumar, G* (2010) Molecular recognition of poly(A) by protoberberine alkaloids: In vitro biophysical studies and biological perspectives. Mol. Biosyst. 6, 81-88.
  50. Hossain, M and Suresh Kumar, G*(2009) DNA intercalation of methylene blue and quinacrine: New insights into base and sequence specificity from structural and thermodynamic studies with polynucleotides. Mol. Biosyst. 5, 1311-1322.
  51. Sinha, R and Suresh Kumar, G* (2009) Interaction of isoquinoline alkaloids with RNA triplex: Structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)*poly(U). J. Phys. Chem. B 113,13410-13420.
  52. Giri, P and Suresh Kumar, G* (2009) Molecular aspects of small molecule-poly(A) interaction: An approach to RNA based drug design. Curr. Med. Chem. 16, 965-987.
  53. Islam. M.M. Pandya, P, Kumar, S and Suresh Kumar, G* (2009) RNA targeting through small molecule binding: Studies on t-RNA binding by cytotoxic protoberberine alkaloid coralyne. Mol. Biosyst. 5, 244-254. (cover page article)
  54. Islam, M. M, Roy Chowdhury, S and Suresh Kumar, G* (2009) Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double-stranded RNA polynucleotides. J. Phys. Chem. B 113, 1210-1224.
  55. Suresh Kumar, G, Lipman, R, Cummings, J and Tomasz, M (1997) Mitomycin C adducts generated by DT-Diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C, Biochemistry 36, 14128-14136.
  56. Suresh Kumar, G, Musser, S. M, Cummings, J and Tomasz, M (1996). 2, 7-Diaminomitosene, a monofunctonal mitomycin C derivative alkylates DNA in the major groove. Structure and base sequence specificity of the DNA adduct and mechanism of alkylation, J. Am. Chem. Soc. 118, 9209-9217.
 
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