Chemistry Division

Dr. G. Suresh Kumar

PhD, University of Delhi, 1987
Postdoctoral Research
City University of New York- Hunter College, New York, USA
(1993-1995 and 1999-2001)

Contact - gskumar@iicb.res.in / gsk.iicb@gmail.com


Senior Principal Scientist

Current Research Interest

  1. Micro RNA-mRNA interaction.
  2. DNA and RNA polymorphism.
  3. Interaction of Drugs with DNA and RNA: Molecular basis of the antitumor action of alkaloids through biophysical studies.
  4. Binding of a number of medically important natural products and small molecules to polymorphic nucleic acid structures like duplex, triplex and quadruplexes.
  5. Photochemistry and photobiology of alkaloids.

Names of the group members including regular staff with designation and research fellows

Fellow / RA / PA

  1. Dr. Jhimli Bhattacharyya, Research Associate (CSIR), E mail:  Jhimli.bhattacharyya@gmail.com
  2. Ms. Abhi Das, SRF, CSIR,  E Mail: abhi.das8310@yahoo.co.in
  3. Ms. Puja Paul, SRF, CSIR, E Mail: pujapaul@yahoo.co.in
  4.  Mr. Anirban Basu, SRF, UGC, E Mail: basu.ani.anirban@gmail.com  
  5. Ms. Asma Yasmeen Khan, SRF, UGC, E Mail: asmayasmeenkhan@gmail.com
  6. Ms. Ayesha Kabir, SRF, CSIR,  E Mail: ayesha.kabir10@gmail.com
  7. Ms. Debipreeta Bhowmik, SRF, UGC, E.Mail: debipreetabhowmik@gmail.com
  8. Mr. Soumitra Hazra, SRF, CSIR, Email: soumitrahazra88@gmail.com
  9. Ms. Chandrima Jash, JRF, Inspire, Email: cjash2009@gmail.com
  10. Ms. Pritha Basu, JRF, UGC, Email: titli.prithabasu1988@gmail.com
  11. Ms. Baishaki Saha, JRF, UGC, Email: baishakhi.saha10@gmail.com

List of important Publications

  1. Das, A, Bhadra, K and Suresh Kumar, G*. (2011) Targeting RNA by small molecules: Comparative structural and thermodynamic aspects of aristololactam-β-d-glucoside and daunomycin binding to tRNAphe, PLoS One (in press).
  2. Bhadra, K and Suresh Kumar, G*. (2011) Therapeutic potential of nucleic acid binding isoquinoline alkaloids:  Binding aspects and implications for drug design. Med. Res. Rev. (in press) doi:10.1002/med.20202.
  3. Hossain, M, Khan A. Y, and Suresh Kumar, G*. (2011) Interaction of the plant alkaloid sanguinarine with bovine serum albumin. PLos One 6(4): e18333
  4. Saha, I, Hossain, M and Suresh Kumar, G* (2010) Sequence selective binding of phenazinium dyes, phenosafranin and safranin O to guanine-cytosine deoxyribopolynucleotides: Spectroscopic and thermodynamic studies. J.Phys. Chem. B.114(46), 15278–15287.
  5. Paul, P and Suresh Kumar, G*. (2010) Toxic interaction of thionine to deoxyribonucleic acids: Elucidation of the sequence specificity of binding to polynucleotides. J. Hazard.  Mater. 184, 620-6226.
  6. Saha, I, Hossain M and Suresh Kumar, G*. (2010) Base pair specificity and energetics of binding of phenazinium molecules phenosafranin and safranin-O to deoxyribonucleic acids: A comparative study. Phys. Chem. Chem. Phys. 12,12771-12779.
  7. Roy Chowdhury, S, Islam M. M and Suresh Kumar, G*, (2010) Binding of the benzophenanthridine alkaloid sanguinarine to double stranded RNA polynucleotides: New insights into the structural aspects and energetics of interaction. Mol. BioSystems 6, 1265-1276.
  8. Giri, P and Suresh Kumar, G. (2010) Molecular recognition of poly(A) by protoberberine alkaloids: In vitro biophysical studies and biological perspectives. Mol. Biosystems 6, 81-88.
  9. Hossain, M and Suresh Kumar, G*. (2009) DNA intercalation of methylene blue and quinacrine: New insights into base and sequence specificity from structural and thermodynamic studies with polynucleotides. Mol. Biosystems 5, 1311-1322.
  10. Sinha, R and Suresh Kumar, G*. (2009) Interaction of isoquinoline alkaloids with RNA triplex: Structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)*poly(U). J. Phys. Chem. B 113,13410-13420.
  11. Giri, P and Suresh Kumar, G*. (2009) Molecular aspects of small molecule-poly(A) interaction: An approach to RNA based drug design. Curr. Med. Chem. 16, 965-987.
  12. Islam. M.M. Pandya, P, Kumar, S and Suresh Kumar, G*. (2009) RNA targeting through small molecule binding: Studies on t-RNA binding by cytotoxic protoberberine alkaloid coralyne. Mol. Biosystems 5, 244-254.
  13. Islam, M. M, Roy Chowdhury, S and Suresh Kumar, G*. (2009) Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double-stranded RNA polynucleotides. J. Phys. Chem. B 113, 1210-1224.
  14. Suresh Kumar, G, Lipman, R, Cummings, J and Tomasz, M. (1997) Mitomycin C adducts generated by DT-Diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C, Biochemistry 36, 14128-14136.
  15. Suresh Kumar, G, Musser, S. M, Cummings, J and Tomasz, M. (1996). 2, 7-Diaminomitosene, a monofunctonal mitomycin C derivative alkylates DNA in the major groove. Structure and base sequence specificity of the DNA adduct and mechanism of alkylation, J. Am. Chem. Soc. 118, 9209-9217.
 
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Updated on 14th Sep 2013


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