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Chemistry Division

Dr. G. Suresh Kumar
Senior Principal Scientist

PhD, University of Delhi, 1987
Contact - gskumar@iicb.res.in / gsk.iicb@gmail.com

Postdoctoral Research
City University of New York- Hunter College, New York, USA (1993-1995 and 1999-2001)

Current Research Interest

  • Micro RNA-mRNA interaction.
  • DNA and RNA polymorphism.
  • Interaction of Drugs with DNA and RNA: Molecular basis of the antitumor action of alkaloids through biophysical studies.
  • Binding of a number of medically important natural products and small molecules to polymorphic nucleic acid structures like duplex, triplex and quadruplexes.
  • Photochemistry and photobiology of alkaloids.
 
Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff
  1. Dr. Maidul Hossain, Research Associate, E Mail: maidulhossain@iicb.res.in 
  2. Dr. Jhimli Bhattacharyya, Project Associate, E mail:  Jhimli.bhattacharyya@gmail.com
  3. Ms. Ishita Saha, SRF, CSIR, E Mail: rakhi2684@gmail.com 
  4. Ms. Abhi Das, SRF, CSIR,  E Mail: abhi.das8310@yahoo.co.in
  5. Ms. Puja Paul, JRF, CSIR, E Mail: pujapaul@yahoo.co.in
  6. Ms. Ayesha Kabir, JRF, CSIR,  E Mail: ayesha.kabir10@gmail.com 
  7. Mr. Anirban Basu, JRF, UGC, E Mail: basu.ani.anirban@gmail.com  
  8. Ms. Asma Yasmeen Khan, JRF, UGC, E Mail: asmayasmeenkhan@gmail.com
  9. Ms. Debipreeta Bhowmik, JRF, UGC, E.Mail: debipreeta_ju@yahoo.co.in
  10. Mr. Soumitra Hazra, JRF, CSIR, Email: soumitrahazra88@gmail.com
 

List of important Publications:

  1. Das, A, Bhadra, K and Suresh Kumar, G*. (2011) Targeting RNA by small molecules: Comparative structural and thermodynamic aspects of aristololactam-β-d-glucoside and daunomycin binding to tRNAphe, PLoS One (in press).
  2. Bhadra, K and Suresh Kumar, G*. (2011) Therapeutic potential of nucleic acid binding isoquinoline alkaloids:  Binding aspects and implications for drug design. Med. Res. Rev. (in press) doi:10.1002/med.20202.
  3. Hossain, M, Khan A. Y, and Suresh Kumar, G*. (2011) Interaction of the plant alkaloid sanguinarine with bovine serum albumin. PLos One 6(4): e18333
  4. Saha, I, Hossain, M and Suresh Kumar, G* (2010) Sequence selective binding of phenazinium dyes, phenosafranin and safranin O to guanine-cytosine deoxyribopolynucleotides: Spectroscopic and thermodynamic studies. J.Phys. Chem. B.114(46), 15278–15287.
  5. Paul, P and Suresh Kumar, G*. (2010) Toxic interaction of thionine to deoxyribonucleic acids: Elucidation of the sequence specificity of binding to polynucleotides. J. Hazard.  Mater. 184, 620-6226.
  6. Saha, I, Hossain M and Suresh Kumar, G*. (2010) Base pair specificity and energetics of binding of phenazinium molecules phenosafranin and safranin-O to deoxyribonucleic acids: A comparative study. Phys. Chem. Chem. Phys. 12,12771-12779.
  7. Roy Chowdhury, S, Islam M. M and Suresh Kumar, G*, (2010) Binding of the benzophenanthridine alkaloid sanguinarine to double stranded RNA polynucleotides: New insights into the structural aspects and energetics of interaction. Mol. BioSystems 6, 1265-1276.
  8. Giri, P and Suresh Kumar, G. (2010) Molecular recognition of poly(A) by protoberberine alkaloids: In vitro biophysical studies and biological perspectives. Mol. Biosystems 6, 81-88.
  9. Hossain, M and Suresh Kumar, G*. (2009) DNA intercalation of methylene blue and quinacrine: New insights into base and sequence specificity from structural and thermodynamic studies with polynucleotides. Mol. Biosystems 5, 1311-1322.
  10. Sinha, R and Suresh Kumar, G*. (2009) Interaction of isoquinoline alkaloids with RNA triplex: Structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)*poly(U). J. Phys. Chem. B 113,13410-13420.
  11. Giri, P and Suresh Kumar, G*. (2009) Molecular aspects of small molecule-poly(A) interaction: An approach to RNA based drug design. Curr. Med. Chem. 16, 965-987.
  12. Islam. M.M. Pandya, P, Kumar, S and Suresh Kumar, G*. (2009) RNA targeting through small molecule binding: Studies on t-RNA binding by cytotoxic protoberberine alkaloid coralyne. Mol. Biosystems 5, 244-254.
  13. Islam, M. M, Roy Chowdhury, S and Suresh Kumar, G*. (2009) Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double-stranded RNA polynucleotides. J. Phys. Chem. B 113, 1210-1224.
  14. Suresh Kumar, G, Lipman, R, Cummings, J and Tomasz, M. (1997) Mitomycin C adducts generated by DT-Diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C, Biochemistry 36, 14128-14136.
  15. Suresh Kumar, G, Musser, S. M, Cummings, J and Tomasz, M. (1996). 2, 7-Diaminomitosene, a monofunctonal mitomycin C derivative alkylates DNA in the major groove. Structure and base sequence specificity of the DNA adduct and mechanism of alkylation, J. Am. Chem. Soc. 118, 9209-9217.

Detail list of Publications upto September'2012 ==>> Click here

 

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Updated on 16th October'2012

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