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Dr. Sumantra Das
Chief Scientist & Head
PhD, Calcutta University
Contact - sdas@iicb.res.in |
Current Research Interest
About 30 years of research experience in the field of neurobiochemistry and neuropharmacology.
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structure and function of developing astrocytes: studies using different developmental regulators of astroglial cells like thyroid hormones, b-adrenergic agonists and poly unsaturated fatty acids in primary cultures.
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newer approaches for the treatment of narcotic addiction: a) designing of novel anti-addictive alkaloids and b) predictive medicine strategies.
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biochemistry of limbal cells and its transplantation in ocular surface disorders.
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Research fellows:
Mr. Deepak Kumar |
Ms. Anindita Chakraborty
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Staff:
Mr. P. C. Deuri |
Ms. Ayantika Pal
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Mr. Tuhin S. Banerjee
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Ms. Moitreyi Das
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Some recent publications:
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K. Gharami and Sumantra Das (2004): Delayed but sustained induction of mitogen-activated protein kinase activity is associated with b-adrenergic receptor-mediated morphological differentiation of astrocytes. J. Neurochemistry 88, 12-22.
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M. Ghosh, K. Gharami, S. Paul and Sumantra Das (2005): Thyroid-hormone induced morphological differentiation and maturation of astrocytes involves activation of protein kinase A and ERK signaling pathway. Eur. J. Neurosci. 22, 1609-1617.
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Member of the The Indian Genome Variation Consortium (2005): The Indian Genome Variation database (IGVdb): a project overview. Human Genetics 118, 1-11.
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A. Joardar, A. K. Sen and Sumantra Das (2006): Docosahexaenoic acid facilitates cell maturation and beta adrenergic transmission in astrocytes. J. Lipid Research 47, 571-581.
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A. Joardar A and Sumantra Das (2007): Effect of fatty acids isolated from edible oils like mustard, linseed or coconut on astrocytes maturation. Cell. Molec. Neurobiol. 27, 973-983.
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A. Dasgupta, Sumantra Das and P.K. Sarkar (2007): Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Free Radic. Biol. Med. 42, 617-626.
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J. Naskar, M.G. Drew, I. Deb, Sumantra Das and A. Banerjee (2008): Water-soluble tripeptide Ab(9-11) forms amyloid-like fibrils and exhibits neurotoxicity. Organic Lett. 10, 2625-2628.
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A. Chinnakkaruppan, Sumantra Das and P.K. Sarkar (2009): Age related and hypothyroidism related changes on the stoichiometry of neurofilament subunits in the developing rat brain. Int. J. Devl Neurosci. 27, 257–261.
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I. Deb, P. Paira, A. Hazra, S. Banerjee, P.K. Dutta, N.B. Mondal and Sumantra Das (2009): Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the k and m receptors: Potential therapeutic efficacy against morphine dependence. Bioorg. & Med. Chem. 17, 5782–5790.
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I. Deb, J. Chakraborty, P.K.Gangopadhyay, S.Roy Chowdhury and Sumantra Das (2009): Single-nucleotide polymorphism(A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. J.Neurochem. 112, 486-496.
Detail list of Publications upto December'2010 ==>> Click here
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