Cell Biology & Physiology Division

Dr. Sumantra Das

PhD, Calcutta University

Contact - sdas@iicb.res.in


Chief Scientist & Head

 

Current Research Interest

About 30 years of research experience in the field of neurobiochemistry and neuropharmacology.

  • structure and function of developing astrocytes: studies using different developmental regulators of astroglial cells like thyroid hormones, b-adrenergic agonists and poly unsaturated fatty acids in primary cultures.
  • newer approaches for the treatment of narcotic addiction: a) designing of novel anti-addictive alkaloids and b) predictive medicine strategies.
  • biochemistry of limbal cells and its transplantation in ocular surface disorders.

 

Names of the group members including regular staff with designation and research fellows

Staff Member`s

Mr. P. C. Deuri http://www.iicb.res.in/divisionwiselistofscientists/cbp/imgs/sumantra_das/deuri_pc.jpg

Research Fellows

Mr. Deepak Kumar
Ms. Anindita Chakraborty http://www.iicb.res.in/divisionwiselistofscientists/cbp/imgs/sumantra_das/anindita.jpg
Ms. Ayantika Pal http://www.iicb.res.in/divisionwiselistofscientists/cbp/imgs/sumantra_das/ayantika.jpg
Mr. Tuhin S. Banerjee http://www.iicb.res.in/divisionwiselistofscientists/cbp/imgs/sumantra_das/tuhin.jpg
Ms. Moitreyi Das http://www.iicb.res.in/divisionwiselistofscientists/cbp/imgs/sumantra_das/moitreyi.jpg

List of important Publications

  1. K. Gharami and Sumantra Das (2004): Delayed but sustained induction of mitogen-activated protein kinase activity is associated with b-adrenergic receptor-mediated morphological differentiation of astrocytes. J. Neurochemistry 88, 12-22.
  2. M. Ghosh, K. Gharami, S. Paul and Sumantra Das (2005): Thyroid-hormone induced morphological differentiation and maturation of astrocytes involves activation of protein kinase A and ERK signaling pathway. Eur. J. Neurosci. 22, 1609-1617.
  3. Member of the The Indian Genome Variation Consortium (2005): The Indian Genome Variation database (IGVdb): a project overview.  Human Genetics 118, 1-11.
  4. A. Joardar, A. K. Sen and Sumantra Das (2006): Docosahexaenoic acid facilitates cell maturation and beta adrenergic transmission in astrocytes. J. Lipid Research 47, 571-581.
  5. A. Joardar A and Sumantra Das (2007): Effect of fatty acids isolated from edible oils like mustard, linseed or coconut on astrocytes maturation. Cell. Molec. Neurobiol. 27, 973-983.
  6. A. Dasgupta, Sumantra Das and P.K. Sarkar (2007): Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Free Radic. Biol. Med. 42, 617-626.
  7. J. Naskar,  M.G. Drew, I. Deb, Sumantra Das  and A. Banerjee (2008): Water-soluble tripeptide Ab(9-11) forms amyloid-like fibrils and exhibits neurotoxicity. Organic Lett. 10, 2625-2628.
  8. A. Chinnakkaruppan, Sumantra Das and P.K. Sarkar (2009): Age related and hypothyroidism related changes on the stoichiometry of neurofilament subunits in the developing rat brain. Int. J. Devl Neurosci. 27, 257–261.
  9. I. Deb, P. Paira, A. Hazra, S. Banerjee, P.K. Dutta, N.B. Mondal and Sumantra Das (2009): Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the k and m receptors: Potential therapeutic efficacy against morphine dependence.  Bioorg. & Med. Chem. 17, 5782–5790.
  10. I. Deb, J. Chakraborty, P.K.Gangopadhyay, S.Roy Chowdhury and Sumantra Das (2009): Single-nucleotide polymorphism(A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. J.Neurochem. 112, 486-496.
 
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Updated on 14th May 2010


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