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Cell Biology & Physiology Division

Dr. Sib Sankar Roy

Principal Scientist,
Metabolic Disorder Laboratory
PhD, Bose Institute, Kolkata
Post Doc: Harvard School of Public Health, Boston.
Contact: sibsankar@iicb.res.in / sibsankar1967@gmail.com

Current Research Interest

A) Understanding the molecular mechanisms associated with ovarian cancer.

  • Interplay and cross-talks among different factors and pathways in ovarian cancer.
  • Role of the signaling network and the transcription factors regulating MMPs responsible for invasion, migration and metastasis in ovarian carcinoma.
  • Study of different factors and/or signaling pathways inducing EMT.
  • Investigating the role of different genes in ovarian disorders with emphasis on collagen metabolism.

B) Investigation on molecular mechanisms behind the insulin resistance and diabetes type 2 (T2DM)

  • The molecular mechanism of fatty acid induced insulin resistance is being investigated.
  • The role of mitochondrial dysfunction in diabetes is being investigated in suitable model.
  • Role of oxidative stress in the pathogenesis of T2DM
  • Identifying pharmacological agents and their mode of action in improving FFA induced insulin resistance.

C) To study the role of Homeodomain Transcription factors in diseases:

  • The role of homeodomain transcription factor, Pitx2, in maintaining ovarian structure and function is under investigation.
  • The involvement of Pitx2 in promoting ovarian cancer through the activation of growth factor gene and /or signaling pathways are being investigated.
Names of the group members including regular staff with designation and research fellows:
Fellow/RA/PA Staff
  1. Mr. Shyam Sundar Nandi, SRF
  2. Mr. Sudarshan Bhattacharya, SRF
  3. Ms. Moitri Basu, SRF
  4. Ms. Nabanita Das, JRF
  5. Ms. Shreya Roy Chowdhury, Project Fellow
  6. Ms. Upasana Ray, JRF
  7. Ms. Tulika Mitra, JRF
  8. Mr. Ashok Mandala, JRF
  9. Mr. Rahul Bhattacharya, JRF
  10. Mr Swapan Mandal, Technical Officer
  11. Mr. Prabir Kumar Dey, Project Asst.

 

 

List of important Publications:

  1. Moitri Basu and Sib Sankar Roy* (2013) Wnt/β-Catenin Pathway Is Regulated by PITX2 Homeodomain Protein and Thus Contributes to the Proliferation of Human Ovarian Adenocarcinoma Cell, SKOV-3. J Biol Chem 288:4355-4367.
  2. Sonali Ghosh, Moitri Basu and Sib Sankar Roy* (2012) ETS-1 Regulates Vascular Endothelial Growth Factor-induced Matrix Metalloproteinase-9 and Matrix Metalloproteinase-13 Expression in Human Ovarian Carcinoma Cell SKOV-3. J Biol Chem 287:15001-15015.
  3. Shyam Sundar Nandi, Pamela Ghosh and Sib Sankar Roy* (2011): Expression of PITX2 Homeodomain Transcription Factor during Rat Gonadal Development in a Sexually Dimorphic Manner. Cell Physiol Biochem 27:159-170.
  4. Biswas A, Bhattacharya S, Dasgupta S, Kundu R, Roy SS, Pal BC, Bhattacharya S (2010): Insulin resistance due to lipid-induced signalling defects could be prevented by mahanine. Mol Cell Biochem 336:97-107.
  5. Barma P, Bhattacharya S, Bhattacharya A, Kundu R, Dasgupta S, Biswas A, Bhattacharya S, Roy SS, Bhattacharya S (2009): Lipid induced overexpression of NF-kappaB in skeletal muscle cells is linked to insulin resistance. Biochim Biophys Acta 1792:190-200.
  6. Pamela Ghosh, Samir Kumar Saha, Shyam Sundar Nandi, Samir Bhattacharya  and Sib Sankar Roy* (2007): Involvement of Pitx2, a homeodomain transcription factor, in hypothyroidism associated reproductive disorders. Cell Physiol Biochem 20:887-898.
  7. Ghosh P, Saha SK, Bhattacharya S, Bhattacharya S, Mukherjee S, Roy * (2007): Tachykinin family genes and their receptors are differentially expressed in the hypothyroid ovary and pituitary. Cell Physiol Biochem 20:357-368.
  8. Samir Kumar Saha, Pamela Ghosh, Debanjali Mitra, Satinath Mukherjee, Samir Bhattacharya and Sib Sankar Roy* (2007) Localization and thyroid hormone influenced expression of collagen II in ovarian tissue. Cell Physiol Biochem 19:67-76.
  9. Dey D, Pal BC, Biswas T, Roy SS, Bandyopadhyay A, Mandal SK, Giri BB and Bhattacharya S (2007) A Lupinoside prevented fatty acid induced inhibition of insulin sensitivity in 3T3 L1 adipocytes. Mol Cell Biochem 300(1-2):149-57.
  10. Samir Kumar Saha, Pamela Ghosh, Samir Bhattacharya and Sib Sankar Roy* (2007) Procollagen synthesis is increased in hypothyroid rat ovary by a parallel and compensatory pathway. Cell Physiology Biochem 19:313-322.
  11. Debleena Dey, Anirban Bhattacharya, Sib Sankar Roy and Samir Bhattacharya (2007) Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Ce. Biochem Biophys Res Commun 357: 474-479.
  12. Ghosh P, Saha SK, Bhattacharya S, Bhattacharya S, Mukherjee S, Roy SS* (2007): Tachykinin family genes and their receptors are differentially expressed in the hypothyroid ovary and pituitary. Cell Physiol Biochem 20:357-368.
  13. Dey D, Basu D, Roy SS, Bandyopadhyay A and Bhattacharya S (2006). Involvement of novel PKC isoforms in FFA induced defects in insulin signaling. Mol Cell Endocrinol. 246(1-2):60-4.
  14. Samir kumar Saha, Pamela Ghosh, Aditya Konar, Samir Bhattacharya and Sib Sankar Roy* (2005) Differential expression of Procollagen Lysine 2-Oxoglutarate 5-Deoxygenase and Matrix Metalloproteinase Isoforms in Hypothyroid Rat Ovary and Disintegration of Extracellular Matrix. Endocrinology 146(7): 2963-2975.
  15. Debleena Dey, Mohua Mukherjee, Dipanjan Basu, Malabika Datta, Sib Sankar Roy, Arun Bandyopadhyay and Samir Bhattacharya (2005). Inhibition of Insulin Receptor Gene Expression and Insulin Signalling by Fatty Acid: Interplay of PKC Isoforms Therein. Cellular Physiology and Biochemistry; 16:217-228.
  16. Sib Sankar Roy, Mohua Mukherjee, Samir Bhattacharya, C. N. Mandal, L. Ravi Kumar, Subrata Dasgupta, I. Bandyopadhyay, Katsumi Wakabayashi. (2003)  A New Cell Secreting Insulin. Endocrinology 144(4):1585-1593.
  17. Datta, M., Nagendra Prasad, R. J., Navneet, A. K., Roy, S. S. and Bhattacharya, S. (2002) Thyroid Hormone-induced protein (TIP) gene expression by 3,5,3’-triiodothyronine in the ovarian follicle o perch (Anabas testudineus, Bloch): modulation of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase enzyme by TIP. Gen. Comp. Endocrionol 126, 334-341.

Detail list of Publications upto March 2013 ==>> Click here

 

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Updated on 8th April 2013
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