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Cell Biology & Physiology Division

Dr. Subhas C. Biswas

Senior Scientist

Ph.D. (1998), Jadavpur University, Kolkata, India
Post Doctoral Research (1998 – 2009), Columbia University, New York, USA

Contact - subhasbiswas@iicb.res.in / biswassc@gmail.com

Current Research Interest

Neurodegenerative diseases: Identification of molecular targets for therapeutic intervention. Neuronal loss by apoptosis is one of the pathological hallmarks of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. However, the molecular events, particularly those that initiate death of neurons in neurodegenerative diseases are incompletely understood. Identification of molecules that are elevated/activated and that are required for neurodegeneration in cellular and animal models of diseases may provide us with novel targets for blocking neuronal loss in these diseases.

Major objectives are:

  • Identification and characterization of death-associated molecules that are induced and required for neuron death in cellular and animal models of neurodegenerative diseases.
  • Transcriptional regulation of death-associated genes during neuronal apoptosis.
  • Signalling mechanisms that regulate the level and/or activity of death-associated molecules.

Names of the group members including regular staff with designation and research fellows:
JRF/SRF/RA Project Assistants
  1. Ms. Nandini Chatterjee (JRF,CSIR)
  2. Ms. Rumana Akhter (JRF, CSIR)
  3. Mr.Priyankar Sanphui (JRF, CSIR)
  4. Ms.Pampa Saha (JRF, CSIR)
  5. Ms.Suraiya Saleem (JRF, CSIR)

 

 

List of important Publications:

  1. Biswas, S. C., Buteau, J., and Greene, L.A. (2008). Glucagon-like peptide-1 (GLP-1) diminishes neuronal degeneration and death caused by NGF deprivation by suppressing Bim induction. Neurochem Res 33(9):1845-1851.
  2. Biswas, S. C., Shi, Y., Sproul, A. A. and Greene, L.A. (2007). Pro-apoptotic Bim induction in response to NGF deprivation requires simultaneous activation of three different death signaling pathways. J Biol Chem  282(40):29368-29374.
  3. Biswas, S. C., Shi, Y., Vonsattel, J. G., Leung, C.L., Troy, C.M. and Greene, L.A. (2007). Bim is elevated in Alzheimer disease neurons and is required for beta- amyloid induced neuronal apoptosis. J Neurosci 27(4):893-900.
  4. Greene, L.A., Liu, D. X., Troy, C.M. and Biswas, S. C. (2007). Cell Cycle Molecules Define A Pathway Required For Neuron Death In Development And Disease. Biochim Biophys Acta 1772(4):392-401.
  5. Malagelada, C., Ryu, E., Biswas, S. C., Verince, J. L. and Greene, L.A. (2006). RTP801 is selectively elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson disease. J Neurosci 26(39): 9996-10005.
  6. Biswas, S. C., Liu, D. X. and Greene, L. A. (2005). Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J Neurosci 25(37): 8349-8358.
  7. Biswas, S. C., Ryu, E., Park, C., Malagelada, C., and Greene, L. A. (2005). PUMA and p53 play required roles in death evoked in a cellular model of Parkinson disease Neurochem Res 30(6/7): 839-845.
  8. Liu, D.X., Biswas, S.C. and Greene, L.A. (2004). B-Myb and C-Myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage. J Neurosci 24(40): 8720-8725.
  9. Greene, L.A., Biswas, S.C., and Liu, D.X. (2003). Cell cycle molecules and vertebrate neuron death: E2F at the hub. Cell Death Differ 11(1): 49-60.
  10. Biswas, S.C., and Greene, L.A. (2002). NGF down-regulates the BH3-only protein BIM and    suppresses its pro-apoptotic activity by phosphorylation. J Biol Chem 277(51): 49511-49516.
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Updated on 7th October'2011
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