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Cell Biology & Physiology Division

Dr. Subhas C. Biswas

Senior Scientist

Ph.D. (1998), Jadavpur University, Kolkata, India
Post Doctoral Research (1998 – 2009), Columbia University, New York, USA

Contact - subhasbiswas@iicb.res.in / biswassc@gmail.com

 

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Current Research Interest

Neurodegenerative diseases: Molecular basis of neurodegeneration

Neurodegneration underlies the pathology of neurological disorders such as Alzheimer’s disease and Parkinson’s disease. The molecular events that initiate death of neurons in these diseases are incompletely understood. Identification of molecules that are elevated/activated and are required for neurodegeneration in cellular and animal models of diseases may provide us with novel endogenous targets for therapeutic intervention in these diseases.

Major objectives are:

  • Aberrant cell cycle activation and neurodegeneration
  • Role and regulation of death-associated proteins during neuronal apoptosis
  • Astrogliosis and its contribution to neurodegeneration
  • Signalling mechanisms that regulate the level and/or activity of death-associated molecules
  • Development of therapeutics for neurodegenerative diseases

Names of the group members including regular staff with designation and research fellows:

JRF/SRF/RA Project Assistants
  1. Dr. Swarupa Ghosh (RA, CSIR)
  2. Ms. Nandini Chatterjee (SRF,CSIR)
  3. Ms. Rumana Akhter (SRF, CSIR)
  4. Mr. Priyankar Sanphui (SRF, CSIR)
  5. Ms. Pampa Saha (SRF, CSIR)
  6. Ms. Suraiya Saleem (SRF, CSIR)
  7. Ms. Hrishita Das (Project Fellow, CSIR)

 

 

List of important Publications:

  1. Sanphui, P., Pramanik, S.K., Chatterjee, N., Moorthi, P., Banerji, B., and Biswas, S. C. (2013). Efficacy of Cyclin dependent kinase 4 inhibitors as potent neuroprotective agents against insult relevant to Alzheimer’s disease. PloS One (In Press).
  2. Zareen, N. Biswas, S. C. Greene, L.A. (2013). A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons. Cell Death Differ (In Press).
  3. Sanphui, P., Biswas, S. C. (2013). FoxO3a is activated and executes neuron death via Bim in response to beta-amyloid. Cell Death Dis 4:e625. 
  4. Banerji B., Pramanik S. K., Sanphui P.,  Nikhara S., and Biswas S. C. (2013) Synthesis and Cytotoxicity Studies of Novel Triazolo-benzoazulenes as new Anticancer Agents. Chem Biol Drug Des82: 401–409.
  5. Biswas, S. C., Zhang, Y., Iyirhiaro, G., Willett, R.T., Rodriguez Gonzalez, Y., Cregan, S.P., Slack, R.S., Park, D.S., Greene, L.A. (2010). Sertad1 plays an essential role in developmentaland and pathological neuron death. J Neurosci 30(11):3973-3982.
  6. Biswas, S. C., Shi, Y., Sproul, A. A. and Greene, L.A. (2007). Pro-apoptotic Bim induction in response to NGF deprivation requires simultaneous activation of three different death signaling pathways. J Biol Chem 282(40):29368-29374.
  7. Biswas, S. C., Shi, Y., Vonsattel, J. G., Leung, C.L., Troy, C.M. and Greene, L.A. (2007). Bim is elevated in Alzheimer disease neurons and is required for beta- amyloid induced neuronal apoptosis. J Neurosci 27(4):893-900.
  8. Greene, L.A., Liu, D. X., Troy, C.M. and Biswas, S. C. (2007). Cell Cycle Molecules Define A Pathway Required For Neuron Death In Development And Disease. Biochim Biophys Acta 1772(4):392-401.
  9. Malagelada, C., Ryu, E., Biswas, S. C., Verince, J. L. and Greene, L.A. (2006). RTP801 is selectively elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson disease. J Neurosci 26(39): 9996-10005.
  10. Biswas, S. C., Liu, D. X. and Greene, L. A. (2005). Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J Neurosci 25(37): 8349-8358.
  11. Liu, D.X., Biswas, S.C. and Greene, L.A. (2004). B-Myb and C-Myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage. J Neurosci 24(40): 8720-8725.
  12. Greene, L.A., Biswas, S.C., and Liu, D.X. (2003). Cell cycle molecules and vertebrate neuron death: E2F at the hub. Cell Death Differ 11(1): 49-60.
  13. Biswas, S.C., and Greene, L.A. (2002). NGF down-regulates the BH3-only protein BIM and suppresses its pro-apoptotic activity by phosphorylation. J Biol Chem 277(51): 49511-49516.
  14. Biswas, S.C., Dutt, A., Baker, M.W., Macagno, E.R. (2002). Association of the Receptor Protein Tyrosine Phosphatase HmLAR1 with Enabled in Hirudo medicinalis. Mol Cell Neurosci 21(4): 657-670.

 

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Updated on 23rd October'2013
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