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Cell Biology & Physiology Division

Dr. Partha Chakrabarti

Senior Scientist

* PhD, Boston University School of Medicine, USA, 2009
* MD Biochemistry, Banaras Hindu University, India, 2005
* MBBS, Calcutta Medical College, University of Calcutta, India, 2000

Contact - pc1@csiriicb.in / partha.iicb@gmail.com

Current Research Interest

Broad research area: energy metabolism; obesity; type 2 diabetes

Our lab focuses on the regulation of energy homeostasis in mammals both at the organismal and molecular levels. These include -

  1. Regulation of fat cell metabolism by hormonal signaling and nutrient sensors such as AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) complex, sirtuins (SIRT), forkhead O (FoxO) transcription factors.  
  2. Cross-talk between metabolic output and the regulation of circadian rhythm (biological clock).
  3. Identification of biological markers in Indian diabetes patients.

We hope that our work will help to understand the biology of genetic and/or molecular networks of energy metabolism and to develop new therapies for metabolic syndrome.

Names of the group members including regular staff with designation and research fellows :

Research Fellows
   
  1. Mr. Mainak Ghosh, JRF (CSIR)
  2. Ms. Dipsikha Biswas, JRF (UGC)
   

Positions will be open for individuals with NET (CSIR/UGC) fellowships to conduct research. Interested candidates may contact directly at pc1@csiriicb.in or partha.iicb@gmail.com

List of important Publications:

Research Articles

  1. Partha Chakrabarti, Taylor English, Shakun Karki, Li Qiang, Rong Tao, Juyoun Kim, Zhijun Luo, Stephen R. Farmer and Konstantin V. Kandror. SIRT1 controls lipolysis in adipocytes via FoxO1-mwdiated expression of ATGL. (2011) J Lipid Res, Jul (Epub ahead of print).
  2. Partha Chakrabarti, Taylor English, Jun Shi, Synthia M. Smas and Konstantin V. Kandror. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis and promotes fat storage. (2010)Diabetes,59: 775-781.
  3. Partha Chakrabarti and Konstantin V. Kandror. FoxO1 controls insulin-dependent ATGL expression and lipolysis in adipocytes. (2009) J. Biol. Chem. 284, 13296-13300. (Featured in Nature Lipodomics gateway http://www.lipidmaps.org/update/2009/090527/full/lipidmaps.2009.8.html)
  4. Partha Chakrabarti, Takatoshi Anno, Brendan Manning, Zhijun Luo and Konstantin V. Kandror. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid. (2008) Mol. Endocrinol. 22: 2260-2267.
  5. Ramkrishna Gupta, Partha Chakrabarti, Madhu Dikshit and Debabrata Dash. Late signaling in the activated platelets upregulates tyrosine phosphatase SHP1 and impairs platelet adhesive functions: Regulation by calcium and Src kinase. (2007) Biochim. Biophys. Acta,1773: 131-140.
  6. Partha Chakrabarti, Bimal K. Panda and Debabrata Dash. Detection of Gγ(Aγδβ)0 thalassemia in North India. (2006) Clin Chim Acta, 364: 363-364.
  7. Partha Chakrabarti, Ramkrishna Gupta, Asutosh Misra, Madhukar Rai, Vijay Pratap Singh and Debabrata Dash. Spectrum of b-thalassemia mutations in North-Indian states: a b-thalassemia trait with two mutations in cis. (2005) Clin Biochem, 38: 576-578.
  8. Partha Chakrabarti, Zubair Ahmed Karim, Ramkrishna Gupta, Vinita Vadhawan, Saikat Mukhopadhyay and Debabrata Dash. Biochemical characterization of Glanzmann’s Thrombasthenia, a rare genetic disorder affecting platelet function. (2004) Ind J Med Biochem, 8:56-60.

Review Articles

  1. Partha Chakrabarti* and Konstantin V. Kandror. Adipose Triglyceride Lipase: A New Target in the Regulation of Lipolysis by Insulin. (2011) Current Diabetes Review, 7: 270-277
  2. Partha Chakrabarti*. Promoting adipose specificity: the adiponectin promoter. (2010) Endocrinology, 151: 2408-2410 (Invited News and Views review)

* Corresponding author

   
 
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