Dr. Mrinal Kanti Ghosh

Current Research Interest

• Evaluating the role and regulation of EGFR and canonical Wnt/β-catemin signaling in cancer and stem cells.
• Understanding mechanisms of chromatin remodeling in specific gene promoters using ChIP and reChIP to counteract cancer.
• Regulation of gene expression to find novel signaling mechanism/cross-talk in glioma.

Drug development:

• Drug discovery in cancer from natural products and using target based synthetic peptides.

Names of the group members including regular staff with designation and research fellows:

1. Ms. Tapashi Mandal  (SRF,CSIR)
2. Mr. G. Kiran Kr. Naidu  (SRF,CSIR)
3. Mr. Indranil Paul (JRF,CSIR)
4. Ms. Seemana Bhattacharya (JRF,CSIR)
5. Mr.Anirban Chatterjee (JRF,CSIR)
6. Ms.Moumita Sarkar (JRF,CSIR)

1. Mr. Arijit Bhowmik (Proj. Asst - II,CSIR)
2. Mr. Syed Firoj Ahmed (Proj. Asst - II,CSIR)

List of important Publications:

1. Sha, J.*, Ghosh, M.K.*, Zhang K. and Harter, M.L. (2010). E1A interacts with two opposing pathways to induce quiescent cells into S phase. Journal of Virology (In Press). [*Equal contribution].
2. Ghosh, M.K. , Sharma, P., Harbor, P.C., Rahaman S.O., and Haque, S.J. (2005). PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene, 24 (49): 7290-300.
3. Ghosh, M.K. and Harter, M.L. (2003). A viral mechanism for remodeling chromatin structure in Go cells. Molecular Cell, 12, 255-260.
4. Ghosh, M.K., Arun, R., Chattopadhyay D.J. and Chatterjee, I.B. (2003). Cytochrome P450-mediated oxidative damage of nuclear membrane proteins and its prevention by vitamin C. Ind. J.  Biochem.  Boiphys., 40, 309-314.
5. Chattopadhyay, D., Ghosh, M.K., Mal, A. and Harter, M.L. (2001). Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. J. Virology, 75: 9844-9856.
6. Mal, A., Sturniolo, M., Schiltz, R. L., Ghosh, M.K. and Harter, M. L.  (2001). A role for histone deacetylase HDAC1 in modulating the transcriptional Activity of MyoD: Inhibition of the myogenic program. EMBO. J., 20 (7) 1739-1753.
7. Mal, A., Chattopadhyay, D., Ghosh, M.K., Poon, R. Y. C. and Harter, M. L.  (2000). p21 and Retinoblastoma protein control the absence of DNA replication in terminally differentiated muscel cells. J. Cell Biology, 149, 281-292.
8. Panda, K., Chatterjee, R., Ghosh, M.K., Chattopadhyay, D. J. and Chatterjee, I. B. (1999). Vitamin C prevents cigarette smoke induced oxidative damage of proteins and increased proteolysis. Free Rad. Biol. Med., 27, 1064-1079.
9. Ghosh, M.K., Mukhopadhyay, M. and Chatterjee, I.B. (1997). NADPH-initiated cytochrome P450-dependent free iron-independent microsomal lipid peroxidation: Specific prevention by ascorbic acid. Mol. Cell. Biochem., 166, 35-44.
10. Ghosh, M.K., Chattophadhyay, D.J. and Chatterjee, I.B.  (1996). Vitamin C prevents oxidative damage. Free Radical Research, 25, 173-179.