Cancer Biology & Inflammatory Disorder Division

Dr. Susanta Roychoudhury

PhD, Calcutta University 1985, FNASc

Contact - susanta@iicb.res.in, susantarc@gmail.com


Chief Scientist

Lab Website Link : http://srcgroup.wix.com/site

Current Research Interest

  • Genetic and epigenetic alterations of mismatch repair and spindle assembly checkpoint genes in oral cancer are being analysed to understand the molecular basis of genomic instability. The mechanism of spindle assembly checkpoint is being investigated to understand its role in aneuploidy.
  • Systematic search for the single nucleotide polymorphisms in DNA repair genes is being carried out to identify the susceptibility alleles for the development of oral cancer.
  • We are studying the association between cytokine and chemokine genes polymorphisms and Helicobacter pylori mediated gastroduodenal diseases. We are also performing the functional analysis of disease-associated polymorphisms to understand the biochemical basis of disease susceptibility.

Names of the group members including regular staff with designation and research fellows

Staff Member`s

Mr.Bhaskar Basu,
Contact: basu_bhaskar63@hotmail.com
Lab.Assistant

Students

  1. Dr. Ruma Dey Ghosh (Principal Investigator, DST WOS-A)
  2. Mr. Sanjib Dey (Research Fellow)
  3. Dr. Somsubhra Nath (Research Fellow)
  4. Dr. Damayanti Das Ghosh (Research Associate)
  5. Mr. Pinaki Mondal (Research Fellow)
  6. Ms. Sumana Bhattacharjya(SRF)
  7. Ms. Tania Das (SRF)
  8. Mr. Debrup Sen (SRF)
  9. Mr. Arindam Datta (SRF)
  10. Sk. Kayum Alam (SRF)
  11. Ms. Sangeeta Ghuwalewala (JRF)
  12. Mr. Chetan Jain (JRF)
  13. Mr. Abhishek Chowdhury (JRF)
  14. Mr. Kumar Singha Roy (JRF)

 

List of important Research Articles

  1. Bhattacharjya S., Nath S., Ghose J., Maiti G. P., Bhattacharyya N. P., Panda C. K. and Roychoudhury S. (2012) miR-125b promotes cell death by targeting Spindle Assembly Checkpoint gene MAD1 and modulating mitotic progression. Cell Death and Differentiation 20: 430-442 (2013) 
  2. Nath SMoghe MChowdhury AGodbole KGodbole GDoiphode MRoychoudhury S. (2012) Is Germline transmission of MAD2 gene deletion associated with human foetal loss? Mol Hum Reprod. 18: 554-562 (2012) 
  3. Nath S., Banerjee T., Sen D., Das T., and Roychoudhury S Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10. J. Biol. Chem. 286: 15666-15677 (2011)  
  4. Banerjee T., Nath S. and Roychoudhury S. DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling. Nucleic Acids Res. 37:2688-2698 (2009)    
  5. Chakravorty M., Datta De D., Choudhury A., and Roychoudhury S. IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int. J. Biochem. Cell Biol 41:1502-1510 (2009)  
  6. Mondal G., Sengupta S., Panda C. K., Gollin S.M., Saunders W. S. and Roychoudhury S. Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer. Carcinogenesis                 28:81-92 (2007)   
  7. Sengupta S., Chakrabarti S., Roy A., Panda C. K. and Roychoudhury S. Inactivation of hMLH1 and hMSH2 in HNSCC tumors and leukoplakia by promoter hypermethylation and its relation with MIN phenotype. Cancer 109:703-712 (2007)   
  8. Chakravorty M., Ghosh A., Choudhury A., Santra A., Hembrum J., Roychoudhury S. Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer. Human Mutation 27: 411-419 (2006)
  9. Mondal G., Boral R. N. and Roychoudhury S. A new Mad2 interacting domain of Cdc20 is critical for the function of Mad2/Cdc20 complex in the spindle assembly checkpoint. Biochem. J.396: 243-53 (2006).   
  10. Mitra S., Sikdar N., Misra C., Gupta S., Paul R. R., Roy B., Panda C. K. and Roychoudhury S. Risk assessment of p53 genotypes and haplotypes in tobacco associated leukoplakia and oral cancer patients from eastern India. Int J Cancer 117: 786-793 (2005)  
 
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Updated on 13th Sep '2013


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