Cancer Biology & Inflammatory Disorder Division

Dr. Mrinal Kanti Ghosh

Phd,FNASC,FAScT

Ph. D.(2000): University of Calcutta, W.B., India.
PDF (1997-2003): Dept. of Molecular Biology, Cleveland Clinic Foundation, OHIO, USA.
Staff (2003-2005): Dept. of Cancer Biology, Cleveland Clinic Foundation, OHIO, USA.


Contact - mrinal.res@gmail.com / mrinalghosh@iicb.res.in


Principal Scientist

Lab Website : Click Here

Current Research Interest

 
    Signal Transduction in Cancer & Stem Cells
  • Cancer has a multifaceted character which is inherent in its very origin. Diverse arrays of aberrations are required before a normal cell in your body will defy ‘social behavior’ to fulfill its only purpose – to proliferate - at the expense of you. By then, deep down at the molecular level crucial signalling pathways would have been extensively rewired. Proteins such as p53 and PTEN which keeps scrupulous cellular growth in check are lost functionally; whereas proteins accelerating growth, such as STAT3, β-catenin and c-Myc, are up-regulated. Protein kinases like Akt and CK2 regulate these players by phosphorylation at critical residues that have important bearing upon their functions. Another class of proteins that include E3 ubiquitin ligases like CHIP and deubiquitinases like HAUSP regulate these same players by governing their half-lives. Our lab is interested and actively working on all these aspects of a tumour cell. To understand cancer and to be able to intervene in its progression we concentrate on these most basic mechanisms. An appreciation of these will probably take us one step further in the way to treating cancer.
  • Cross-regulation of Wnt/β-catenin and EGFR Signalling in Cancer: Our aim is to determine the major pathways responsible for the activation and nuclear localization of Stat3 & β-catenin in human cancer & cancer stem cells and study in particular, the involvement of EGFR & Wnt signaling for this regulation. In this context, the mechanism of nuclear accumulation of β-catenin and its subsequent trans-activation of downstream targets also plays a crucial role in cancer development. The unraveling of the potential intersections of these pathways in glioma, breast and prostate cancer may provide novel targets for drug discovery.
  • Role of DEAD Box RNA Helicases in Cancer: RNA Helicases play crucial roles in developmental processes. Recently, it has been implied that its involvement in transcription is very important in cancer progression. In our present study we would like to study the regulation of p68/p72 through EGFR & Wnt signaling and importance in cancer progression.
  • Role of Ubiquitinases and Deubiquitinases in Cancer: Ubiquitin ligases and deubiquitinases play major roles in cellular physiology by modulating half-lives of numerous proteins. Because ubiquitination and deubiquitination events can influence the time a protein spends inside the cell and the space it occupies during that time, a balance between these events is necessary for maintaining cellular homeostasis and normal functioning. Cancer cells are thought to bypass this balance towards a net increase in proliferation and growth. Therefore, understanding these key mechanisms is important for combating cancer.
  • Role of Casein Kinase II in Modulation of Cancer Cell Signaling: Casein Kinase II/CKII is a ubiquitously expressed Ser/Thr kinase present in all cells, with known upregulated activity in Cancers (e.g. Prostate, Brain Breast etc.). Our aim is to study the various oncogenic signalings initiated and modulated by CKII, and decipher the mechanistic detail how such signaling modulation is responsible for oncogenicity of a cell. Presently among various players, we are interested to investigate the crosstalk of CKII with AKT (another well known oncogenic kinase), PML (an important nuclear sequestering protein) and DAXX (an adapter protein).
  • Drug Discovery: Anti-cancer drug discovery from natural products and using target based synthetic peptides.

Names of the group members including regular staff with designation and research fellows

Fellow/RA
        1. Neerajana Datta (SRF) : neerajana.datta@gmail.com
        2. Veenita Khare (SRF) : k.veenita@gmail.com
        3. Gouranga Saha (JRF) : gourangamalda@gmail.com
        4. Satadeepa Kal (JRF) : satadeepakal@gmail.com
        5. Dipankar Chakraborty (JRF) : dipankar390@gmail.com
        6. Bhaskar Basu (JRF) : bhaskar.recon@gmail.com
        7. Shaheda Tabassum (JRF) : itsme_shaheda@yahoo.in
        8. Sayak Chakravarti (JPF) : sayak.chakravarti@gmail.com
        9. Rajni Shaw (JRF) : rajnig6@gmail.com

        SRA/WOS

        1. Paramita Bhattacharyya (DST-WOS): paramita_b2k@yahoo.co.in

Positions are open for individuals with excellent academic credentials.
M.Sc. (life sciences) students with JRF award interested in Biomedical Research may directly contact for the possibilities of joining our research team.  When contacting us please include your resume with a passport size photo via E-mail. Research experience in good academic Institutions will also be encouraged.

List of important Research Articles (2012----2016)

Articles(Key findings)

  1. M Sarkar, V Khare and MK Ghosh* (2016). The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis. Oncogene (In press). {IF= 7.9}
  2. Sarkar M, Khare V†, Guturi KKN†, Das N and Ghosh MK* (2015). The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis. Oncogene 34: 5843–5856. {IF= 8.5}
  3. Das N, Datta N, Chatterjee U and Ghosh MK* (2016). ERα transcriptionally activates CK2α: a pivotal regulator of PML and AKT in oncogenesis. Cell Signal 26: 1725-1734. {IF= 4.3}
  4. Ahmed SF, Das N, Sarkar M, Chatterjee U, Chatterjee S, and Ghosh MK* (2015). Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis. Molecular Therapy 23: 255–269. {IF= 6.8} 10.
  5. Bhattacharya S and Ghosh MK* (2015). HAUSP regulates cMyc via deubiquitination of TRRAP. Cell Oncol 38: 265-77. {IF= 3.6}
  6. Ghosh A, et al., (2016). Formulation and antitumorigenic activities of nanoencapsulated nifetepimine: A promising approach in treating triple negative breast carcinoma. Nanomedicine: NBM 12 (2016) 1973–1985. {IF= 6.1}
  7. Guturi KK, Sarkar M, Bhowmik A#,  Das N#  and Ghosh MK* (2015). DEAD box protein p68 is regulated by β-catenin/TCF4 to maintain a positive feedback loop in control of breast cancer progression. Breast Cancer Research 16:496.  
  8. Bhattacharya S and Ghosh MK* (2014). HAUSP, a novel deubiquitinase for Rb – MDM2 the critical regulator.FEBS Journal 281: 3061–3078. 
  9. Mandal T, Bhowmik A, Chatterjee A, Chatterjee U, Chatterjee S and Ghosh MK* (2014).Reduced phosphorylation of Stat3 at Ser-727 mediated by Casein Kinase 2 - Protein Phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells. Cellular Signaling 26: 1725-1734.
  10. Chatterjee A, Chatterjee U and Ghosh MK* (2013) Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner: implications in human Prostate Cancer. Cell Death Dis. 4: e543.
  11. Bhowmik A, Das N, Pal U, Mandal M, Bhattacharya B, Sarkar M, Jaisankar P, Maiti NC, Ghosh MK* (2013). 2,29-Diphenyl-3,3'-Diindolylmethane: A Potent Compound Induces Apoptosis in Breast Cancer Cells by Inhibiting EGFR Pathway. PLoS One 8: e59798.
  12. Paul I, Ahmed F, Bhowmik A, Deb S and Ghosh MK* (2013). The Ubiquitin Ligase CHIP Regulates c-Myc Stability and Transcriptional Activity. Oncogene 32: 1284-95.
  13. Ahmed F, Deb S, Paul I, Mandal T, Chatterjee A and Ghosh MK* (2012). Stability and transcriptional activity of PTEN is controlled by E3 ubiquitin ligase CHIP. J Biol Chem. 287: 15996–16006.
  14. Naidu GKK, Mandal T, Chatterjee A, Sarkar M, Bhattacharya S, Chatterjee U and Ghosh MK* (2012). Crosstalk between Wnt/β-catenin and EGFR signaling is negatively controlled by GSK3β in prostate cancer. J Biol Chem. 287: 18287-96. 

Other Key Findings

  1. Sha J†, Ghosh MK†, Zhang K and Harter ML (2010). E1A interacts with two divergent pathways to induce quiescent cells into S phase. J Virol 84: 4050-59. *Contributed equally to the work. {IF= 4.66}
  2. Ghosh MK, Sharma P, Harbor PC, Rahaman SO and Haque SJ (2005). PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene 24: 7290-300. {IF=8.559}
  3. Sha J†, Ghosh MK†, Zhang K and Harter ML (2010). E1A interacts with two divergent pathways to induce quiescent cells into S phase. J Virol 84: 4050-59. *Contributed equally to the work. {IF=4.66}
  4. Ghosh MK and Harter ML (2003). A viral mechanism for remodeling chromatin structure in Go cells. Mol Cell 12: 255-260. {IF=15.052}
  5. Chattopadhyay D, Ghosh MK, Mal A and Harter ML (2001). Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. J Virol 75: 9844-9856. {IF=4.66}
  6. Mal A, Sturniolo M, Schiltz RL, Ghosh MK and Harter ML (2001). A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: Inhibition of the myogenic program. EMBO J 20: 1739-1753. {IF=10.71}
  7. Mal A, Chattopadhyay D, Ghosh MK, Poon RYC and Harter ML (2000). p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells. J Cell Biol. 149: 281-292. {IF=9.688}

Reviews

  1. 1. Bhowmik A, Basu M, Ghosh MK* (2016). Design, synthesis and use of peptoids in the diagnosis and treatment of cancer. Frontiers in Bioscience, Elite (In press).
  2. Sarkar M and Ghosh MK* (2016). DEAD box RNA helicases: crucial regulators of gene expression and oncogenesis. Frontiers in Bioscience, Landmark Edition 21: 1-363. {IF=4.2}
  3.  Paul I and Ghosh MK* (2016). Chaperones and Glioma Immunotherapy. J. Cancer Sci Ther 8: 069-070. {IF=3.2}
  4. Paul I and Ghosh MK* (2015). A CHIPotle in physiology and disease. Int J Biochem Cell Biol 58: 37–52. {IF=4.37
  5. Bhowmik A, Khan R and Ghosh MK* (2015). Blood brain barrier: A challenge for effectual therapy of brain tumors. BioMed Res Int. Article ID 320941. {IF=2.71}
  6. Paul I and Ghosh MK* (2014). The E3 ligase CHIP: insights into its structure and regulation. BioMed Res Int. Article ID 918183. {IF=2.71}
  7. Bhattacharya S and Ghosh MK* (2014). Cell Death and Deubiquitinases: Perspectives in Cancer. BioMed Res Int. Article ID 435197. {IF=2.71}
  8. Paul I†, Bhattacharya S†, Chatterjee A and Ghosh MK* (2013). Current understanding on EGFR and Wnt/β-catenin signaling in glioma and their possible crosstalk. Genes & cancer 4(11-12):427-446.

Book Chapters

  1. Ahmed SF and Ghosh MK *(2013). Post-Translational Regulation of PTEN and its Implication in Cancer. Chapter-2 of Book entitled "PTEN: Structure, Mechanism-of-Action, Role in Cell Signaling and Regulation" published by Nova Science Publishers, Inc.
  2. Paul I, Basu M and Ghosh MK* (2016). CHIP (Carboxy Terminus of HSC70 Interacting Protein). Encyclopedia of Signaling Molecules (In press).
 
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Updated on 18th,November, 2016


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