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Cancer Biology & Inflammatory Disorder Division

Dr. Malini Sen

Senior Scientist
PhD, Albert Einstein College of Medicine, NY, USA
Postdoctoral Associate, RWJ Pharmaceutical Research Institute, La Jolla, CA, USA
Project Scientist, Medicine Department, University of California – San Diego, USA
email:msen@iicb.res.in

Current Research Interest

  • Evaluating the role of Wnt Signaling in Rheumatoid Arthritis (RA) and other autoimmune and inflammatory disorders.
  • Evaluating the role of WISP3 (Wnt induced secreted protein 3) in the regulation of oxidative stress and fibrosis.
  • Investigating means for inhibition of inflammation, oxidative stress and fibrosis upon detailed analysis of appropriate signal transduction pathways.

I have positions open for individuals with NET (CSIR/UGC) fellowships to conduct research on mechanisms of disease pathogenesis.
malini

Names of the group members including regular staff with designation and research fellows:

JRF/SRF/RA

  1. R. Srinivas Rao (JRF), E Mail : vasu369.srinivas@gmail.com
  2. George Maiti (JRF), E Mail : geobiokgp@gmail.com
  3. Debdut Naskar (JRF), E Mail : debdut1984@gmail.com
  4. Milan Patra (JRF), E Mail : mln.patra@gmail.com

List of important Publications:

  1. Miller DS and Sen M. 2007.  Potential role of WISP3 (CCN6) in regulating the accumulation of reactive oxygen species. BBRC 355: 156 – 61.

  2. Davis L, Chen Y and Sen M. 2006. WISP3 functions as a ligand and promotes superoxide dismutase activity. BBRC 342: 259 – 65.

  3. Sen M. 2005. Wnt Signaling in Rheumatoid Arthritis. Rheumatology 44: 708 – 713.

  4. Sen M, Cheng Yu-Ho, Goldring MB, Lotz M and Carson DA. 2004. WISP-3 dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheumatism 50: 488 – 97.

  5. Lu D, Zhao Y, Tawatao R, Cottam H, Sen M, Leoni L, Kipps TJ, Corr M and Carson DA. 2004. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. PNAS 101: 3118 – 23.

  6. Sen M, Reifert J, Lauterbach K, El-Gabalawy H, Rubin JS, Wolf V, Corr M and Carson DA. 2002. WNT signaling in rheumatoid arthritis synoviocytes regulates fibronectin and metalloproteinase expression. Arthritis Rheumatism46: 2867 – 77.

  7. Rhee CS, Sen M, Wu C, Leoni L, Rubin J, Corr M and Carson DA. 2002. Wnt and Frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas.  Oncogene 21: 6598 – 605.

  8. Sen M, Chamorro M, Reifert J, Corr M, and Carson DA. 2001. Blockade of Wnt-5A / Frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheumatism44: 772-781.

  9. Schmid M, Sen M, Rosenbach MD, Carrera CJ, Friedman H and Carson DA.  2000. A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.  Oncogene 19: 5747-5754.

  10. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M and Carson DA. 2000. Expression and function of wingless and frizzled homologs in rheumatoid arthritis.  PNAS 97: 2791-2796.

Detail list of Publications upto December'2010 ==>> Click here

 
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Updated on 20th January'2011
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