Dr. C. Mandal
Outstanding Scientist & Head

PhD, F.N.A.,F.A.Sc,F.N.A.Sc.
Contact - chitra@csiriicb.in / Chitra_mandal@yahoo.com

Current Research Interest

Main theme of our group is to understand the mystery of glycosylation of biomolecules modified specifically in patients with leukemia and visceral leishmaniasis and their potential applications in medical research. The following aspects are being investigated: Exploration of modified sialoglyconjugates induced on immune cells and plasma/ sera of both host and parasites Proteomics of these purified clinically important molecules to identify host protective molecules Development of antigen based diagnostic tool and their biological role in Visceral leishmaniasis (VL). Investigation of O-acetylated sialoglycotopes in childhood acute lymphoblastic leukemia (ALL) and the role of the disease-specific antigen and antibodies in understanding the disease-biology. Role of glycosylation mainly differential sialylation in adhesion process and cell signaling of hematopiotic stem cell for their potential application in childhood ALL. Programmed cell death of cancer cell and signaling Understanding of glycosylated molecular variants of human C-reactive proteins, an innate immune component, in relation to different pathological conditions Names of the group members including regular staff with designation and research fellows: Staff Member Mr. Asish Mullick Extn.No.717 Sr. Technical Officer (2) Project Assistant Ms. Sayantani Sarkar Sr.Project Fellow Ms. Devawati Dutta Sr.Project Fellow Mr. Nilmadhab Mondal P.A. Lavel-II Ms. Rita Maity P.A. Lavel-II Research Fellows Dr. Chandan Mandal Research Associate Mr. Biswajit Khatua CSIR - Senior Research Fellow Mr. Kaushik Bhattacharya CSIR - Senior Research Fellow Mr. Suman Kr. Samanta CSIR - Senior Research Fellow Mr. Saptarshi Roy CSIR - Senior Research Fellow Ms. Arup Kr. Bag  ICMR - Senior Research Fellow Mr. Ranjita Das CSIR - Senior Research Fellow Mr. Anjan Talukder CSIR - Senior Research Fellow

List of important Publications:

1. S Mondal, K. Bhattacharya, A. Mallick, R. Sangwan and Chitra Mandal (2012) Bak compensated for Bax in p53-null Cells to Release Cytochrome c for the Initiation of Mitochondrial Signaling during Withanolide D-induced Apoptosis.PLoS ONE 7(3): e34277. Epub 2012 Mar 29
2. B. Khatua, K. Bhattacharya and Chitra Mandal (2012) α2,3 linked Sialic acids acquired by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9.  Journal of Leucocyte Biology, 91, 641-55. Epub Jan 11
3. Chandan Mandal,  Chhabinath Mandal, S. Chandra,  R. Schauer and Chitra Mandal (2012) Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia Glycobiology 22:70-83
4. S. Kushwaha, S. Roy, R. Maity, A. Mallick, VK. Sonia, PK. Singha, ND. Chaurasiya, R. S. Sangwan, S. Misra-Bhattacharya and Chitra Mandal (2012) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice. Vaccine, 30, 1077-1087
5. Chandan Mandal and Chitra Mandal (2012) Identification and analysis of O-acetylated glycoproteins, A chapter in “Methods in Molecular Biology” Chapter 6, Series Editor Dr. John Walker, Human Press, Springer publishing group, USA (in press)
6. Chowdhury S, Mandal C, Sarkar S, Bag AK, Vlasak R, Chandra S, Mandal Chitra (2012) Mobilization of lymphoblasts from bone marrow to peripheral blood in childhood acute lymphoblastic leukaemia: Role of 9-O-acetylated sialoglycoproteins. Leukemia Res 36, 146-55
7. S. Samanta, D Dutta, A Ghoshal, S Mukhopadhyay, B Saha, S Sundar, S Jarmalavicius, M Forgber, CN Mandal, P Walden and Chitra Mandal (2011) Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis PLOS one, Accepted
8. Chandan Mandal,  Chhabinath Mandal, S. Chandra,  R. Schauer and Chitra Mandal (2011) Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia Glycobiology, in press
9. Mandal Chitra, Roychoudhury S, Roy S. (2011) Cancer research: India meets the West. Cell Death Differ. Jun 17. doi: 10.1038/cdd.2011.85
10. S. Mondal, S. Bandyopadhyay, M. K Ghosh, S. Mukhopadhyay, S. Roy and Chitra Mandal (2011). Natural products: Promising resources for cancer drug discovery. Anti Cancer Agents in Medicinal Chemistry, (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) Jun 27. [Epub ahead of print], PMID: 21707502 [PubMed - as supplied by publisher
11. Chitra Mandal, R. Schwartz-Albiez and R. Vlasak (2011) Functions and biosynthesis of O-acetylated sialic acids. A Review "Topics in Current Chemistry" Volume: SialoGlyco Chemistry and Biology, Volume Editors: Rita Gerardy-Schahn, Philippe Delannoy, Mark von Itzstein (accepted) 
12. S. Mondal, S. Roy, R. Maity, A. Mallick, R. Sangwan, S. Misra-Bhattacharya and Chitra Mandal (2011) Withanolide-D, carrying the baton of Indian Rasayana herb as a lead candidate of anti-leukemic agent in modern medicine. Adv Expl Med and Biol, Kluwer Academic Publishers.
13. A. Ghoshal and Chitra Mandal (2011) A perspective on the emergence of sialic acids as potent determinants affecting Leishmania biology. Molecular Biology International (accepted)
14. K. Mukherjee, S. Chowdhury, S. Mondal, Chandan Mandal, S. Chandra and Chitra Mandal (2011) 9-O-Acetyl GD3 in lymphoid and erythroid cells. Adv Expl Med and Biol 705:317-334, Kluwer Academic/Plenum Publishers, New York, USA 
15. Angana Ghoshal, Gerrit J. Gerwig, Johannis P. Kamerling, and Chitra Mandal (2010) Sialic acids in different Leishmania spp., its correlation with nitric oxide resistance and host responses.  Glycobiology  (accepted)
16. Kaushik Bhattacharya, Suman K. Samanta, Rakshamani Tripathi, Asish Mallick, Sarmila Chandra, Bikas C. Pal, Chandrima Shaha and Chitra Mandal (2010) Apoptotic effects of mahanine on human leukemic cells are mediated through cross talking between Apo-1/Fas signaling with Bid protein and via mitochondrial pathways. Biochemical Pharmacology 79: 361-72.
17. Chandan mandal, Cristina Tringali, Susmita Mondal, Leugi Anastasia, Sarmila Chandra, Venerando Burno and Chitra Mandal (2010) Down-regulation of membrane-bound Neu3 is negatively correlated with disease progression and associated with apoptosis suppression of lymphoblasts in childhood acute lymphoblastic leukemia. International J Cancer 126:337-349
18. Jain R, Ghoshal A, Mandal Chitra, Shaha C. (2009) Leishmania cell surface prohibitin: role in host-parasite interaction. Cell Microbiol. Nov 2. [Epub ahead of print]  PMID: 19888987
19. Khatua B, Ghoshal A, Bhattacharya K, Mandal C, Saha B, Crocker PR, Mandal Chitra. (2009). Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition.  FEBS Lett. Nov 27. [Epub ahead of print] PMID: 19945458
20. Susmita Mondal, Chandan Mandal, Sarmila Chandra and Chitra Mandal (2009) Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia. Leukemia Research     Aug 24. [Epub ahead of print] PMID: 19709745
21. Rajdeep Chowdhury, Suchandra Chowdhury, Paromita Roychoudhury, Chitra Mandal and Keya Chaudhuri (2009) Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation. Apoptosis 14, 108-123
22. Aparajita Pal, Iman Bhattacharya, Kaushik Bhattacharyya, Chitra Mandal, Manju Ray (2009) Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in Sarcoma-180 bearing mice: Involvement of MAP kinase, NF kb signal transduction pathway. Molecular Immunology 46, 2039-44
23. Angana Ghoshal, Sumi Mukhopadhyay, Rodion Demine, Michael Forgber, Saulius Jarmalavicius, Bibhuti Saha, Shyam Sundar, Peter Walden, Chhabinath Mandal, and Chitra Mandal (2009) Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis. Glyconjugate Journal 26, 675-89.
24. Waliza Ansar, Sumi Mukhopadhyay, Shyamasree Basu, SK. Hasan Habib, Bibhuti Saha, Asish Kumar Sen, Chhabinath Mandal, and Chitra Mandal (2009) Disease-associated glycosylated moleclar variants of human C-reactive protein activate complement-mediated hemolysis of erythrocytes in tuberculosis and Indian Visceral leishmaniasis. Glycoconjugate J 26, 1151
25. Chandan Mandal, G. Vinayaga Srinivasan, Suchandra Chowdhury, Sarmila Chandra, Chhabinath Mandal, Roland Schauer, and Chitra Mandal (2009) High Level of Sialate-O-acetyltransferase Activity in Lymphoblasts of Childhood Acute Lymphoblastic Leukaemia (ALL): Enzyme Characterization and Correlation with Disease Status. Glycoconjugate Journal 26, 57-73
26. Waliza Ansar, SK. Hasan Habib, Samir Roy, Chhabinath Mandal and Chitra Mandal (2009). Unraveling the C-reactive protein complement-cascade in destruction of red blood cells: Potential Pathological Implications In Plasmodium falciparum Malaria. Cellular physiol biochem 23, 175-190
27. Kankana Mukherjee, Anil  K  Chava, Suman  Bandyopadhyay, Asish  Mallick, MSc; Sarmila Chandra, Chitra mandal (2009). Co-expression of 9-O-acetylated sialoglycoproteins and their binding proteins on lymphoblasts of childhood acute lymphoblastic leukaemia: an anti-apoptotic role. Biol Chemistry 2009 390, 325-335
28. Angana Ghoshal, Sumi Mukhopadhyay, Bibhuti saha, and Chitra Mandal (2009) 9-O-acetylated sialoglycoproteins: Important immunomodulators in Indian visceral leishmaniasis, Clinical and Vaccine Immunology 18, 889-898
29. Sambuddha Banerjee, Susmita Mondal, Soma Sen, Saurabh Das, David L. Hughes, Corrado Rizzoli, Cédric Desplanches, Chitra Mandal and Samiran Mitra (2009) Four New Dinuclear Cu(II) Hydrazone Complexes Using Various Organic Spacers: Syntheses, Crystal Structures, DNA Binding and Cleavage Studies and Selective Cell Inhibitory Effect Towards Leukemic and Normal Lymphocytes.  Dalton Trans, 4:6849-60.
30. Chandan Mandal, Avijit Dutta, Asish Mallick, Sarmila Chandra, Laxminarain Misra, Rajender  Sangwan, and Chitra Mandal (2008) Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin in a transcription-dependent manner through mitochondrial death cascade.  Apoptosis. 13, 1450-1464
31. Kankana Mukherjee, Anil Kumar Chava, Chandan Mandal, Sailendra Nath Dey, Bernhard Kniep, Sarmila Chandra, Chitra Mandal (2008) O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia. J. Cell biochem, 2008 105, 724-34
32. Suchandra Chowdhury, Suman Bandyopadhyay, Chandan Mandal, and Sharmila Chandra, and Chitra Mandal  (2008) Flow-cytometric monitoring of disease-associated expression of 9-0 acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal fllow-up study BMC Cancer, 8, 40
33. Angana Ghoshal, Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal (2008) sialoglycotherapeutics in protozoal diseases Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers, 8, 358-369
34. Avijit Dutta, Debjani Sarkar, Ameenah Gurib-Fakim, Chitra Mandal* and Mitali Chatterjee (2008) In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis. Parasitol Res 102, 1235-42
35. Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal (2008) Targeting glycoproteins or glycolipids and their metabolic pathways for anti-parasite therapy, Review, Advances in Experimental Medicine and Biology   625: 87-102.

Detail list of Publications upto April'2012 ==>> Click here

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