Cancer Biology & Inflammatory Disorder Division

Professor Chitra Mandal

Ph.D, FTWAS, FNA, FASc, FNASc, FAMS

Contact: chitra_mandal@yahoo.com / cmandal@iicb.res.in

Curicullum Vitae

 

J.C. Bose National Fellow

Distinguished Biotechnology Research professor

 

2014-15: Acting Director, CSIR-IICB , Project Director, NIPER-Kolkata

2010-15: Head, CSIR-Innovation Complex, Kolkata

1981-2015: Scientist B to Scientist-H, CSIR-IICB

1978 -81: Post Doc, University of Pennsylavania, Philadelphia, USA

1974-78: Ph.D (Bio-Organic Chemistry), Indian Institute of Science, Bangalore

 

Current Research Interest:

The main aim of our laboratory is to understand the mystery of glycosylation of biomolecules with special emphasis on the role of sialoglycoconjugates in different disease models and its potential applications in disease management, its specificity and recognition in immune responses mainly in the field of cancer biology/tumor immunology and host-pathogen interactions dealing with visceral leishmaniasis (VL) and Pseudomonas aeruginosa (PA). We have analyzed childhood acute lymphoblastic leukemia (ALL), VL and PA-associated biomolecules by exploring the diversity of sialylation with a common set of questions through proteomic and glycobiological aspects.

Additionally, another important goal of our laboratory is to deliver low cost affordable healthcare to all using India’s vast resources of medicinal plants. Currently we had put lots of effort towards chemotherapeutic advancement in cancer since 2008. My group has identified a non-toxic herbal molecule alone/or extract/or in-combination with existing-known drugs showing great potential against an array of cancer cell lines/ cancer stem cells both in vitro and in vivo and even in hypoxic condition.

Our activities are broadly divided as follows described below:

 Proteomic, glycomic and glycoimmunological work on sialylated glycoconjugates induced on lymphoblasts and their modulation mainly in childhood acute lymphoblastic leukemia (ALL) and other cancers

 Define cancer cells by glycoenzymology (glycosylation regulating enzymes) and establish the early response disease specific enzymes as diagnostic markers

 Identification of anti-cancer lead herbal molecules based on edible nontoxic medicinal plants and potential targets through signalling cross talks and through Systems Biology approaches

Role of glycosylations/unique sialylation on host immune cells and parasite specific biomolecules in visceral leishmaniasis (VL) and their immunological role in host-pathogen interaction

 

 

Proteomic/glycomic approach on host and pathogen specific biomolecules to address innate immune response for survival of Pseudomonas aeruginosa in hostile environment of host

LAB MEMBERS

Ms. Devawati Dutta, CSIR - Senior Research Fellow

Mr. Eswara Murali Satyavarapu, UGC- Senior Research Fellow

Mr. Samarpan Maiti, UGC-Senior Research Fellow

Ms. Joyshree Karmakar, UGC-Junior Research Fellow

Ms. Shalini Nath, UGC-Junior Research Fellow

Ms. Susmita Mondal, UGC-Junior Research Fellow

Mr. Kaustuv Mukherjee, UGC-Junior Research Fellow

Ms. Rita Maity

 

 

A few Selected Publications

CANCER

  1. K Bhattacharya, S Maiti1 and Chitra Mandal (2016) PTEN negatively regulates mTORC2 formation and signalling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor. Oncogenesis, 5, e227; doi:10.1038/oncsis.2016.34
  2. Mahua R Das, Arup K Bag, Shekhar Saha, Alok Ghosh, Sumit K Dey, Provas Das, Chitra Mandal, Subhankar Ray, Saikat Chakrabarti, Manju Ray and Siddhartha S Jana (2016) Molecular association of Glucose-6-phosphate isomerase and Pyruvate kinase M2 with Glyceraldehyde-3-phosphate dehydrogenase in cancer cells. BMC Cancer, 16:152
  3. Pintu Kumar Khan, Arnab Mahato, Biswanath Kundu, Samit K. Nandi, Prasenjit Mukherjee, Someswar Datta, Soumya Sarkar, Jayanta Mukherjee, Shalini Nath, Vamsi K. Balla & Chitra Mandal (2016) Influence of single and binary doping of strontium and lithium on in vivo biological properties of bioactive glass scaffolds. Scientific Reports, 6:32964 | DOI: 10.1038/srep32964
  4. Aparajita Pal, Dipa Talukdar, Anirban Roy, Subhankar Ray, Asish Mallick, Chitra Mandal, Manju Ray (2015) Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect” International Journal of Nanomedicine 10, 3499–3518
  5. Sayantani Sarkar, Chandan Mandal, Rajender Sangwan and Chitra Mandal, (2014) Chk1/Chk2 couples with G2/M cell cycle arrest and perturbed canonical Wnt/β-catenin pathway to elicit apoptosis in pancreatic adenocarcinoma’ Endrocine Related Cancer, 21, 1-14
  6. Ranjita Das, Kaushik Bhattacharya, Suman K Samanta, Bikas C Pal and Chitra Mandal, (2014) Improved chemosensitivity in cervical cancer to cisplatin: synergistic activity of mahanine through STAT3 inhibition Cancer Letters 351, 81-90
  7. Ranjita Das, Kaushik Bhattacharya, Sayantani Sarkar, Suman K Samanta, Bikas C Pal and Chitra Mandal, (2014). Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma Apoptosis 19:149-164
  8. Bhattacharya K, Bag AK, Tripathi R, Samanta SK, Pal BC, Shaha C, Mandal Chitra, (2014). Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme. Am J Cancer Res. 4(6):629-47
  9. Suman K. Samanta, Devawati Dutta, Sarita Roy, Kaushik Bhattacharya, Sayantani Sarkar, Bikas C. Pal, Chhabinath Mandal, Anjan K. Dasgupta and Chitra Mandal, (2013). Mahanine, a DNA minor grove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and -NH functional groups. Journal of Medicinal Chemistry, 56:5709-21
  10. S. Sarkar, D. Dutta, S.K Samanta, K. Bhattacharya, B.C Pal, J. Li, K. Datta, CN Mandal, and Chitra Mandal, (2013). Redox sensitive inhibition of Hsp90 coupled with disruption of super-chaperone complex attenuate pancreatic adenocarcinoma in vitro and in vivo Int. J. Cancer 132:695-706. doi: 10.1002/ijc.27687
  11. Sarita Roy, Kaushik Bhattacharya, Chitra Mandal and Anjan K. Dasgupta (2013) Cellular response to chirality and amplified chirality. Journal of Materials Chemistry B. 1:6634-43 DOI: 10.1039/C3TB21322F
  12. Susmita Mondal, K. Bhattacharya, A. Mallick, R. Sangwan and Chitra Mandal, (2012). Bak compensated for Bax in p53-null Cells to Release Cytochrome c for the Initiation of Mitochondrial Signaling during Withanolide D-induced Apoptosis. PLoS ONE 7(3): e34277. Epub 2012 Mar 29
  13. K. Bhattacharya, S.K. Samanta, R. Tripathi, A. Mallick, S. Chandra, BC. Pal, C. Shaha and Chitra Mandal, (2010). Apoptotic effects of mahanine on human leukemic cells are mediated through cross talking between Apo-1/Fas signaling with Bid protein and via mitochondrial pathways. Biochemical Pharmacology 79: 361-72
  14. S Mondal, Chandan Mandal, RS, S Chandra, Chitra Mandal, (2010). Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Molecular Cancer 9, 239
  15. Chandan Mandal, A. Dutta, A. Mallick, S. Chandra, L. Misra, R. Sangwan and Chitra Mandal, (2008). Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin in a transcription-dependent manner through mitochondrial death cascade. Apoptosis. 13, 1450-1464

A few selected publications on

Proteomic and glycomic study of sialylated glycoconjugates induced on lymphoblasts and their modulation in leukemias/cancers

  1. Chandan Mandal, Sayantani Sarkar, Uttara Chatterjee, Reinhard Schwartz-Albiez, Chitra Mandal, (2014) Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage The Int J Biochem Cell Biol,May 16th pii: S1357-2725(14)00173-3
  2. R.K Mehta, S Verma, S Mohanty, P. Jena, B. Khatua, R. Jena, S. Sethy, Chitra Mandal, (2014) K.H. Roehm, and A. Sonawane Mutations in subunit interface and B-cell epitopes improve antileukemic activities of Escherichia coli asparaginase-II: Evaluation of immunogenicity in mice. J. Biol. Chem 289, 35555-70
  3. Bhattacharya, Kaushik; Chandra, Sarmila; Mandal, Chitra, (2014). Critical Stoichiometric ratio of CD4+CD25+FoxP3+ Treg and CD4+CD25- Tresp persuades immunosuppression in patient with B-cell Acute Lymphoblastic Leukemia. Immunology May;142(1):124-39
  4. Chandan Mandal and Chitra Mandal (2013). Identification and analysis of O-acetylated glycoproteins, A chapter in “Methods in Molecular Biology” Chapter 6, Series Editor Dr. John Walker, Human Press, Springer publishing group, USA 981:57-93
  5. Chandan Mandal, Chhabinath Mandal, S. Chandra, R. Schauer and Chitra Mandal (2012). Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia Glycobiology 22:70-83
  6. Chitra Mandal, R. Schwartz-Albiez and R. Vlasak (2012). Functions and biosynthesis of O-acetylated sialic acids. A Review "Topics in Current Chemistry" Volume: SialoGlyco Chemistry and Biology, Volume Editors: Rita Gerardy-Schahn, Philippe Delannoy, Mark von Itzstein, Feb 28, DOI: 10.1007/128_2011_310 2, Springer-Verlag Berlin Heidelberg
  7. Mandal Chitra, Roychoudhury S, Roy S. (2011). Cancer research: India meets the West. Cell Death Differ. 18, 1675–1677, Jun 17. doi: 10.1038/cdd.2011.85 [Epub ahead of print]
  8. Chandan Mandal, C. Tringali, S. Mondal, L.A, S. Chandra, V. Burno and Chitra Mandal, (2010). Down-regulation of membrane-bound Neu3 is negatively correlated with disease progression and associated with apoptosis suppression of lymphoblasts in childhood acute lymphoblastic leukemia. International J Cancer 126:337-349 (Impact factor 5.441)
  9. K. Mukherjee, AK Chava, S. Bandyopadhyay, A. Mallick, S. Chandra, Chitra Mandal, (2009). Co-expression of 9-O-acetylated sialoglycoproteins and their binding proteins on lymphoblasts of childhood acute lymphoblastic leukaemia: an anti-apoptotic role. Biol Chemistry 390, 325-335
  10. S. Chowdhury, S. Bandyopadhyay, Chandan Mandal, and S. Chandra, and Chitra Mandal, Flow-cytometric monitoring of disease-associated expression of 9-O-acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal follow-up study BMC Cancer, 8, 40, (2008).
  11. S. Bandyopadhyay, A. Bhattacharyya, A.K. Sen, T. Das, G. Sa, D. K. Bhattacharya and Chitra Mandal, (2005). Over expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia (ALL) International Immunology 17,177-91
  12. S. Ghosh, S. Bandyopadhyay, S. Pal, B. Das, D.K. Bhattacharya and Chitra Mandal, (2005). Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of over expressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukemia. British J Hematol 128: 35-41
  13. S. Ghosh, S. Bandyopadhyay, A. Mullick, S. Pal, R. Vlasak, D.K. Bhattacharya and Chitra Mandal, (2005). Interferon gamma promotes survival of lymphoblasts over-expressing 9-O-acetylated sialoglycoconjugates in childhood acute lymphoblastic leukemia. J. Cellular Biochemistry 95, 206-16
  14. S. Bandyopadhyay, K. Mukherjee, M. Chatterjee, D.K. Bhattacharya and Chitra Mandal, (2005), Detection of immune-complexed 9-O-acetylated sialoglycoconjugates in the sera of patients with pediatric acute lymphoblastic leukemia. J. Immunol Method 297,13-26 (Impact factor 2.74)
  15. S. Ghosh, D.K. Bhattacharya and Chitra Mandal, (2005). Altered erythrocyte membrane characteristics during anemia in childhood acute lymphoblastic leukemia. Ann Hematol 84, 76-84
  16. S. Pal, S. Ghosh, S. Bandyopadhyay, C.N. Mandal, S. Bandhyopadhyay, D. K. Bhattacharya and Chitra Mandal, (2004). Differential expression of 9-O-acetylated sialoglycoconjugates on leukemic blasts: a potential tool for long-term monitoring of children with acute lymphoblastic leukaemia. Internat. J. Cancer 111, 270-277
  17. S. Pal, S. Bandhyopadhyay, M. Chatterjee, A.G. Hall, D.K. Bhattacharya and Chitra Mandal, (2004), Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia. Clinical Biochem 37, 395-403
  18. S. Pal, S. Ghosh, C.N Mandal, G. Kohla, R. Brossmer, R Isecke, A. Merling, R. Schauer, Pal S, Chatterjee M, Bhattacharyya DK, Bandhyopadhyay S and Mandal Chitra (2000). Identification and purification of cytolytic antibodies directed against O-acetylated sialic acid in childhood acute lymphoblastic leukemia. Glycobiology. 10, 539-549
  19. Mandal Chitra, Chatterjee M, Sinha, D. (2000). Investigation of 9-O-Acetylated sialoglycocongugates in childhood acute lymphoblastic leukaemia. British J. Hematol. 110, 801-812
  20. Pal S, Chatterjee M, Bhattacharyya DK, Bandhyopadhyay S and Mandal Chitra (2000). Identification and purification of cytolytic antibodies directed against O-acetylated sialic acid in childhood acute lymphoblastic leukemia. Glycobiology. 10, 539-549
  21. Sinha D, *Mandal Chitra and Bhattacharya DK, A colorimetric assay to evaluate the chemotherapeutic response of children with Acute Lymphoblastic Leukemia (ALL) employing achatinin: a 9-O acetylated sialic acid binding lectin. Leukemia Res. 23, 803-809(1999).
  22. Sinha D, *Mandal Chitra and Bhattacharya DK, Development of a simple, blood based lymphoproliferation assay to assess the clinical status of patients with acute lymphoblastic leukemia. Leukemia Research 23, 433-439(1999).
  23. 21. Sinha D, *Mandal Chitra and Bhattacharya DK, (1999). Identification of 9-O acetyl sialoglycoconjugates (9-OAcSGs) as biomarkers in childhood acute lymphoblastic leukemia using a lectin, AchatininH, as a probe. Leukemia, 13; 119-125 (Impact factor10.561) *Corresponding author
  24. Sinha D, *Mandal Chitra and Bhattacharya DK, (1999). A novel method for prognostic evaluation of childhood acute lymphoblastic leukemia. Leukemia, 13, 309-312 (Impact factor 10.561) *Corresponding author

Understanding sialoglycobiology of Pseudomonas aeruginosa (PA) for their survival in host

  1. Biswajit Khatua, Jeremy Van Vleetb, Biswa Pronab Choudhuryb, Chitra Mandal, Sialylation of OprD protein: A mechanistic basis of antibiotic uptake in Pseudomonas aeruginosa. Molecular & Cellular Proteomics 13(6):1412-28. Impact factor 7.4(2014). 5yrs average IF 8.4
  2. Biswajit Khatua, Saptarshi Roy and Chitra Mandal, Sialic acids siglec interaction: A unique strategy to circumvent innate immune response by pathogens. An invited review Indian Journal of Medical Research 138(5):648-62(2013).
  3. B. Khatua, K. Bhattacharya, Chitra Mandal, α 2,3 linked Sialic acids acquired by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9. Journal of Leucocyte Biology, 91, 641-55. Epub Jan 11 (2012) (Impact factor 4.992)
  4. Khatua B, Ghoshal A, Bhattacharya K, Mandal Chandan, Saha B, Crocker PR, Mandal Chitra. (2010). Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition. FEBS Lett. 584, 555-561 Impact factor 3.60

Role of glycosylations/unique sialylation on host immune cells and parasite specific biomolecules in visceral leishmaniasis (VL) and their immunological role in host-pathogen interaction

  1. Pintu Kumar Khan, Arnab Mahato, Biswanath Kundu, Samit K. Nandi, Prasenjit Mukherjee, Someswar Datta, Soumya Sarkar, Jayanta Mukherjee, Shalini Nath, Vamsi K. Balla & Chitra Mandal (2016) Influence of single and binary doping of strontium and lithium on in vivo biological properties of bioactive glass scaffolds. Scientific Reports, 6:32964 | DOI: 10.1038/srep32964
  2. Kumar GA, Roy S, Jafurulla M, Mandal Chitra, Chattopadhyay A (2016) Statin-induced chronic cholesterol depletion inhibits Leishmania donovani infection: Relevance of optimum host membrane cholesterol. Biochim Biophys Acta, 1858(9):2088-96
  3. Mandal A, Das S, Roy S, Ghosh AK, Sardar AH, Verma S, Saini S, Singh R, Kumar A, Mandal Chitra, Das P (2016) Deprivation of L-Arginine induces Oxidative stress mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine pathway. PLoS Negl Trop Dis, DOI:10.1371/journal.pntd.0004373
  4. Bag AK, Saha S, Sundar S, Saha B, Chakrabarti A, Mandal Chitra, (2014) Comparative proteomics and glycoproteomics of plasma proteins in Indian visceral leishmaniasis. Proteome Sci. 12 (1):48 This work has been highlighted in Aalatimes English News    paperwww.aalatimes.com/2012/11/20/Indin-scientists-unravel-secret-behind-hospital-infection
  5. Sajal Samanta, Angana Ghoshal, Kaushik Bhattacharya, Bibhuti Saha, Peter Walden and Chitra Mandal Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis PLoS ONE 7(7):e42361.doi: 10.1371/journal.pone.0042361. Epub 2012 Jul 31(2012).
  6. A Ghoshal, G.J. Gerwig, J.P. Kamerling, and Chitra Mandal (2010) Sialic acids in different Leishmania spp., its correlation with nitric oxide resistance and host responses. Glycobiology 20: 553-66.
  7. Jain R, Ghoshal A, Mandal Chitra, Shaha C. (2010) Leishmania cell surface prohibitin: role in host-parasite interaction. Cell Microbiol. 12, 432-52.
  8. Ghoshal, S. Mukhopadhyay, R. Demine, M. Forgber, S. Jarmalavicius, B. Saha, S. Sundar, P. Walden, Chhabinath Mandal and Chitra Mandal (2009) Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis. Glycocon J 26, 675-89. (Impact factor 7.446)
  9. W. Ansar, S. Mukhopadhyay, S. Basu, SK.H. Habib, B. Saha, A.K Sen, C. Mandal, and Chitra Mandal (2009) Disease-associated glycosylated moleclar variants of human C-reactive protein activate complement-mediated hemolysis of erythrocytes in tuberculosis and Indian Visceral leishmaniasis. Glycocon J 26, 1151
  10. Ghoshal, S. Mukhopadhyay, B. Saha and Chitra Mandal (2009) 9-O-acetylated sialoglycoproteins: Important immunomodulators in Indian visceral leishmaniasis, Clinical and Vaccine Immunology 18, 889-898
  11. Ghoshal, S. Mukhopadhyay, GJ. Gerwig, J.P. Kamerling, M. Chatterjee, Chitra Mandal (2009) 9-O-acetylated sialic acids enhance entry of virulent Leishmania donovani promastigotes into macrophages, Parasitology. 15:1-15.
  12. Ghoshal, S. Mukhopadhyay nee Bandyopadhyay and Chitra Mandal (2008) sialoglycotherapeutics in protozoal diseases. Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers, 8, 358-369
  13. Mukhopadhyay nee Bandyopadhyay S and Chitra Mandal (2006) Glycobiology of leishmania donovani. Indian J. Medical Res 123, 203-220
  14. A.K. Chava, M. Chatterjee, and Chitra Mandal (2005) O-acetyl sialic acids in parasitic diseases, in a "Hand book of carbohydrate engineering" Edited by Kevin J. Yarema; published by Taylor and Francis Group, book division, USA in Chapter 3, 71-98
  15. Dutta A, Chitra Mandal and M. Chatterjee (2005) Development of a modified MTT assay for screening antimonial resistant field isolates of Indian visceral leishmaniasis. Parasitology International 54, 119-22
  16. S. Bandyopadhyay, M. Chatterjee, T. Das, S. Bandyopadhyay, S. Sundar and Chitra Mandal (2004) Antibodies directed against O-acetylated sialoglycoconjugates accelerate complement activation in Leishmania donovani promastigotes. J. Infect disease 190, 2010-2019
  17. S. Bandyopadhyay, M. Chatterjee, S. Pal, RF Waller, S. Sundar, M. McConville and Chitra Mandal (2004) Antibodies against O-acetylated sialoglycoconjugates; their purification, characterization and application as a novel probe for diagnosis and follow up of Indian Visceral Leishmaniasis patients Diagnostic Microbiology and Infectious Disease 49, 15-24
  18. A.K Chava, M. Chatterjee, V. Sharma, S. Sundar and Chitra Mandal (2004) Variable Degree of alternative complement pathway–mediated hemolysis in Indian visceral leishmaniasis Induced by Differential Expression of 9-O-acetylated sialoglycans, Journal of Infectious Disease 189, 1257-1264
  19. A.K. Chava, M. Chatterjee, GJ. Gerwig, JP. Kamerling and Chitra Mandal (2004) Identification of sialic acids on leishmania donovani amastigotes, Biol. Chem 385, 59-66
  20. A.K. Chava, S. Bandyopadhyay, M. Chatterjee, and Chitra Mandal (2004) Sialoglycans in protozoal diseases; their detection, modes of acquisition and emerging biological roles, a review in Glycoconjugate J 20, 199-206
  21. S. Bandyopadhyay, M. Chatterjee, S. Sundar and Chitra Mandal (2004) Identification of 9-O-acetylated sialoglycans on peripheral blood mononuclear cells in Indian visceral leishmaniasis. Glycoconjugate J 20, 531-536
  22. M. Chatterjee, AK Chava, G. Kohla, S. Pal, S. Hinderlich, GJ. Gerwig, JP. Kamerling, R. Vlasak, PR. Crocker, R. Schauer, R. Schwartz- Albiez and Chitra Mandal (2003) Identification and characterization of adsorbed serum sialoglycans on leishmania donovani promastigotes. Glycobiology 13, 351-361
  23. A.K. Chava., M. Chatterjee, S. Sundar and Chitra Mandal (2002) Development of an assay for quantification of linkage-specific O-acetylated sialoglycans on erythrocytes; its application in Indian visceral leishmnaiasis J. Immunol. Meth. 270, 1-10
  24. Sharma V, Chatterjee M, Sen G, Ch. Anil Kumar and Mandal Chitra (2000) Role of linkage specific 9-O-acetylated sialoglycoconjugates in activation of the alternate complement pathway on mammalian erythrocytes. Glycoconjugate J. 17:22
  25. Chatterjee M., Baneth G, Jaffe C L, Sharma V and Mandal Chitra. (1999) Diagnostic and prognostic potential of antibodies against O-acetylated sialic acids in canine visceral leishmaniasis" Veterinary Immunol. Immunopathol, 70, 55-65
  26. Chatterjee M., Jaffe C.L, Shyam S, Basu D, Sen S and Mandal Chitra. (1999) Diagnostic and Prognostic potential of a Competitive Enzyme linked Immunosorbent Assay for Leishmaniasis. Clinic. Diagnos. Lab. Immunol 6, 550-554
  27. Chatterjee M., Sharma V., *Mandal Chitra., Sundar S, and Sen S. (1998) Identification of antibodies directed against O-acetylated sialic acids in Visceral Leishmaniasis: its diagnostic and prognostic role. Glycoconjugate J. 15, 1141-1147.
  28. Sharma V, Chatterjee M, Mandal Chitra, Sen S, Basu D. (1998). Rapid diagnosis of visceral leishmaniasis using Achatinin-H, a 9-O-acetylated sialic acid binding lectin. Amer. J. Trop. Med. Hyg. 58, 551-554.
 
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