Scientists
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- Dr. Pradeep K. Dutta
- Dr. Basudeb Achari
- Dr. Anup Bhattacharjya
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Vision
The chemistry department aims at the study of chemical and biological problems through an integrated effort entailing discovery of new molecules from plants, development of synthetic strategies for complex molecules, studies on nanoscopic materials and reactions in organized media, and biophysical study of the interaction of biological macromolecules. Alongside, the department seeks to participate in the development of drugs and other important biomolecules through active collaboration with industrial and institutional partners.
Objectives
- To develop strategies for the synthesis of chiral cyclic ethers, amines and RNA analogs from carbohydrate derivatives.
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- To develop new synthetic methodologies, and synthesize heterocyclic compounds for screening biological activities.
- To establish methodologies for carbohydrate-derived structurally unique nucleosides.
- To develop and commercialize herbal medicines and other bioactive molecules.
- To synthesize oligosaccharides and neo-glycoproteins as vaccine candidates, and carry out structural studies on pathogenic bacterial lipopolysaccharides relevant to glycobiology and glycoscience.
- To design and synthesize medium ring heterocycles as potential anti-cancer, anti-hyperlipidemic and antimicrobial agents.
- To develop methodologies for the synthesis of anti-leishmanial and anti-encephalitis compounds based on quinolines.
- To design and synthesize novel chiral surfactants for exploring new reaction systems and reagents for carrying out selective organic reactions in organized media.
- To study nanoscopic materials such as stabilized nanoparticles and nanofibers.
- To isolate and characterize bioactive substances from medicinal plants.
- To understand the mode, mechanism, sequence specificity and energetics of binding of alkaloids and other natural products to polymorphic nucleic acid structures.
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Team Members - SRF/JRF/R A
Staff Members
| Name |
Designation |
| Mr. Kalyan K. Sarkar |
T.O |
| Dr. Sankar K Maitra |
T.O |
| Mr. Asit Kumar Das |
T.O |
| Mr. Sekhar Ghosh |
T.O |
| Mr. Subodh K. Roy |
T.O |
| Mr. Diptendu Bhattacharya |
T.O |
| Dr. Tapas Sarkar |
T.O |
| Mr. Sankar Prasad Datta |
Sr. Stenographer |
| Mr. Sandip Chowdhury |
TA |
| Mr S.K.Sarkhel |
Tech |
| Mr. Rajendra Mahato |
Helper |
| Mr. Nimai C. Pradhan |
Helper |
Others like project assistant/summer trainee etc
Important P&I in the last 5 years
- Sen, A.K, Sr., Das, A.K., Sarkar, K.K., Siddhanta, A.K., Takano, R., Kamei, K. and Hara, S. An agaroid-carrageenan hybrid type backbone structure for the antithrombotic sulfated polysaccharide from Grateloupia indica Boergensen (Halymeniales, Rhodophyta), Botanica Marina, 2002, 45, 331-338.
- Nandi, A. and Chattopadhyay, P., Synthesis of chiral trans-fused pyrano[3,2-c][2]benzoxocines from D-mannose by regioselective 8-endo-aryl radical cyclization, Tetrahedron Lett., 2002, 43, 5977.
- Sahu, N.P., Pal, C., Mandal, N.B., Banerjee, S., Raha,M., Kundu, A.P., Basu., A., Ghosh. M,. Roy, K. and Bandyopadhyay, S., Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide - a potential anti-leishmanial agent, Bioorg. Med. Chem., 2002, 10, 1687-1693.
- Maiti, S., Achari, B., Mukhopadhyay, R. and Banerjee, A. K., Heteroaryl radicals. Part 1. Synthesis of linear pyridine-fused ring systems by endo-selective 2-pyridyl radical cyclizations, J. Chem. Soc. Perkin Trans. I, 2002, 1766-1773.
- Ghorai, S., Bhattacharjya, A., Basak, A., Mitra, A. and Williamson, R. T., An expedient approach to internally functionalised chiral dendrimers: synthesis of a dendritic molecule incorporating furanoside skeleton., J. Org. Chem., 2003, 68, 617-620.
- Medda, S., Jaisankar, P., Manna, R. K., Pal, B., Giri, V.S. and Basu, M.K., Phospholipid microspheres: a novel delivery mode for targeting antileishmanial agent in experimental leishmaniasis, J. Drug. Targeting, 2003, 11, 123.
- Chatterjee, A., Maiti, D. K., Bhattacharya, P. K., Water exclusion reaction in aqueous media: nitrone formation and cycloadditionin a single pot, Org. Lett., 2003, 5, 3967-3969.
- Das, T., Sen, A. K., Kempf, T., Pramanik, S. R., Mandal C. and Mandal, C., Induction of glycosylation in human C-reactive protein under different pathological conditions, Biochem. J., 2003, 373, 345-355.
- Roychowdhury, A., Mandal, S., Goswami, A., Ghosh, M., Mandal, L., Chakraborty, A., Ganguly, G., Tripathi, S., Mukhopadhyay, S., Bandopadhyay, S. and Majumder, H.K., Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II : implications in antileishmanial therapy, Molecular Medicine, 2003, 9(1-2), 26 .
- Panda, N., Mandal, N. B., Banerjee, S., Sahu, N.P., Koike. K., Nikaido, T., Weber, M. and Luger, P., Polyhydroxy pregnanes from Dregea volubilis., Tetrahedron, 2003, 59, 8399-8403.
- Banerjee, M., Mukhopadhyay, R., Achari, B. and Bajerjee, A. K., First total synthesis of the 4a-methyltetrahydrofluorene diterpenoids (±)- dichroanal B and (±)- dichroanone, Org. Lett., 2003, 5, 3931-3933.
- Pal, B., Jaisankar, P., and Giri, V. S., Unusual formation of chiral b-carboline dimers under Bischler-Napieralski reaction conditions: an old reaction with a new direction, Tetrahedron Lett., 2004, 45, 6489-6492.
- Singha, K., Roy, A., Dutta, P. K., Tripathi, S., Sahabuddin, Sk., Achari, B. and Mandal, S. B., Intramolecular nitrone cycloaddition reaction on carbohydrate-based precursors: application in the synthesis of spironucleosides and spirobisnucleosides, J. Org. Chem., 2004, 69, 6507-6511.
- Bhattacharya, J., GhoshMoulick, R., Choudhuri, U., Chakrabarty, P., Bhattacharya, P.K., Lahiri, P., Chakraborti, B., Dasgupta, A.K., Unfolding of hemoglobin variants - insights from urea gradient gel electrophoresis photon correlation spectroscopy and zeta potential measurements, Analytica Chimica Acta, 2004, 522, 207-214.
- Dutta, R., Mandal, D., Panda, N., Mandal, N.B., Banerjee, S., Kumar, S., Weber, M., Luger, P. and Sahu, N.P., General methodology for synthesis of fused tricyclic oxazino-2-quinolones under phase-transfer catalyzed conditions, Tetrahedron Lett., 2004, 45, 9361-9364.
- Ghorai, S. and Bhattacharjya, A., Mercury (II) chloride mediated cyclization-rearrangement of O-propargylglycolaldehyde dithioacetals to 3-pyranone dithioketals: an expeditious access to 3-pyranones., Org. Lett., 2005, 7, 207-210.
- Pradhan, P. K., Dey, S., Giri, V. S. and Jaisankar, P., InCl3-HMTA as a methylene donor: one-pot synthesis of diindolylmethane (DIM) and its derivatives, Synthesis, 2005, 1779-1782 .
- Roy, A., Sahabuddin, Sk., Achari, B. and Mandal, S. B., Cyclization in situ of enose /ynose-nitrilimines: an expedient approach to the synthesis of chiral glycopyrazoles and pyrazolonucleosides, Tetrahedron, 2005, 61, 365-371.
- Chowdhury, P., Panja, S., Chatterjee, A., Bhattacharya, P. and Chakravorti, S., Prototropism in 2-acetyl benzimidazole and 2-benzimidazole., J. Photochem. Photobiol. A: Chem. 2005, 170, 131-141.
- Gupta, M., Achari, B. and Pal, B. C., Glucosides from Curculigo orchioides, Phytochemistry, 2005, 66, 659-663.
- Bera, R., Nayak, A., Sen, A. K., Chowdhury, B. P. and Bhadra, R., Isolation and characterization of the lipopolysaccharide from Acidiphilium strain GS18h/ATCC55963, a soil isolate of Indian copper mine, FEMS Microbiol. Lett., 2005, 246, 183-190.
- Bhattacharyya, K., Kar, T., Bocelli, G., Cantoni, A., Pramanick, S., Banerjee, S. and Mukhopadhyay, S., Redetermination of 14-deoxyandrographolide, Acta. Cryst., 2005, 61, 2743-2745.
- Neogi, A., Majhi, T. P., Ghoshal, N. and Chattopadhyay, P., Radical cyclization of exo-methylene furanose derivatives: an expedient approach to the synthesis of chiral tricyclic nucleosides and benzannulated oxepine derivatives, Tetrahedron, 2005, 61, 9368.
- Sengupta, S., Drew, M. G. B., Mukhopadhyay, R., Achari, B. and . Banerjee, A. K., Stereoselective syntheses of (±)-komaroviquinone and (±)-faveline methyl ether through intramolecular Heck reaction, J. Org. Chem., 2005, 70, 7694-7700.
- Nath, M., Mukhopadhyay, R. and Bhattacharjya, A., Divergent cycloaddition and ring-closing metathesis approaches to indolizidine and pyrrolo[1,2-a]azepine skeletons from a chiral precursor: an expeditious route to (-)-8-epi-swainsonine triacetate, Org. Lett., 2006, 8, 317-320.
- Sahabuddin, Sk., Drew, M. G. B., Roy, A., Achari, B. and Mandal, S. B., Sequential ring closing metathesis and nitrone cycloaddition on glucose derived substrates: a divergent approach to analogues of spiroannulated carbanucleosides and conformationally locked nucleosides, J. Org. Chem., 2006, 71, 5980-5992.
- Pramanick, S., Banerjee, S., Achari, B., Das, B., Sen, Sr., A. K., Mukhopadhyay, S., Neuman, A. and Prangé, T., Andropanolide and isoandrographolide, minor diterpenoids from Andrographis paniculata: structure and X-ray crystallographic analysis, J. Nat. Prod., 2006, 69, 403 - 405.
- Chatterjee, A. and Bhattacharya, P. K., Stereoselective synthesis of chiral oxepanes and pyrans through intramolecular nitrone cycloaddition in organized aqueous media, J. Org. Chem., 2006, 71, 345-348.
- Sinha, S, Pal, B.C., Jagadeesh, S, Banerjee, P. P, Bandyopadhaya, A and Bhattacharya, S, Mahanine inhibits growth and induces apoptosis in prostate cancer cells through the deactivation of Akt and activation of caspases, The Prostate, 2006, 66,1257 -1265.
- Joardar, A., Sen, A. K. and Das, S., Docosahexaenoic acid facilitates cell maturation and b-adrenergic transmission in astrocytes, J. Lipid Res., 2006, 47, 571-581.
- Neogi, A., Majhi, T. P., Mukhopadhyay, R. and Chattopadhyay, P., Palladium-mediated intramolecular aryl amination on furanose derivatives: an expedient approach to the synthesis of chiral benzoxazocine derivatives and tricyclic nucleosides, J Org Chem., 2006, 71, 3291.
- Giri, P., Hossain, M., and Suresh Kumar, G., RNA specific molecules: cytotoxic plant alkaloid palmatine binds strongly to poly(A), Bioorg. Med. Chem. Lett., 2006, 16, 2364-2368.
- Mandal, D., Panda, N., Kumar, S., Banerjee, S., Mondal, N.B., Sahu N. P., A triterpenoid saponin possessing antileishmanial activity from the leaves of Careya arborea, Phytochemistry, 2006, 67, 183-190.
- Banerjee, M., Mukhopadhyay, R., Achari, B. and Banerjee, A. K., General route to 4a-methylhydrofluorene diterpenoids: total syntheses of (±)-taiwaniaquinones D and H, (±)-taiwaniaquinol B, (±)-dichroanal B, and (±)-dichroanone, J. Org. Chem., 2006, 71, 2787-2796.
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