Cancer Biology & Inflammatory Disorder Division

Vision

This division has recently been created by bringing together six dedicated scientists and more than 50 research scholars with expertise in a broad range of cancer-related fields. Our long term goals are to focus on the comprehensive understanding of cancer at many levels ranging from the investigation of molecular and genetic basis of cancer, the elucidation of cellular processes altered during development of cancers, immune response and inflammation. The faculties conduct both basic and translational research on a range of topics that include lung, brain, oral, breast, pancreatic and cervical cancers and leukemias etc. Our current focus is on identification of pure herbal and/or synthetic compounds/herbal extracts having in-vitro anti-proliferative activities against different cancer cell lines, understanding alterations and cross-talks among signalling pathways in cancers. Emphasis is also given on characterization of novel targets, identification of target-specific leads and biologics using systems biology approaches. Optimization of lead molecules by development of in-silico library of compounds through pharmacophore modeling and structure-based drug design, drug delivery, in vivo efficacy, pharmacokinetics and in-vivo toxicity/safety pharmacology are a few current activities of the division. Research on cancer stem cells is ongoing.  Development of animal models of tumor is our major future goal to study signaling crosstalk in vivo. The collaboration with Medicinal Chemistry, Bioinformatics, in-silico modeling groups and interaction with clinicians make this division a rapidly growing unit with a unique goal to deliver low cost affordable healthcare by providing novel diagnostics and therapeutics in cancers.

Scientists

Technical Officers

Research Summary

Dr.Chitra Mandal

  • Role of sialic acid modulator enzymes in leukemia and pancreatic cancer.
  • Glycoproteomics of leukemia-associated sialoglycans and their functional role
  • Development of the high efficacy anti-cancer agent from the natural sources on the basis of the knowledge of existing structure.
  • Checking the efficacy of herbal compounds combination with existing toxic anti-cancer drugs.
  • Synthetically modification of herbal compound for identification of main functional group(s) and interaction with DNA through biophysical and in silico approaches.
  • Cellular signal networking modulation of two identified potential herbal compounds for target protein identification through in vitro, proteomics and in silico approaches.
  • G1/S and G2/M regulation and role of novel herbal compound in glioma and pancreatic cancer.

Dr.Santu Bandyopadhyay

  • Evaluation of differential sensitivity of cancer cells vs. normal cells to ROS-inducing natural products with mechanisms of action.
  • Redox regulation of cancer cell apoptosis.
  • Reversal of drug-resistance by redox manipulation

Dr.Susanta Roychowdhury

  • Deciphering the mechanism of chromosomal instability in human cancer.
  • Deciphering the mechanism of chemo-resistance in human cancer.
  • Identification of susceptibility alleles for the development of oral cancer.
  • Understanding of cause and consequences of mitotic abnormality in human cancer.

Dr. Padma Das

  • Isolate, identify, characterize and evaluate the biological effects of the compounds extracted from mycelia and/or fruit bodies of edible mushrooms and Sesbania grandiflora flower extract etc.
  • Understanding the mechanism of Andrographolide analogue mediated apoptosis in human leukemic cells.

Dr. Mrinal K. Ghosh

  • Understand the cross-regulation of Wnt/β-catenin and EGFR signalling.
  • Role and regulation of ubiquitin ligases & deubiquitinases in post-translational modifications of crucial proteins like c-Myc, PTEN & pRb.
  • Involvement (mode & mechanism) of DEAD Box RNA Helicase (p68).
  • Development of in vivo Animal Models of Tumor and Study of Signaling Crosstalk.
  • Exploration of Aberrations in Cancer Stem Cell Signaling.
  • Development of More Effective Prognostics and Therapeutics Against Brain Cancer

Dr. Malini Sen

  • Evaluating the role of Wnt Signaling in Immune response and Inflammation.
  • Evaluating the role of WISP3 (Wnt induced secreted protein 3) in the regulation of cellular hypertrophy and oxidative stress.
  • Investigating means for inhibition of inflammation and oxidative stress upon detailed analysis of appropriate signal transduction pathways.

Dr. Amitava Sengupta

  • Cell-autonomous mechanisms of hematopoietic stem cell transformation.
  • Epigenetic regulation of leukemia stem cell heterogeneity.
  • Microenvironment regulation in hematopoiesis

Dr. Dipyaman Ganguly

  • Innate immune regulation and molecular mechanisms of dendritic cell function
  • Deciphering the role and modulation of dendritic cells in tumor microenvironment and cancer immunotherapy
  • Clinical/Translational Immunology: innate immune contribution in metabolic disorders; autologous DC vaccination in solid tumor
  • Neuro-immune interface: physico-biochemical crosstalk between the central nervous system and the innate immune system

          Dr. (Mrs.)  Krishna Das Saha

  • Anti-inflammatory activity with compounds of natural sources, microbial origins, and nano formulated compounds
  • Anticancer activity of compounds natural and synthetic compounds and of metal complexes
  • Immunostimulatory and antimicrobial activity of some compounds of natural origin

 


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