Under the BTIS net programme of DBT, a Bioinformatics Center titled "Distributed Information Sub-Centre (DISC)" has been established in October, 2002 in IICB.

Team Members :  Dr. Chitra Dutta             –    Coordinator Mr. Sanjib Chatterjee  –    Project Assistant Mr. Sandip Paul          –     Project Assistant Mr. Sumit K. Bag         –    Project Assistant

Objectives To build up information resource on biotechnology/genomics/proteomics and to develop relevant information handling tools and techniques. To develop and conduct original research programmes on in silico biology (especially in the areas of genome analysis and metagenomics). To provide a national bio-information network designed to bridge the interdisciplinary gaps in biotechnology information. To facilitate and enhance application of bioinformatics in life science research and to provide bioinformatics related technical support services to the national community of users. To organize long-term/short-term training programmes in diverse application of bioinformatics and computational biology. Computing facilities Hardware SGI Octane Workstations High End Server (Itenium II Hp Integrity Server 4640), Linux OS Mail Server (Xeon server) Ftp Server (Xeon server) P4 PCs Laser Printers DeskJet Printers High speed Network Printer (200 Mb) with Copier and Scanner function High Resolution Scanners Software In-House Software Development Activity Novel algorithms and programs are being developed by the members of the centre for macromolecular sequence analysis.  Among the in-house software tools currently available at the Centre are : (A) GCA & ClusterViz - A pair of programs, developed in C++ and Perl, for clustering of protein/gene sequences based on Markov-Chain Monte Carlo simulation and integrated visualization of the clusters with hyperlinks to their taxonomic distributions and functional annotations (B)  SPAST (Substitution Pattern Analysis Software Tool) - An integrated software tool for quantitative analysis of (i) Nucleotide Substitution (synonymous/ non-synonymous/ non-coding) Patterns (ii) Amino Acid Substitution Patterns and (iii) changes in propensities for secondary structure formation in orthologous or paralogous genes/gene-products (C) PROCGR - A PC-based software tool, written in GWBASIC, developed for generation of Chaos Game Representation (CGR) patterns of different families of proteins. Commercially acquired software packages : Insight II Platform in Silicon Graphics Octane (Version 2000.1)              Modules:                          Homology Modeling                          Delphi                         Biopolymer                         DOCKING GCG Wisconsin Package (Version 10.3) & SeqWeb (Version 2.1) (Sequence Analysis Package) DNA Star Laser gene (Genome and Protein Sequence Analysis) DS Gene (Version 1.5) - (A suite of protein modeling & simulation tools) Statistica (Version 6)  (Statistical Analysis Package) Corel Draw Visual Studio .NET End Note (Version 8.0.2 ) Sigma plot (Version 9.0) Adobe Creative Suite

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